Frederik Barkhof
VU University Medical Center
Internal medicineRadiologySurgeryPathologyMagnetic resonance imagingHyperintensityPsychologyNeuroscienceCognitionDiseaseCentral nervous system diseaseDementiaMultiple sclerosisAtrophyWhite matterCognitive declineNuclear medicineAlzheimer's diseaseNeuroimagingMedicine
1,789Publications
177H-index
89.6kCitations
Publications 1772
Newest
#1Hugo VrenkenH-Index: 59
#2Mark Jenkinson (University of Oxford)H-Index: 83
Last. M. Jorge Cardoso ('KCL': King's College London)H-Index: 37
view all 11 authors...
Multiple sclerosis (MS) patients have heterogeneous clinical presentations, symptoms and progression over time, making MS difficult to assess and comprehend in vivo. The combination of large-scale data-sharing and artificial intelligence creates new opportunities for monitoring and understanding MS using magnetic resonance imaging (MRI). null First, development of validated MS-specific image analysis methods can be boosted by verified reference, test and benchmark imaging data. Using detailed ex...
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#1Yajing Zhang (Philips)
#2Yunyun Duan (Capital Medical University)H-Index: 23
Last. Yaou Liu (Capital Medical University)H-Index: 21
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Purpose null White matter hyperintensity (WMHI) lesions on MR images are an important indication of various types of brain diseases that involve inflammation and blood vessel abnormalities. Automated quantification of the WMHI can be valuable for the clinical management of patients, but existing automated software is often developed for a single type of disease and may not be applicable for clinical scans with thick slices and different scanning protocols. The purpose of the study is to develop ...
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#1Lorenzini L (VUMC: Vanderbilt University Medical Center)
#2Silvia Ingala (UvA: University of Amsterdam)H-Index: 7
Last. Juan Domingo GispertH-Index: 32
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The European Prevention of Alzheimer Dementia (EPAD) is a multi-center study that aims to characterize the preclinical and prodromal stages of Alzheimer9s Disease. The EPAD imaging dataset includes core (3D T1w, 3D FLAIR) and advanced (ASL, diffusion MRI, and resting-state fMRI) MRI sequences. Here, we give an overview of the semi-automatic multimodal and multisite pipeline that we developed to curate, preprocess, quality control (QC), and compute image-derived phenotypes (IDPs) from the EPAD MR...
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#1Hugh Pemberton (UCL: University College London)H-Index: 4
#2Lara A. M. Zaki (EUR: Erasmus University Rotterdam)
Last. Meike W. Vernooij (EUR: Erasmus University Rotterdam)H-Index: 72
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Non-invasively measured brain activity is related to progression-free survival in glioma patients, suggesting its potential as a marker of glioma progression. We therefore assessed the relationship between brain activity and increasing tumor volumes on routine clinical magnetic resonance imaging (MRI) in glioma patients. Postoperative magnetoencephalography (MEG) was recorded in 45 diffuse glioma patients. Brain activity was estimated using three measures (absolute broadband power, offset and sl...
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#1Dan Cheng (Capital Medical University)
#2Xiang Shang (Capital Medical University)
Last. Yaou Liu (Capital Medical University)H-Index: 21
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Objectives: null To identify fetal familial cerebral cavernous malformation (CCMs) and a novel mutation. null Methods: null A 37-year-old pregnant woman (G4P0) presented right-handed numbness since two weeks at 31 weeks of gestation. Evaluation with brain magnetic resonance imaging (MRI) revealed multiple CCMs. As a result, fetal MRI, fetal Whole Exome Sequencing (WES), and maternal Sanger sequencing were performed. null Results: null The mother’s brain MRI demonstrated numerous CCMs involving t...
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#1Sara ColloroneH-Index: 5
#2Baris Kanber (UCL: University College London)H-Index: 11
Last. Ahmed T. ToosyH-Index: 29
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Background null In this study, we hypothesized that clinically isolated syndrome-optic neuritis patients may have disturbances in neuropsychological functions related to visual processes. null Methods null Forty-two patients with optic neuritis within 3 months from onset and 13 healthy controls were assessed at baseline and 6 months with MRI (brain volumes, lesion load, and optic radiation lesion volume) and optical coherence tomography (OCT) (peripapillary retinal nerve fiber layer [RNFL], gang...
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For patients with presumed glioblastoma, essential tumor characteristics are determined from preoperative MR images to optimize the treatment strategy. This procedure is time-consuming and subjective, if performed by crude eyeballing or manually. The standardized GSI-RADS aims to provide neurosurgeons with automatic tumor segmentations to extract tumor features rapidly and objectively. In this study, we improved automatic tumor segmentation and compared the agreement with manual raters, describe...
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#1Claire Bridel (Geneva College)H-Index: 6
#2Cyra E. LeursH-Index: 11
Last. Joep KillesteinH-Index: 53
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ObjectiveThe objective of this study was to investigate the potential of serum neurofilament light (NfL) to reflect or predict progression mostly independent of acute inflammatory disease activity in patients with relapsing remitting multiple sclerosis (RRMS) treated with natalizumab.MethodsPatients were selected from a prospective observational cohort study initiated in 2006 at the VU University Medical Center Amsterdam, The Netherlands, including patients with RRMS treated with natalizumab. Se...
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#1Hugh Pemberton (UCL: University College London)H-Index: 4
#2Lara A. M. Zaki (EUR: Erasmus University Rotterdam)
Last. Meike W. Vernooij (EUR: Erasmus University Rotterdam)H-Index: 72
view all 7 authors...
Developments in neuroradiological MRI analysis offer promise in enhancing objectivity and consistency in dementia diagnosis through the use of quantitative volumetric reporting tools (QReports). Translation into clinical settings should follow a structured framework of development, including technical and clinical validation steps. However, published technical and clinical validation of the available commercial/proprietary tools is not always easy to find and pathways for successful integration ...
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