Hekai Li
Southern Medical University
CellCardiologyReceptorChemistryMesenchymal stem cellIn vivoStem-cell therapyAngiogenesisFibrosisPeptide YYStem cellParacrine CommunicationTransplantationMyocardial infarctionCancer researchMedicineParacrine signallingBiologyNeuropeptide Y receptorPharmacology
10Publications
6H-index
105Citations
Publications 9
Newest
#1Anbiao Wu (Southern Medical University)
#2Lihong Zhang (Southern Medical University)
Last. Qicai Liu (Southern Medical University)H-Index: 3
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Cardiac fibrosis is an important pathological change after myocardial infarction (MI). Its progression is essential for post-MI infarct healing, during which transforming growth factor beta1 (TGF-β1) plays a critical role. Limb-bud and Heart (LBH), a newly discovered target gene of TGF-β1, was shown to promote normal cardiogenesis. αB-crystallin (CRYAB), an LBH-interacting protein, was demonstrated to be involved in TGF-β1-induced fibrosis. The roles and molecular mechanisms of LBH and CRYAB dur...
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#1Zhanpeng Wen (Southern Medical University)H-Index: 1
Last. Minsheng ChenH-Index: 16
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#1Long GaoH-Index: 7
#2Min Yi (Guangzhou Medical University)H-Index: 1
Last. Jiang ChangH-Index: 89
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Stem cells therapy has been proved as a promising strategy for myocardial infarction (MI) treatment. However, the therapeutic efficacy is mainly limited by cellular activity of transplanted mesenchymal stem cells (MSCs). In this study, a novel bioglass (BG)/γ-polyglutamic acid (γ-PGA)/chitosan (CS) hydrogel was obtained by in situ adding BG to stimulate the imine bonds formation. And the effect of the composite hydrogel on MI therapeutic efficacy was evaluated in a rat acute myocardial infarctio...
3 CitationsSource
#1Min YiH-Index: 2
#2Hekai Li (Southern Medical University)H-Index: 6
Last. Minsheng Chen (Southern Medical University)H-Index: 16
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: Although numerous therapies are widely applied clinically and stem cells and/or biomaterial based in situ implantations have achieved some effects, few of these have observed robust myocardial regeneration. The beneficial effects on cardiac function and structure are largely acting through paracrine signaling, which preserve the border-zone around the infarction, reduce apoptosis, blunt adverse remodeling, and promote angiogenesis. Ionic extracts from biomaterials have been proven to stimulate...
11 CitationsSource
#1Hekai Li (Southern Medical University)H-Index: 6
#2Jie Gao (NKU: Nankai University)H-Index: 17
Last. Minsheng Chen (Southern Medical University)H-Index: 16
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Stem cell therapy has obtained extensive consensus to be an effective method for post myocardial infarction (MI) intervention. Induced pluripotent stem (iPS) cells, which are able to differentiate into multiple cell types, have the potential to generate cardiovascular lineage cells for myocardial repair after ischemic damage, but their poor retention rate significantly hinders the therapeutic efficacy. In the present study, we developed a supramolecular hydrogel which is formed by the self-assem...
19 CitationsSource
#1Min Yi (Southern Medical University)H-Index: 2
#2Hekai Li (Southern Medical University)H-Index: 6
Last. Minsheng Chen (Southern Medical University)H-Index: 16
view all 7 authors...
Human neuropeptide Y (hNPY) is one of the most widely expressed neurotransmitters in the human central and peripheral nervous systems. It consists of 36 highly conserved amino acid residues, and was f
33 CitationsSource
#1Zhiye Wu (Southern Medical University)H-Index: 11
#2Guoqin ChenH-Index: 5
Last. Caiwen Ou (Southern Medical University)H-Index: 14
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The effect of transplanted rat mesenchymal stem cells (MSCs) can be reduced by extracellular microenvironment in myocardial infarction (MI). We tested a novel small-molecular hydrogel (SMH) on whether it could provide a scaffold for hepatocyte growth factor (HGF)-modified MSCs and alleviate ventricular remodeling while preserving cardiac function after MI. Overexpression of HGF in MSCs increased Bcl-2 and reduced Bax and caspase-3 levels in response to hypoxia in vitro. Immunocytochemistry demon...
21 CitationsSource
#1Xiao-Bin Ni (Southern Medical University)H-Index: 2
#2Caiwen Ou (Southern Medical University)H-Index: 14
Last. Minsheng Chen (Southern Medical University)H-Index: 16
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: Mesenchymal stem cell (MSC) transplantation has emerged as a promising therapy for ischemic heart disease; however, the low survival rate of transplanted cells limits their therapeutic efficacy. The aim of this study was to investigate whether the dual genetic modification of vascular endothelial growth factor (VEGF) and B‑cell lymphoma‑2 (Bcl‑2) confers a higher expression level of the target genes, better survival and a stronger paracrine effect in MSCs in an adverse environment than the mod...
14 CitationsSource
#1Anqing Huang (Southern Medical University)H-Index: 4
#2Caiwen Ou (Southern Medical University)H-Index: 14
Last. Minsheng Chen (Southern Medical University)H-Index: 16
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We report a strategy of in situ forming supramolecular nanofibers of taxol-phosphorylated peptide conjugates catalyzed by phosphatase for efficiently killing cancer cells.
14 CitationsSource