Jian-Hong Zhou
Guangzhou University of Chinese Medicine
Internal medicineDownregulation and upregulationEndocrinologymicroRNACellMolecular biologyChemistryApoptosisMesenchymal stem cellWestern blotLipopolysaccharidePaeonolHMGB1OncogeneStem cellLung injuryCell growthSignal transductionMedicineBiologyCell biologyPharmacology
35Publications
11H-index
372Citations
Publications 35
Newest
#1Jun Zhong (Guangzhou University of Chinese Medicine)H-Index: 1
#2Sen Ye (Guangzhou University of Chinese Medicine)H-Index: 2
Last. Caixia Li (Guangzhou University of Chinese Medicine)
view all 9 authors...
In recent years, stem cells have gained much attention for the treatment of neurodegenerative diseases. However, inducing neural stem cell directionally differentiation is a difficult problem in the treatment of Parkinson's disease (PD) by stem cell therapy. Plastrum Testudinis (PT) can enhance the number of TH-positive neurons in the PD rat brain substantia nigra, but the underlying mechanism has not been clarified. Here, we aimed at further investigating the mechanism by which PT can promote N...
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#1Liyan Mei (Guangzhou University of Chinese Medicine)H-Index: 5
#2Meihong He (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Hui Li (Guangzhou University of Chinese Medicine)H-Index: 17
view all 17 authors...
Sepsis is a life-threatening disease caused by infection. Inflammation is a key pathogenic process in sepsis. Paeonol, an active ingredient in moutan cortex (a Chinese herb), has many pharmacological activities, such as anti-inflammatory and antitumour actions. Previous studies have indicated that paeonol inhibits the expression of HMGB1 and the transcriptional activity of NF-κB. However, its underlying mechanism is still unknown. In this study, microarray assay and reverse transcription-quantit...
6 CitationsSource
#1Xia Liu (Guida: Guizhou University)H-Index: 2
#2Fei Ai (Guida: Guizhou University)H-Index: 1
Last. Junfeng Guo (Guida: Guizhou University)H-Index: 1
view all 13 authors...
Shenfu injection (SFI), a Chinese herbal medicine with substances extracted from Ginseng Radix et Rhizoma Rubra and Aconiti Lateralis Radix Praeparata, is widely used as an anti-inflammatory reagent to treat endotoxin shock in China. However, the mechanism of SFI in endotoxin shock remains to be illuminated. High mobility group box 1 (HMGB1), a vital inflammatory factor in the late stage of endotoxin shock, may stimulate multiple signalling cascades, including κB (NF-κB), a nuclear transcription...
8 CitationsSource
#1Xin Liu (Guangzhou University of Chinese Medicine)H-Index: 2
#2Ruilin Zhang (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
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: Forkhead box P2 (Foxp2) is a transcription factor involved in vocal learning. However, the number of previous studies that have investigated the role of Foxp2 in early vascular dementia (VD) is limited. The aim of the present study was to determine whether microRNA (miR)‑134‑5p/Foxp2 contributes to cognitive impairment in a chronic ischemia‑induced early VD model. miR‑134‑5p was found to be significantly increased in the cortex in a rat VD model. Intracerebroventricular injection of miR‑134‑5p...
4 CitationsSource
#1Wenwen Si (Guangzhou University of Chinese Medicine)H-Index: 4
#2Shanyu Ye (Guangzhou University of Chinese Medicine)H-Index: 3
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 11 authors...
: Under harmful environmental conditions, stress granules (SGs), macromolecular aggregates that are associated with cell survival and death, are produced in the eukaryotic cytoplasm. However, whether and how microRNAs (miRNAs/miRs) modulate SG formation induced by acute ischemic stroke has not been investigated. In the present study, a rat model of middle cerebral artery occlusion (MCAO) was utilized and miRNA array profiling and reverse transcription‑quantitative polymerase chain reaction were p...
8 CitationsSource
#1Zhenxing Ren (Guangzhou University of Chinese Medicine)H-Index: 5
#2Junlong Yu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Dongfeng Chen (Guangzhou University of Chinese Medicine)H-Index: 22
view all 9 authors...
Vascular dementia (VD) is the most common form of dementia in the elderly. However, little is understood about the role of microRNAs (miRNAs) involved in cognitive impairment in early VD. Here, VD model induced by chronic cerebral ischemia and FBS-free cell model detecting synapse formation were established to investigate the function of microRNAs in early VD. Microarray analysis and real-time reverse transcription PCR showed that miR-210-5p increased significantly in the hippocampus of rat with...
15 CitationsSource
#1Xiang-Jun Li (Guangzhou University of Chinese Medicine)H-Index: 1
#2Yuqiong Wu (Guangzhou University of Chinese Medicine)H-Index: 1
Last. Aijun Liu (Guangzhou University of Chinese Medicine)H-Index: 3
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: Our previous study indicated that loureirin A induces hair follicle stem cell (HFSC) differentiation through Wnt/β‑catenin signaling pathway activation. However, if and how microRNAs (miRNAs/miRs) modulate loureirin A‑induced differentiation remains to be elucidated. In the present study, HFSCs were separated from the vibrissae of rats and identified by CD34 and keratin, type 1 cytoskeletal (K)15 expression. Microarray‑based miRNA profiling analysis revealed that miR‑339‑5p was downregulated i...
8 CitationsSource
#1Xia Liu (Guangzhou University of Chinese Medicine)H-Index: 4
#2Qin Xu (Guangzhou University of Chinese Medicine)H-Index: 5
Last. Hui Li (Guangzhou University of Chinese Medicine)H-Index: 17
view all 15 authors...
Abstract High-mobility group box 1 (HMGB1) is a highly conserved DNA-binding nuclear protein that facilitates gene transcription and the DNA repair response. However, HMGB1 may be released by necrotic cells as well as activated monocytes and macrophages following stimulation with lipopolysaccharide (LPS), interleukin-1β (IL-1β), or tumor necrosis factor-α (TNF-α). Extracellular HMGB1 plays a critical role in the pathogenesis of acute lung injury (ALI) through activating the nuclear transcription...
15 CitationsSource
#1Qin Xu (Guangzhou University of Chinese Medicine)H-Index: 5
#2Xia Liu (Guangzhou University of Chinese Medicine)H-Index: 4
Last. Hui Li (Guangzhou University of Chinese Medicine)H-Index: 17
view all 17 authors...
Extracellular high mobility group box 1 (HMGB1) is a lethal pro-inflammatory mediator in endotoxin shock. Hyperacetylation of HMGB1, regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), changes its subcellular localization and secretion to the extracellular matrix. Paeonol (2′-hydroxy-4′-methoxyacetophenone), one of the main active components of Paeonia suffruticosa, exerts anti-inflammatory effects. Our previous study demonstrated that Paeonol inhibited the relocatio...
6 CitationsSource
#1Yuqing Liu (GU: Guangzhou University)H-Index: 2
#1Yuqing Liu (GU: Guangzhou University)H-Index: 1
Last. Dong-Feng Chen (GU: Guangzhou University)H-Index: 6
view all 10 authors...
: Ischemic strokes carry a significant risk of mortality and recurrent vascular events. Recent studies suggest that changes in microRNAs (miRNAs or miRs) may affect the development of the stroke. However, few studies have investigated the role of miRNAs in behavioral disorder in early stroke. In the present study, animal models of middle cerebral artery occlusion (MCAO) are used, as well as a cell model of neurite outgrowth to further investigate the role of miRNAs in targeting synapse-associate...
3 CitationsSource