Antonietta Bartoli
National Research Council
Imaging phantomWarburg effectMatrix metalloproteinasePhysicsBiophysicsMultiple drug resistanceBiomedical engineeringTP53-inducible glycolysis and apoptosis regulatorTransporterMolecular biologyEndogenyImage registrationReceptorFiducial markerChemistryMaterials scienceMedical physicsEffluxGlycolysisImage resolutionIn vivoEx vivoPositron emission tomographyLactic acidMatrix metalloproteinase inhibitorTumor microenvironmentWestern blotAdenosineFluorodeoxyglucoseTyrosine phosphorylationBiodistributionGlucose uptakeCarboxylateExperimental autoimmune encephalomyelitisAcidosisTariquidarP-glycoproteinScannerInterstitial fluidExtracellularMitochondrionActive inflammationPreclinical imagingPet imagingDisease severityHigh resolutionCo registrationProgrammed cell deathDynamic contrast-enhanced MRICancer researchImage qualityBiochemistryAnaerobic glycolysisSignal transductionMolecular medicineAdenosine receptorCell cultureBiologyCell biologyPharmacologyReproducibility
Publications 8
#1Dario Livio Longo (National Research Council)H-Index: 28
#2Antonietta Bartoli (UNITO: University of Turin)H-Index: 7
Last. Silvio Aime (UNITO: University of Turin)H-Index: 91
view all 7 authors...
The vast majority of cancers exhibit increased glucose uptake and glycolysis regardless of oxygen availability. This metabolic shift leads to an enhanced production of lactic acid that decreases extracellular pH (pHe), a hallmark of the tumour microenvironment. In this way, dysregulated tumour pHe and up-regulated glucose metabolism are linked tightly and their relative assessment may be useful to gain understanding of the underlying biology. Here we investigated non-invasively the in vivo corre...
99 CitationsSource
#1Debora PetroniH-Index: 7
#2Antonietta Bartoli (UNITO: University of Turin)H-Index: 7
Last. Luca MenichettiH-Index: 18
view all 12 authors...
Purpose The plasma membrane P-glycoprotein (Pgp) is an efflux transporter involved in multidrug resistance and in the onset of neurodegenerative disease. Its function and most mechanisms of action are still under investigation. We developed a C-11-labeled 2-arylethylphenylamine-([11C]AEPH) derivative for positron emission tomography (PET), as a novel probe to better understand the activity and the function of Pgp in vivo.
#1Debora PetroniH-Index: 7
#2Chiara Giacomelli (UniPi: University of Pisa)H-Index: 22
Last. Luca MenichettiH-Index: 18
view all 14 authors...
Abstract Introduction A 2B adenosine receptors (ARs) are commonly defined as “danger” sensors because they are triggered during cell injury when the endogenous molecule, adenosine, increases rapidly. These receptors, together with the other receptor subtypes (A 1 , A 2A and A 3 ), exert a wide variety of immunomodulating and (cyto)protective effects, thus representing a pivotal therapeutic target for different pathologies including diabetes, tumors, cardiovascular diseases, pulmonary fibrosis an...
9 CitationsSource
#1Antonietta Bartoli (UNITO: University of Turin)H-Index: 7
#2Giovanna Esposito (UNITO: University of Turin)H-Index: 10
Last. Enzo Terreno (UNITO: University of Turin)H-Index: 58
view all 5 authors...
To obtain an accurate co-registration with stand-alone PET and MRI scanners, we developed a compatible bed system for mice and rats that enables both images to be acquired without repositioning the animals. MRI acquisitions were performed on a preclinical 7T scanner (Pharmascan, Bruker), whereas PET scans were acquired on a YAP-(S)PET (ISE s.r.l.). The bed performance was tested both on a phantom (NEMA Image Quality phantom) and in vivo (healthy rats and mice brain). Fiducial markers filled up w...
2 CitationsSource
#1F Casalini (University of Eastern Piedmont)H-Index: 1
#2Lorenza FugazzaH-Index: 3
Last. Alessandro MaiocchiH-Index: 14
view all 20 authors...
New fluorinated, arylsulfone-based matrix metalloproteinase (MMP) inhibitors containing carboxylate as the zinc binding group were synthesized as radiotracers for positron emission tomography. Inhibitors were characterized by Ki for MMP-2 in the nanomolar range and by a fair selectivity for MMP-2/9/12/13 over MMP-1/3/14. Two of these compounds were obtained in the 18F-radiolabeled form, with radiochemical purity and yield suitable for preliminary studies in mice xenografted with a human U-87 MG ...
13 CitationsSource
#1Giovanna Esposito (UNITO: University of Turin)H-Index: 10
#2Luca D'Angeli (UNITO: University of Turin)H-Index: 3
Last. Enzo Terreno (UNITO: University of Turin)H-Index: 58
view all 5 authors...
Abstract Positron Emission Tomography (PET) with 18 F-FDG is a promising tool for the detection and evaluation of active inflammation in animal models of neuroinflammation. MRI is a complementary imaging technique with high resolution and contrast suitable to obtain the anatomical data required to analyze PET data. To combine PET and MRI modalities, we developed a support bed system compatible for both scanners that allowed to perform imaging exams without animal repositioning. With this approac...
1 CitationsSource
#1Giuseppe DigilioH-Index: 18
#2Francesca CasaliniH-Index: 10
Last. Antonietta BartoliH-Index: 7
view all 14 authors...
#1Marco Demaria (UNITO: University of Turin)H-Index: 34
#2Carlotta Giorgi (University of Ferrara)H-Index: 61
Last. Valeria Poli (UNITO: University of Turin)H-Index: 77
view all 14 authors...
The pro-oncogenic transcription factor STAT3 is constitutively activated in a wide variety of tumours that often become addicted to its activity, but no unifying view of a core function determining this widespread STAT3-dependence has yet emerged. We show here that constitutively active STAT3 acts as a master regulator of cell metabolism, inducing aerobic glycolysis and down-regulating mitochondrial activity both in primary fibroblasts and in STAT3-dependent tumour cell lines. As a result, cells...
183 CitationsSource