Ram K. Rohatgi
Mayo Clinic
Loss functionQT intervalInterquartile rangeInternal medicinePhenotypeRepolarizationBenign early repolarizationCardiologyRetrospective cohort studyPediatricsRyanodine receptor 2PenetranceSudden cardiac deathAsymptomaticHeart rateCatecholaminergic polymorphic ventricular tachycardiaBeta blockerConcomitantLong QT syndromeElectrocardiographyMitral valve prolapseUncertain significanceSympathetic DenervationCongenital long QT syndromeIn patientCardiovascular eventClinical phenotypeContractilityGeneticsClinical significanceMedicineCohort
27Publications
8H-index
176Citations
Publications 28
Newest
#1Ram K. Rohatgi (Mayo Clinic)H-Index: 8
#2M. Yasir Qureshi (Mayo Clinic)H-Index: 5
Last. Nathaniel W. Taggart (Mayo Clinic)H-Index: 14
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Source
#1Jessie J. Hu (Mayo Clinic)H-Index: 1
#2Charlotte S. Van Dorn (Mayo Clinic)H-Index: 5
Last. Jonathan N. Johnson (Mayo Clinic)H-Index: 30
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Background: Ebstein anomaly (EA) is a rare congenital heart defect characterized by apical displacement of the tricuspid valve resulting in tricuspid valve (TV) dysfunction and right ventricular myopathy. Cone reconstruction (CR) has become the standard technique for TV repair for most patients with EA. The impact of additional right-sided obstructive lesions (RSOL) on post-operative outcomes in pediatric patients undergoing CR for EA is unknown. Methods: We performed a retrospective review of a...
Source
#1Ciorsti J. MacIntyre (Queen Elizabeth II Health Sciences Centre)H-Index: 3
#1Ciorsti J. MacIntyre (Queen Elizabeth II Health Sciences Centre)H-Index: 7
Last. Michael J. Ackerman (Mayo Clinic)H-Index: 144
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Abstract Background International guidelines advise universal beta blocker therapy as either a class I (symptomatic or QTc > 470 ms) or class II recommendation (asymptomatic and QTc Objective This study sought to evaluate the outcomes of a highly selected cohort of patients with LQTS managed with an observation only (intentional non-treatment) strategy. Methods The cohort was derived using a comprehensive retrospective registry of patients with LQTS. Clinical phenotype and genotype data were col...
5 CitationsSource
#1John R. Giudicessi (Mayo Clinic)H-Index: 22
#2Ram K. Rohatgi (Mayo Clinic)H-Index: 8
Last. Michael J. Ackerman (Mayo Clinic)H-Index: 144
view all 4 authors...
5 CitationsSource
#1Heather N. Anderson (Mayo Clinic)H-Index: 6
#2J. Martijn BosH-Index: 32
Last. Michael J. AckermanH-Index: 144
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Abstract Objectives This study evaluated the effect of left cardiac sympathetic denervation (LCSD) on heart rate, cardiac contractility, and cardiopulmonary fitness in human subjects. Background The primary treatment for long QT syndrome (LQTS) is beta-blocker (BB) therapy, but some patients experience breakthrough cardiac events or intolerable side effects. LCSD provides a significant antifibrillatory, protective effect in LQTS. However, the effect of LCSD on cardiopulmonary fitness in humans h...
1 CitationsSource
#1J. Martijn Bos (Mayo Clinic)H-Index: 32
#2Lia Crotti (University of Milano-Bicocca)H-Index: 8
Last. Michael J. Ackerman (Mayo Clinic)H-Index: 144
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Background: Long QT syndrome is a potentially lethal yet highly treatable cardiac channelopathy. Although β-blocker therapy is standard for most patients, concomitant therapy with sodium channel blockers, like mexiletine, is often utilized for patients with sodium channel–mediated type 3 long QT syndrome (LQT3). The potential role of sodium channel blockers in patients with potassium channel–mediated long QT syndrome (ie, LQT1 and LQT2) has not been investigated in detail. Methods: We performed ...
26 CitationsSource
#1John R. GiudicessiH-Index: 22
#2Krystien V.V. Lieve (UvA: University of Amsterdam)H-Index: 12
Last. Michael J. Ackerman (Mayo Clinic)H-Index: 144
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Background Many rare, potentially pathogenic, RYR2 variants identified in individuals with clinically definite catecholaminergic polymorphic ventricular tachycardia are classified ambiguously as va...
15 CitationsSource
#1Daniel J. Clemens (Mayo Clinic)H-Index: 4
#2David J. Tester (Harvard University)H-Index: 76
Last. Michael J. Ackerman (Mayo Clinic)H-Index: 144
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Background: Triadin knockout syndrome (TKOS) is a rare, inherited arrhythmia syndrome caused by recessive null mutations in TRDN-encoded cardiac triadin. Based previously on 5 triadin null patients...
15 CitationsSource
#1John R. Giudicessi (Mayo Clinic)H-Index: 22
#2Ram K. Rohatgi (Mayo Clinic)H-Index: 8
Last. Michael J. Ackerman (Mayo Clinic)H-Index: 144
view all 4 authors...
Abstract Background Mitral valve prolapse (MVP), including the recently described arrhythmogenic bileaflet MVP syndrome (ABiMVPS), is associated with repolarization abnormalities and may represent an underestimated cause of sudden cardiac death. The impact of concomitant MVP or ABiMVPS on long QT syndrome (LQTS) clinical severity is unknown. Methods and results Retrospective review of 754 LQTS patients [445 females (58%) and mean QTc 471 ± 41 ms] with available echocardiographic data was perform...
5 CitationsSource
#1Conor M. LaneH-Index: 3
#2J. M BosH-Index: 5
Last. Michael J. AckermanH-Index: 144
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Introduction: Despite advances in the diagnosis and management of congenital long QT syndrome (LQTS), predicting the risk of LQTS-triggered cardiac events remains an important challenge. Exercise s...