Mohamad Bagher Tavakoli
Isfahan University of Medical Sciences
DosimeterCytotoxicityIrradiationCancerNuclear chemistryMagnetic resonance imagingRadiationNanoparticlePhotonLinear particle acceleratorChemistryMaterials scienceMonte Carlo methodRadiosensitivityBone mineralHeLaHepatocellular carcinomaIron oxide nanoparticlesHyperthermiaTrypan blueMTT assayNuclear medicineNuclear magnetic resonanceRadiation therapyViability assayGadoliniumMedicineDosimetryCell cultureCancer cell
25Publications
4H-index
46Citations
Publications 20
Newest
#1Fatemeh Maghsoudinia (IUMS: Isfahan University of Medical Sciences)H-Index: 1
#2Mohamad Bagher Tavakoli (IUMS: Isfahan University of Medical Sciences)H-Index: 4
Last. Masoud A. Mehrgardi (UI: University of Isfahan)H-Index: 21
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Abstract Dual-modal molecular imaging by combining two imaging techniques can provide complementary information for early cancer diagnosis and therapeutic monitoring. In the present manuscript, folic acid (FA)-functionalized gadolinium-loaded nanodroplets (NDs) are introduced as dual-modal ultrasound (US)/magnetic resonance (MR) imaging contrast agents. These phase-change contrast agents (PCCAs) with alginate (Alg) stabilizing shell and a liquid perfluorohexane (PFH) core were successfully synth...
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#1Fatemeh Maghsoudinia (IUMS: Isfahan University of Medical Sciences)H-Index: 1
#2Mohamad Bagher Tavakoli (IUMS: Isfahan University of Medical Sciences)H-Index: 4
Last. Masoud A. Mehrgardi (UI: University of Isfahan)H-Index: 21
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Abstract In this study, single- and dual-targeted gadolinium-carbon dots (Gd-CDs) with Bevacizumab (BEV) and/or folic acid (FA) were developed as dual-modal fluorescence and magnetic resonance (FL/MR) imaging nanoprobes. Gd-CDs were prepared by a single-pot hydrothermal route using citric acid, ethylenediamine, and Gd-DO3A-butrol (Gadovist) as the starting materials. Mouse hepatocellular carcinoma (Hepa1-6) cell line was selected as cancer cells, while mouse fibroblast (L929) was used as a norma...
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#1Roghayeh Kamran Samani (IUMS: Isfahan University of Medical Sciences)H-Index: 2
#2Mohamad Bagher Tavakoli (IUMS: Isfahan University of Medical Sciences)H-Index: 4
Last. Masoud A. Mehrgardi (UI: University of Isfahan)H-Index: 21
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Abstract In the present study, the effect of functionalized gold nanoclusters (AuNCs) with trastuzumab (Herceptin®) and/or folic acid (FA) as a single and dual-targeted radiosensitizers for the enhancement of megavoltage radiation therapy efficacy was investigated. SK-BR3 breast cancer cells as human epidermal growth factor 2 (HER2) and folate overexpressing cell line and the murine fibroblast (L929) as a control cell line were selected. The cellular uptake was followed using inductively coupled...
3 CitationsSource
#1Mojtaba Karbalaee (IUMS: Isfahan University of Medical Sciences)H-Index: 1
#2Daryoush Shahbazi-Gahrouei (IUMS: Isfahan University of Medical Sciences)H-Index: 16
Last. M B Tavakoli (IUMS: Isfahan University of Medical Sciences)
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Background: An accurate and fast radiation dose calculations method is the main part of treatment planning for successful radiation therapy. Objective: This work aimed to create a novel GPU-based fast Monte Carlo Photon Dose Code (MCPDC) as a fast and accurate tool in dose calculation for radiotherapy treatment planning. Materials and Methods: In this analytical study, MCDPC was written to implement photon MC simulation for energies 0.01 to 20 MeV and run on an NVIDIA GTX970. The code was valida...
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#1P. Shoa (IUMS: Isfahan University of Medical Sciences)
#2Iraj Abedi (IUMS: Isfahan University of Medical Sciences)H-Index: 2
Last. Keyvan Jabbari (IUMS: Isfahan University of Medical Sciences)H-Index: 6
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#2Mohamad Bagher Tavakoli (IUMS: Isfahan University of Medical Sciences)H-Index: 4
Last. M B Tavakoli (IUMS: Isfahan University of Medical Sciences)H-Index: 2
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Background: aimed to compare the apparent diffusion coefficient (ADC) of two different cerebellar pediatric tumors, including ependymoma and medulloblastoma which have shown similar clinical images in conventional magnetic resonance imaging (MRI) methods.Material and Methods: Thirty six pediatric patients who were suspected to have the mentioned tumors according to their CT image findings were included in this study. The patients were subjected to conventional MRI protocols followed by diffusion...
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#1Hamid Fakhimikabir (IUMS: Isfahan University of Medical Sciences)H-Index: 2
#2Mohamad Bagher Tavakoli (IUMS: Isfahan University of Medical Sciences)H-Index: 4
Last. Soheila Rahgozar (UI: University of Isfahan)H-Index: 16
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Abstract The therapeutic effect of polyglycerol coated iron oxide nanoparticles (PG-SPIONs, non-targeted nanoparticles) and folic acid-conjugated polyglycerol coated iron oxide nanoparticles (FA-PG-SPIONs, targeted nanoparticles) in combination with hyperthermia on viability of HeLa cells was investigated. It was observed that coated and uncoated SPIONs have spherical shapes with an average diameter of 17.9 ± 2.85 nm and 5.4 ± 0.75 nm, respectively. The penetration rate for cells treated with ta...
7 CitationsSource
Background and Purpose: The objective of this study was to investigate the therapeutic effect of Folic Acid-Conjugated polyglycerol coated iron oxide nanoparticles on the radiosensitivity of HeLa cells when irradiated with 6 MeV electron beams. Materials and Methods: Different concentrations of iron oxide nanoparticles (PG-SPIONs and FA-PG-SPIONs (25, 50, 100, 200 µg ml-1)) were synthesized by the thermal decomposition technique. The effect of PG-SPIONs and FA-PG-SPIONs in combination with radia...
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Introduction: The objective of this work was to investigate the therapeutic effect of a combination of hyperthermia at 43oC exposured for 20, 40, 60 min with 6MeV electron beams at different radiation doses (2, 4, 6 Gy) compared to radiation alone. Materials and Methods: In this in vitro study, HeLa cells were exposed to either: 6MeV electron beams at different doses (2, 4, 6 Gy) and hyperthermia at 43oC for 20, 40, 60 min alone or electron beam followed by hyperthermia with 20-minute interval. ...
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#1Keyvan Jabbari (IUMS: Isfahan University of Medical Sciences)H-Index: 6
#2Tinoosh Almasi (IUMS: Isfahan University of Medical Sciences)H-Index: 2
Last. Alireza Amouheidari (Milad Hospital)H-Index: 5
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Introduction: Immobilization of patients in radiation therapy can be performed with a vacuum bag (VB). The aim of this study is to measure the effect of the VB in the surface and depth dose of patients in radiation therapy. Materials and Methods: The effect of the VB on the surface dose and depth dose is measured in clinical conditions. Various dosimeters were used in following measurements: parallel plate chamber for depth dose, farmer ionization chamber for various gantry angles, and Mapcheck2...
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