Tetsuo Aida
Daiichi Sankyo
AntigenMolecular biologyAntibodyChemistryImmunologyAllergyPrimary and secondary antibodiesT cellBenzylpenicillinHumoral immunityKeyhole limpet hemocyaninGuinea pigPeptideTrastuzumabImmunopathologyToxicityStrain (chemistry)MedicineBiologyImmune systemPharmacology
14Publications
6H-index
239Citations
Publications 13
Newest
#1Kazuyoshi Kumagai (Daiichi Sankyo)H-Index: 7
#2Tetsuo Aida (Daiichi Sankyo)H-Index: 6
Last. Kazuhiko Mori (Daiichi Sankyo)H-Index: 9
view all 6 authors...
Trastuzumab deruxtecan (T-DXd: DS-8201a) is an anti-human epidermal growth factor receptor 2 (HER2) Ab-drug conjugated with deruxtecan (DXd), a derivative of exatecan. The objective of this study was to characterize T-DXd-induced lung toxicity in cynomolgus monkeys. Trastuzumab deruxtecan was injected i.v. into monkeys once every 3 weeks for 6 weeks (10, 30, and 78.8 mg/kg) or for 3 months (3, 10, and 30 mg/kg). To evaluate the involvement of DXd alone in T-DXd-induced toxicity, DXd monohydrate ...
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#1Tomohiro Shirayanagi (Chiba University)H-Index: 1
#2Shigeki Aoki (Chiba University)H-Index: 7
Last. Kousei Ito (Chiba University)H-Index: 29
view all 9 authors...
The interaction of human leukocyte antigen (HLA) with specific drugs is associated with delayed-type hypersensitivity reactions, which cause severe cutaneous toxicity. Such interactions induce structural alterations in HLA complexes via several different mechanisms such as the hapten theory, p-i concept, and altered peptide repertoire model, leading to the activation of cytotoxic T cells. To date, comprehensive detection of such structural alterations in preclinical studies has been difficult. H...
1 CitationsSource
#1Eri Hamamura-Yasuno (Daiichi Sankyo)H-Index: 1
#2Tetsuo Aida (Daiichi Sankyo)H-Index: 6
Last. Kazuhiko Mori (Daiichi Sankyo)H-Index: 9
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Injection site reaction (ISR) is a common side-effect associated with the use of peptide or protein pharmaceuticals. These types of pharmaceuticals-induced activation of antigen-presenting cells is assumed to be a key step in the pathogenesis of immune-mediated ISR. The present study was designed to evaluate the immunostimulatory properties of peptide or protein pharmaceuticals using human monocytic THP-1 cells. Here, THP-1 cells, with or without phorbol-12-myristate-13-acetate (PMA) pretreatmen...
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#1Daisuke Okajima (Daiichi Sankyo)H-Index: 4
#2Satoru Yasuda (Daiichi Sankyo)H-Index: 3
Last. Toshinori Agatsuma (Daiichi Sankyo)H-Index: 12
view all 16 authors...
e24206Background: DS-1062a is a trophoblast cell surface protein 2 (TROP2)-targeting antibody-drug conjugate (ADC) comprised of a humanized anti-TROP2 monoclonal antibody, enzymatically cleavable p...
5 CitationsSource
#1Lydia M. Kwast (UU: Utrecht University)H-Index: 5
#2Tetsuo Aida (Daiichi Sankyo)H-Index: 6
Last. Raymond Pieters (UU: Utrecht University)H-Index: 36
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Immune-mediated drug hypersensitivity reactions (IDHR) may result from immuno-sensitization to a drug-induced neo-antigen. They rarely occur in patients and are usually not predicted preclinically using standard toxicity studies. To assess the potential of a drug to induce T-cell sensitization, trinitrophenyl (TNP)-Ficoll was used here as a bystander antigen in animal experiments. TNP-Ficoll will only elicit TNP-specific IgG antibodies in the presence of non-cognate T-cell help. Therefore, the p...
1 CitationsSource
#1Yusuke Ogitani (Daiichi Sankyo)H-Index: 8
#2Tetsuo Aida (Daiichi Sankyo)H-Index: 6
Last. Toshinori Agatsuma (Daiichi Sankyo)H-Index: 12
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Purpose: An anti-HER2 antibody–drug conjugate with a novel topoisomerase I inhibitor, DS-8201a, was generated as a new antitumor drug candidate, and its preclinical pharmacologic profile was assessed. Experimental Design:In vitro and in vivo pharmacologic activities of DS-8201a were evaluated and compared with T-DM1 in several HER2-positive cell lines and patient-derived xenograft (PDX) models. The mechanism of action for the efficacy was also evaluated. Pharmacokinetics in cynomolgus monkeys an...
175 CitationsSource
#1Ryota Kawai (Daiichi Sankyo)H-Index: 4
#2Tetsuo Aida (Daiichi Sankyo)H-Index: 6
Last. Teruo Kawada (Kyoto University)H-Index: 65
view all 8 authors...
T-cell dependent antibody response (TDAR) incorporating both primary and secondary responses to keyhole limpet hemocyanin (KLH) in canine models have not yet been fully understood. To develop a practical dog TDAR model, we characterized primary and secondary antibody responses by intravenous or intramuscular immunization of KLH twice at intervals of 8 days during a 28-day course of study. Primary immunization with KLH by both routes induced a maximum IgM response on 6 to 8 days after the treatme...
4 CitationsSource
#1Ryota KawaiH-Index: 4
#2Shiho ItoH-Index: 1
Last. Teruo Kawada (Kyoto University)H-Index: 65
view all 9 authors...
To develop a rat T-cell-dependent antibody response (TDAR) model evaluating both primary and secondary antibody responses, keyhole limpet hemocyanin (KLH) was used to immunize rats twice during a 14-day course of study, a pattern closely linked to that of a short-term general toxicity study. Female rats of four representative strains (e.g., Sprague-Dawley, Wistar, Fischer, and Lewis) were immunized twice with intravenous administrations of KLH (300 µg/rat) on Days 5 and 9 during a 14-day treatme...
17 CitationsSource
#1Tetsuo AidaH-Index: 6
#2Ryota KawaiH-Index: 4
Last. Tadashi FurukawaH-Index: 8
view all 4 authors...
#1Tetsuo AidaH-Index: 6
#2Tsutomu KimuraH-Index: 2
Last. Kenkichi ShinkaiH-Index: 4
view all 4 authors...
In the present study, the correlation between mouse PLNA and those obtained from GP-PCA and from GP-ASA reactions fro sodium 2, 4, 6-trinitrobenzenesulfonate dihydrate (TNBS), penicillin G and cephalothin was investigated. Next, variou drugs were tested using the mouse PLNA to study whether PLN reactivity could be related to the potential of the compounds to induce allergic and autoimmune disorders in humans. The parameter of the PLNA was determined by the PLN cellularity index in BALB/c and A/J...
13 CitationsSource