Yu-Ri Lee
Chungnam National University
GeneBioassayAnatomyBiophysicsPhenotypeVascular endothelial growth factor AMolecular biologySmall moleculeEnzymeChemistryIn vitroIn vivoLipid dropletLeukodystrophyZebrafishVascular endothelial growth factorIC50NeovascularizationBlood–brain barrierDiabetic retinopathyAngiogenesisRetinalZebrafish larvaeTube formationMutationGeneticsBiochemistryMedicineProanthocyanidinCell cultureBiologyFluorescenceCell biologyPharmacology
19Publications
10H-index
187Citations
Publications 20
Newest
#1Joo-Yeon Lim (CNU: Chungnam National University)H-Index: 4
#2Yeon Ju Kim (CNU: Chungnam National University)H-Index: 4
Last. Hee-Moon Park (CNU: Chungnam National University)H-Index: 16
view all 7 authors...
The LAMMER kinase in eukaryotes is a well-conserved dual-specificity kinase. Aspergillus species cause a wide spectrum of diseases called aspergillosis in humans, depending on the underlying immune status of the host, such as allergy, aspergilloma, and invasive aspergillosis. Aspergillus fumigatus is the most common opportunistic fungal pathogen that causes invasive aspergillosis. Although LAMMER kinase has various functions in morphology, development, and cell cycle regulation in yeast and fila...
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#1Yu-Ri Lee (CNU: Chungnam National University)H-Index: 10
#2Se Hee Kim (Boston Children's Hospital)H-Index: 12
Last. Sangkyu Lee (KNU: Kyungpook National University)H-Index: 24
view all 20 authors...
Leukodystrophy with Vanishing White Matter (VWM), also called Childhood Ataxia with Central Nervous System Hypomyelination (CACH), is caused by mutations in the subunits of the eukaryotic translation initiation factor, EIF2B1, EIF2B2, EIF2B3, EIF2B4, or EIF2B5. However, little is known regarding the underlying pathogenetic mechanisms, and there is no curative treatment for VWM. In this study, we established the first EIF2B3 animal model for VWM disease in vertebrates by CRISPR mutagenesis of the...
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#1Doeun Kim (KNU: Kyungpook National University)H-Index: 2
#2Yu-Ri Lee (CNU: Chungnam National University)H-Index: 10
Last. Sangkyu Lee (KNU: Kyungpook National University)H-Index: 24
view all 7 authors...
Vanishing white matter (VWM) disease is a genetic leukodystrophy leading to severe neurological disease and early death. VWM is caused by bi-allelic mutations in any of the five genes encoding the subunits of the eukaryotic translation factor 2B (EIF2B). Previous studies have attempted to investigate the molecular mechanism of VWN by constructing models for each subunit of EIF2B that causes VWM disease. The underlying molecular mechanisms of the way in which mutations in EIF2B3 result in VWM are...
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#1Tae-Young Choi (Wonkwang University)H-Index: 17
#2Tae-Ik Choi (CNU: Chungnam National University)H-Index: 6
Last. Cheol-Hee Kim (CNU: Chungnam National University)H-Index: 46
view all 5 authors...
Zebrafish have several advantages compared to other vertebrate models used in modeling human diseases, particularly for large-scale genetic mutant and therapeutic compound screenings, and other biomedical research applications. With the impactful developments of CRISPR and next-generation sequencing technology, disease modeling in zebrafish is accelerating the understanding of the molecular mechanisms of human genetic diseases. These efforts are fundamental for the future of precision medicine b...
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#1Ted Inpyo Hong (CNU: Chungnam National University)H-Index: 3
#2Seo-Gu Kang (CNU: Chungnam National University)
Last. Cheol-Hee Kim (CNU: Chungnam National University)H-Index: 46
view all 6 authors...
Copper has demonstrated utility in multiple industrial applications for its high conductivity and antibacterial/antiviral properties. However, numerous findings have suggested potential hazards regarding pathogenesis. This study was conducted to demonstrate the application of zebrafish (Danio rerio) as a cost-effective biological assay to detect environmental pollution, i.e., heavy metal of coins. We demonstrated that zebrafish larvae exposed to copper-plated coins or copper (II) ion solution el...
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#1Maryam Aisyah Abdullah (UPM: Universiti Putra Malaysia)H-Index: 1
#2Yu-Ri Lee (CNU: Chungnam National University)H-Index: 10
Last. Cheol-Hee Kim (CNU: Chungnam National University)H-Index: 46
view all 10 authors...
Abstract A series of aminated- (1-9) and sulfonamide-containing diarylpentadienones (10-18) were synthesized, structurally characterized, and evaluated for their in vitro anti-diabetic potential on α-glucosidase and DPP-4 enzymes. It was found that all the new molecules were non-associated PAINS compounds. The sulfonamide-containing series (compounds 10-18) selectively inhibited α-glucosidase over DPP-4, in which compound 18 demonstrated the highest activity with an IC50 value of 5.69 ± 0.5 µM t...
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#10Karen W. Gripp (Alfred I. duPont Hospital for Children)H-Index: 47
Intellectual disability (ID) is a heterogeneous clinical entity and includes an excess of males who harbor variants on the X-chromosome (XLID). We report rare FAM50A missense variants in the original Armfield XLID syndrome family localized in Xq28 and four additional unrelated males with overlapping features. Our fam50a knockout (KO) zebrafish model exhibits abnormal neurogenesis and craniofacial patterning, and in vivo complementation assays indicate that the patient-derived variants are hypomo...
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#1Yu-Ri LeeH-Index: 10
#2Seung-Hyun JungH-Index: 2
Last. Jin Sook KimH-Index: 35
view all 0 authors...
#1Seong Soon KimH-Index: 6
#2So Hee ImH-Index: 4
Last. Myung Ae BaeH-Index: 19
view all 17 authors...
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#1Kyu-Seok HwangH-Index: 6
#2Jung Yoon YangH-Index: 5
Last. Myung Ae BaeH-Index: 19
view all 11 authors...
Abstract Background The demand for anti-melanogenic agents is increasing due to the unwanted side effects of current treatments. To find an effective anti-melanogenic agent, we used zebrafish as a whole animal model for phenotype-based drug and cosmetic discovery screening. Objectives The aim of this study was to identify and explore a small molecule that could be used for skin-whitening cosmetics. Methods Using zebrafish embryos, we examined the effects of 1000 compounds on zebrafish developmen...
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