Chen Liu
Sun Yat-sen University
Cardiac function curveInternal medicineEndocrinologyCardiologyMuscle hypertrophyGene knockdownChemistryAutophagyHazard ratioHeart failure with preserved ejection fractionHeart failurePressure overloadAtrial fibrillationPopulationIn patientConfidence intervalProportional hazards modelMedicineEjection fractionBiologyCell biology
57Publications
11H-index
343Citations
Publications 58
Newest
#1Peisen Huang (SYSU: Sun Yat-sen University)H-Index: 1
#2Yuan Yu (Academy of Medical Sciences, United Kingdom)H-Index: 1
Last. Chen LiuH-Index: 11
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AIMS To determine the associations of long-term SBP (LT-SBP) levels with clinical outcomes and health-related quality of life in heart failure with preserved ejection fraction (HFpEF). METHODS AND RESULTS We analyzed participants from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) study with available different SBP measurements from different follow-ups (n = 3310). LT-SBP was the mean SBP value from 4-week measurement to the last one. The outcom...
1 CitationsSource
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#1Chen Liu (SYSU: Sun Yat-sen University)H-Index: 11
#1Xin He (SYSU: Sun Yat-sen University)H-Index: 2
Last. Bin Dong (SYSU: Sun Yat-sen University)H-Index: 9
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AIMS Heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) had distinct haemodynamic characteristics in the setting of acute heart failure. The aim of our study is to evaluate the differential response to aggressive diuresis in HFrEF and HFpEF. METHODS AND RESULTS Patients in the Diuretic Optimization Strategies Evaluation trial with left ventricular ejection fraction measurement were included (n = 300) and classified into HFrEF [left ven...
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#1Weihao Liang (SYSU: Sun Yat-sen University)H-Index: 3
#2Xin He (SYSU: Sun Yat-sen University)H-Index: 4
Last. Chen Liu (SYSU: Sun Yat-sen University)H-Index: 11
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Background: Liver dysfunction is prevalent in patients with heart failure (HF), but the prognostic significance of liver function tests (LFTs) remains controversial. Heart failure with preserved ejection fraction (HFpEF) had been introduced for some time, but no previous study had focused on LFTs in HFpEF. Thus, we aim to evaluate the prognostic significance of LFTs in well-defined HFpEF patients. Methods and Results: We conveyed a post hoc analysis of the TOPCAT trial. The primary outcome was t...
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#1Wengen Zhu (SYSU: Sun Yat-sen University)H-Index: 14
#2Yuzhong WuH-Index: 3
Last. Chen LiuH-Index: 11
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OBJECTIVE In patients with heart failure with preserved ejection fraction (HFpEF), whether living alone could contribute to a poor prognosis remains unknown. We sought to investigate the association of living alone with clinical outcomes in patients with HFpEF. METHODS Symptomatic patients with HFpEF with a follow-up of 3.3 years (data collected from August 2006 to June 2013) in the TOPCAT trial were classified as patients living alone and those living with others. The primary outcome was define...
1 CitationsSource
#1Zexuan WuH-Index: 2
#2Yuanyuan ZhouH-Index: 2
Last. Yuzhong WuH-Index: 3
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#1Fang-Fei Wei (SYSU: Sun Yat-sen University)H-Index: 13
#2Yuanyuan Zhou (SYSU: Sun Yat-sen University)H-Index: 2
Last. Chen Liu (SYSU: Sun Yat-sen University)H-Index: 11
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Whether visit-to-visit blood pressure variability (BPV) is associated with adverse outcomes in patients with heart failure (HF) with preserved ejection fraction is unclear. We assessed these associ...
1 CitationsSource
#1Youchen Yan (SYSU: Sun Yat-sen University)H-Index: 2
#2Rong Tang (SYSU: Sun Yat-sen University)H-Index: 1
Last. Zhan-Peng Huang (SYSU: Sun Yat-sen University)H-Index: 18
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Abstract Hypertrophic growth of cardiomyocytes is one of the major compensatory responses in the heart after physiological or pathological stimulation. Protein synthesis enhancement, which is mediated by the translation of messenger RNAs, is one of the main features of cardiomyocyte hypertrophy. Although the transcriptome shift caused by cardiac hypertrophy induced by different stimuli has been extensively investigated, translatome dynamics in this cellular process has been less studied. Here, w...
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#1Jian Liu (Southern Medical University)H-Index: 1
#2Zejun Guo (SCNU: South China Normal University)H-Index: 1
Last. Chen Liu (SYSU: Sun Yat-sen University)H-Index: 11
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Objective Limited data have been published concerning about depression in heart failure with preserved ejection fraction (HFpEF). Besides, among HFpEF patients with depression, the efficacy of antidepressants is poorly defined. Therefore, our current study was aimed to examine the relationship between major depression and clinical outcomes in HFpEF patients and further address the effects of antidepressants on prognosis in patients with major depression and HFpEF. Methods A total of 1431 patient...
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#1Weihao Liang (SYSU: Sun Yat-sen University)H-Index: 3
#2Yuzhong Wu (SYSU: Sun Yat-sen University)H-Index: 3
Last. Chen Liu (SYSU: Sun Yat-sen University)H-Index: 11
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Background The C2HEST score has been validated for predicting AF in the general population or post-stroke patients. We aimed to assess whether this risk score could predict incident AF and other clinical outcomes in heart failure with preserved ejection fraction (HFpEF) patients. Methods A total of 2202 HFpEF patients without baseline AF in the TOPCAT trial were stratified by baseline C2HEST score. Cox proportional hazard model and competing risk regression model was used to explore the relation...
2 CitationsSource