Senthilnathan Palaniyandi
University of Kentucky
HaematopoiesisInternal medicineChemokineMicrobiomeTumor necrosis factor alphaApoptosisImmunologyT cellHematopoietic stem cell transplantationCytokineDiseaseGraft-versus-host diseaseBone marrowFibrosisPathogenesisTransplantationLung injuryHematopoietic cellCancer researchMedicineBiologyImmune system
31Publications
9H-index
452Citations
Publications 31
Newest
#1Reena Kumari (UK: University of Kentucky)H-Index: 4
#2Senthilnathan Palaniyandi (UK: University of Kentucky)H-Index: 9
Last. Gerhard C. Hildebrandt (UK: University of Kentucky)H-Index: 23
view all 3 authors...
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#1Reena Kumari (UK: University of Kentucky)H-Index: 4
#2Senthilnathan Palaniyandi (UK: University of Kentucky)H-Index: 9
Last. Gerhard C. Hildebrandt (UK: University of Kentucky)H-Index: 23
view all 4 authors...
Source
#1Senthilnathan Palaniyandi (UK: University of Kentucky)H-Index: 9
#2Reena Kumari (UK: University of Kentucky)H-Index: 4
Last. Gerhard C. Hildebrandt (UK: University of Kentucky)H-Index: 23
view all 8 authors...
BACKGROUND Prolyl hydroxylase inhibitors (PHI) promote stabilization of hypoxia-inducible factor-1 alpha (HIF-1α) and affect signaling cascades of inflammation and cell death. Their beneficial use in experimental models of ulcerative colitis and lung allograft rejection led us to test the effect of the PHI dimethyl oxalyl glycine (DMOG) in the pathophysiology of graft versus host disease (GVHD). METHODS Acute GVHD was induced in lethally irradiated BALB/c mice. DMOG was administered intraperiton...
Source
#1Reena KumariH-Index: 4
Last. Gerhard C. Hildebrandt (UK: University of Kentucky)H-Index: 23
view all 3 authors...
Allogeneic hematopoietic stem cell transplantation (HSCT) is the solitary therapeutic therapy for many types of hematological cancers. The benefits of this procedure are challenged by graft vs. host disease (GVHD), causing significant morbidity and mortality. Recent advances in the metabolomics field have revolutionized our understanding of complex human diseases, clinical diagnostics and allow to trace the de novo biosynthesis of metabolites. There is growing evidence for metabolomics playing a...
Source
#1Reena Kumari (UK: University of Kentucky)H-Index: 4
#2Senthilnathan Palaniyandi (UK: University of Kentucky)H-Index: 9
Last. Gerhard C. Hildebrandt (UK: University of Kentucky)H-Index: 23
view all 11 authors...
BACKGROUND: Gastrointestinal acute graft-versus-host disease (GVHD) occurring after allogeneic hematopoietic cell transplant is an allo-reactive T cell and inflammatory cytokine driven organ injury with epithelial apoptosis as 1 of its hallmark findings and is associated with significant mortality. Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8 or TIPE) acts as a negative mediator of apoptosis via inhibition of caspase-3 activation, promotes cell proliferation and Tipe deficiency i...
Source
#1Senthilnathan Palaniyandi (UK: University of Kentucky)H-Index: 9
#2Reena Kumari (UK: University of Kentucky)H-Index: 4
Last. Gerhard C. Hildebrandt (UK: University of Kentucky)H-Index: 23
view all 7 authors...
Introduction Graft versus host disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). The pathophysiology of acute GVHD involves donor T cell- and inflammatory cytokine-mediated injury to the patient's tissues and causes significant morbidity and mortality. Defibrotide is a mixture of single stranded nucleotides that has a number of pharmacological effects that contribute to its endothelial protective properties. We hypothesized that preventive ...
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#1Senthilnathan Palaniyandi (UK: University of Kentucky)H-Index: 9
#2Reena Kumari (UK: University of Kentucky)H-Index: 4
Last. Gerhard C. Hildebrandt (UK: University of Kentucky)H-Index: 23
view all 8 authors...
Source
#1Ethan Strattan (UK: University of Kentucky)H-Index: 4
#2Senthilnathan Palaniyandi (UK: University of Kentucky)H-Index: 9
Last. Gerhard C. Hildebrandt (UK: University of Kentucky)H-Index: 23
view all 10 authors...
Allogeneic hematopoietic stem cell transplant (allo-HSCT) is often used to treat acute leukemia or defects of hematopoiesis. Its widespread use is hampered by graft-versus-host disease (GVHD), which has high morbidity and mortality in both acute and chronic subtypes. Chronic GVHD (cGVHD) occurs most frequently in skin and often is characterized by pathogenic fibrosis. Mast cells (MCs) are known to be involved in the pathogenesis of other fibrotic diseases. In a murine model of cGVHD after allo-H...
Source
#1Ethan Strattan (UK: University of Kentucky)H-Index: 4
#2Senthilnathan Palaniyandi (UK: University of Kentucky)H-Index: 9
Last. Gerhard C. Hildebrandt (UK: University of Kentucky)H-Index: 23
view all 10 authors...
Allogeneic hematopoietic stem cell transplant (allo-HSCT) is often used to treat acute leukemia or defects of hematopoiesis. Its widespread use is hampered by graft-versus-host disease (GVHD), which has high morbidity and mortality in both acute and chronic subtypes. Chronic GVHD (cGVHD) occurs most frequently in skin and often is characterized by pathogenic fibrosis. Mast cells (MCs) are known to be involved in the pathogenesis of other fibrotic diseases. In a murine model of cGVHD after allo-H...
Source
#1Ethan StrattanH-Index: 4
Last. Gerhard C. Hildebrandt (UK: University of Kentucky)H-Index: 23
view all 8 authors...
7050Background: Allogeneic hematopoietic stem cell transplantation (allo-HCT) is a potentially curative treatment for patients with malignant neoplasms or inborn defects of hematopoiesis. Benefits ...
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