Zhicheng Peng
Jilin University
Caspase 3Internal medicinePeroxisomeEndocrinologyKinaseChemistryApoptosisIn vitroAutophagyHaptoglobinSuperoxide dismutaseOxidative stressKetosisInflammasomeInsulin resistanceMalondialdehydeGlutathione peroxidaseFatty liverNEFAMitochondrionBlood chemistryLipotoxicityLipid metabolismSerum amyloid AOxidative phosphorylationMetabolismIntracellularBiology
16Publications
9H-index
470Citations
Publications 16
Newest
#1Xinwei Li (JLU: Jilin University)H-Index: 23
#2Zhen Shi (JLU: Jilin University)H-Index: 10
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 15 authors...
BACKGROUND AND PURPOSE: Identifying safe and effective compounds that target to mitophagy to eliminate impaired mitochondria may be an attractive therapeutic strategy for NAFLD. Here, we investigated the effects of cyanidin-3-O-glucoside (C3G) on NAFLD and the underlying mechanism. EXPERIMENTAL APPROACH: NAFLD was induced by a high-fat diet (HFD) for 16 weeks. C3G was administered during the last 4 weeks. In vivo, recombinant adenoviruses and AAV8 were used for overexpression and knockdown of PT...
6 CitationsSource
#1Xinwei Li (JLU: Jilin University)H-Index: 23
#2Guojin Li (JLU: Jilin University)H-Index: 2
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 11 authors...
ABSTRACT Hyperketonemia is a metabolic disease in dairy cows, associated with negative nutrition balance (NNB) induced by low dry matter intake (DMI) and increased nutrient requirements. Hyperketonemia could induce metabolic stress, which might indirectly affect mammary tissue. Autophagy is a highly conserved physiological process that results in the turnover of intracellular material, and is involved in maintaining cellular homeostasis under the challenge of metabolic stress induced by NNB. The...
5 CitationsSource
#1Chenxu Zhao (JLU: Jilin University)H-Index: 11
#2Yazhou Wang (JLU: Jilin University)H-Index: 3
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 8 authors...
: Subacute ruminal acidosis (SARA) is characterized by the depression of ruminal pH and an increase in the concentrations of short-chain fatty acids (SCFAs) and lipopolysaccharide (LPS) in the rumen of cows. The onset of SARA was linked to the accumulation of SCFAs. However, the mechanism of SCFAs transport is unknown. The proton-linked monocarboxylate transporter (MCT1) plays a vital role in the transportation of SCFAs. The goal of this study was to elucidate the distribution of MCT1 along the ...
5 CitationsSource
#1Zhicheng PengH-Index: 9
#2Xiaobing LiH-Index: 22
Last. Xinwei LiH-Index: 23
view all 5 authors...
: Dairy cows with ketosis display severe oxidative stress as well as high blood concentrations of non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHB). Cytochrome P4502E1 (CYP2E1) plays an important role in the induction of oxidative stress. The aim of this study was to investigate CYP2E1 expression and activity in the liver of clinically ketotic cows (in vivo) and the effects of NEFA and BHB on CYP2E1 expression and activity in hepatocytes (in vitro). Dairy cows with clinical ketosis e...
1 CitationsSource
#1Zhicheng Peng (JLU: Jilin University)H-Index: 9
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 7 authors...
: The NOD‑like receptor family pyrin domain containing 3 (NLRP3) inflammasome has been reported to contribute to palmitic acid (PA)‑induced lipotoxicity. Nobiletin (Nob) is a polymethoxylated flavonoid derived from citrus fruits that has been reported to exert antioxidant and antitumor effects. However, its protective and regulatory mechanisms in PA‑induced lipotoxicity remain unclear. Therefore, the aim of the present study was to investigate the protective effects of Nob in AML‑12 cells agains...
4 CitationsSource
#1Xiliang Du (JLU: Jilin University)H-Index: 12
#2Taiyu Shen (JLU: Jilin University)H-Index: 5
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 16 authors...
ABSTRACT The inevitable deficiency in nutrients and energy at the onset of lactation requires an optimal adaptation of the hepatic metabolism to overcome metabolic stress. Fatty liver is one of the main health disorders after parturition. Therefore, to investigate changes in hepatic lipid metabolic status and mitochondria in dairy cows with mild fatty liver, liver and blood samples were collected from healthy cows (n = 15) and cows with mild fatty liver (n = 15). To determine the effects of palm...
34 CitationsSource
#1Zhen ShiH-Index: 10
#2Xiaobing LiH-Index: 22
Last. Xinwei LiH-Index: 23
view all 10 authors...
Fatty liver is a major lipid metabolic disease in perinatal dairy cows and is characterized by high blood levels of non-esterified fatty acid (NEFA) and insulin resistance. Berberine (BBR) has been reported to improve insulin sensitivity in mice with hepatic steatosis. Mitochondrial dysfunction is considered a causal factor that induces insulin resistance. This study investigates the underlying mechanism and the beneficial effects of BBR on mitochondrial and insulin signaling in bovine hepatocyt...
4 CitationsSource
#1Xiliang Du (JLU: Jilin University)H-Index: 12
#2Yiwei Zhu (JLU: Jilin University)H-Index: 9
Last. Guowen Liu (JLU: Jilin University)H-Index: 27
view all 14 authors...
ABSTRACT The hepatic growth hormone (GH)–insulin-like growth factor (IGF)-I axis is essential for regulating intrahepatic lipid metabolism. Ketotic cows are characterized by high blood concentrations of fatty acids and β-hydroxybutyrate (BHB), which display lipotoxicity. The aim of this study was to investigate changes in the hepatic GH–IGF-I axis in ketotic cows and to determine the effects of fatty acids and BHB on the GH–IGF-I axis in calf hepatocytes. Liver and blood samples were collected f...
49 CitationsSource
#1Xiliang Du (JLU: Jilin University)H-Index: 12
#2Guowen Liu (JLU: Jilin University)H-Index: 27
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 17 authors...
ABSTRACT The ability of liver to respond to changes in nutrient availability is essential for the maintenance of metabolic homeostasis. Autophagy encompasses mechanisms of cell survival, including capturing, degrading, and recycling of intracellular proteins and organelles in lysosomes. During negative nutrient status, autophagy provides substrates to sustain cellular metabolism and hence, tissue function. Severe negative energy balance in dairy cows is associated with fatty liver. The aim of th...
11 CitationsSource
#1Yuming Zhang (JLU: Jilin University)H-Index: 8
#2Xiaobing Li (JLU: Jilin University)H-Index: 22
Last. Xinwei Li (JLU: Jilin University)H-Index: 23
view all 8 authors...
BACKGROUND/AIMS: Dairy cows with clinical ketosis display a negative energy balance and high blood concentrations of non-esterified fatty acids (NEFAs), the latter of which is an important pathological factor of ketosis in cows. The aims of this study were to investigate the inflammatory status of ketotic cows and to determine whether and through what underlying mechanism high levels of NEFAs induce an inflammatory response. METHODS: Proinflammatory factors and the nuclear factor kappa B (NF-κB)...
12 CitationsSource