Said Suleiman
RWTH Aachen University
VasodilationInternal medicineSurgeryPerfusionContraction (grammar)Respiratory physiologyCardiologyHemodynamicsPlatelet-derived growth factor receptorCalcium in biologyChemistryProtein kinase CNeuroprotectionPulmonary edemaMilrinoneGABA receptorLevosimendanNilotinibImatinibLungHeart failureAmlodipinePonatinibProstaglandinPulmonary hypertensionBaclofenLUNG EDEMALeft atrial pressureIn patientIsolated perfused lungLeft heart diseaseAnesthesiaTyrosine kinaseArgonVascular resistanceText miningMedicineProtein kinase BBlood pressurePI3K/AKT/mTOR pathwayCalcium metabolismProtein kinase APharmacology
8Publications
4H-index
59Citations
Publications 9
Newest
#1Annette D. RiegH-Index: 11
#2Said SuleimanH-Index: 4
Last. Christian MartinH-Index: 20
view all 13 authors...
Introduction Levosimendan is approved for acute heart failure. Within this context, pulmonary hypertension represents a frequent co-morbidity. Hence, the effects of levosimendan on segmental pulmonary vascular resistance (PVR) are relevant. So far, this issue has been not studied. Beyond that the relaxant effects of levosimendan in human pulmonary vessel are unknown. We addressed these topics in rats’ isolated perfused lungs (IPL) and human precision-cut lung slices (PCLS). Material and methods ...
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#1Said SuleimanH-Index: 4
#2Christian MartinH-Index: 20
view all 4 authors...
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#1Annette D. Rieg (RWTH Aachen University)H-Index: 11
#2Nina Andrea Bünting (RWTH Aachen University)H-Index: 2
Last. Christian Martin (RWTH Aachen University)H-Index: 19
view all 14 authors...
Background Tyrosine kinase inhibitors (TKIs) inhibit the platelet derived growth factor receptor (PDGFR) and gain increasing significance in the therapy of proliferative diseases, e.g. pulmonary arterial hypertension (PAH). Moreover, TKIs relax pulmonary vessels of rats and guinea pigs. So far, it is unknown, whether TKIs exert relaxation in human and murine pulmonary vessels. Thus, we studied the effects of TKIs and the PDGFR-agonist PDGF-BB in precision-cut lung slices (PCLS) from both species...
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#1Said Suleiman (RWTH Aachen University)H-Index: 4
#2Sergej Klassen (RWTH Aachen University)H-Index: 1
Last. Annette D. Rieg (RWTH Aachen University)H-Index: 11
view all 17 authors...
Argon exerts neuroprotection. Thus, it might improve patients’ neurological outcome after cerebral disorders or cardiopulmonary resuscitation. However, limited data are available concerning its effect on pulmonary vessel and airways. We used rat isolated perfused lungs (IPL) and precision-cut lung slices (PCLS) of rats and humans to assess this topic. IPL: Airway and perfusion parameters, oedema formation and the pulmonary capillary pressure (Pcap) were measured and the precapillary and postcapi...
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#1Annette D. Rieg (RWTH Aachen University)H-Index: 11
#2Said Suleiman (RWTH Aachen University)H-Index: 4
Last. Christian Martin (RWTH Aachen University)H-Index: 19
view all 7 authors...
Platelet-derived growth factor (PDGF)-BB and its receptor PDGFR are highly expressed in pulmonary hypertension (PH) and mediate proliferation. Recently, we showed that PDGF-BB contracts pulmonary veins (PVs) and that this contraction is prevented by inhibition of PDGFR-β (imatinib/SU6668). Here, we studied PDGF-BB-induced contraction and downstream-signalling in isolated perfused lungs (IPL) and precision-cut lung slices (PCLS) of guinea pigs (GPs). In IPLs, PDGF-BB was perfused after or without...
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#1Nina A. Maihöfer (RWTH Aachen University)H-Index: 3
#2Said Suleiman (RWTH Aachen University)H-Index: 4
Last. Annette D. Rieg (RWTH Aachen University)H-Index: 11
view all 8 authors...
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#1Nina A. Maihöfer (RWTH Aachen University)H-Index: 3
#2Said Suleiman (RWTH Aachen University)H-Index: 4
Last. Annette D. Rieg (RWTH Aachen University)H-Index: 11
view all 8 authors...
Background Recently, the IMPRES study revealed that systemic imatinib improves exercise capacity in patients with advanced pulmonary arterial hypertension. Imatinib blocks the tyrosine kinase activity of the platelet-derived growth factor (PDGF)-receptor (PDGFR), acts antiproliferative and relaxes pulmonary arteries. However so far, the relaxant effects of imatinib on pulmonary veins (PVs) and on the postcapillary resistance are unknown, although pulmonary hypertension (PH) due to left heart dis...
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#1Said Suleiman (RWTH Aachen University)H-Index: 4
#2Mark Coburn (RWTH Aachen University)H-Index: 31
Last. Annette D. Rieg (RWTH Aachen University)H-Index: 11
view all 6 authors...
Introduction: Argon exerts neuroprotection [1] and might improve the outcome of patients after cardiopulmonary resuscitation, intracerebral bleeding or traumatic brain injury. In patients suffering from left heart disease (LHD) and pulmonary hypertension (PH), limited data for the effect of argon on the pulmonary vascular resistance (PVR) are available. Recently, Neyrinck et al. showed that argon does not alter total PVR in pigs. Aims and objectives: To study if argon alters segmental PVR, we us...
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#3Alberto Perez-Bouza (University of Bonn)H-Index: 14
#6Thomas SchröderH-Index: 2
Introduction The phosphodiesterase-III inhibitor milrinone improves ventricular contractility, relaxes pulmonary arteries and reduces right ventricular afterload. Thus, it is used to treat heart failure and pulmonary hypertension (PH). However, its action on pulmonary veins (PVs) is not defined, although particularly PH due to left heart disease primarily affects the pulmonary venous bed. We examined milrinone-induced relaxation in PVs from guinea pigs (GPs) and humans. Material and Methods Prec...
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