Pakama Mahlumba
University of the Witwatersrand
CytotoxicityTargeted drug deliveryNuclear chemistryDynamic light scatteringFourier transform infrared spectroscopyChemistryParticle sizeScanning electron microscopePeptideDrug deliveryTissue invasionStimuli responsiveLarge sizeThermogravimetric analysisBioinformaticsUltraviolet visible spectroscopyMedicineCoacervatePharmacology
2Publications
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17Citations
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The demand for biodegradable sustained release carriers with minimally invasive and less frequent administration properties for therapeutic proteins and peptides has increased over the years. The purpose of achieving sustained minimally invasive and site-specific delivery of macromolecules led to the investigation of a photo-responsive delivery system. This research explored a biodegradable prolamin, zein, modified with an azo dye (DHAB) to synthesize photo-responsive azoprolamin (AZP) nanospher...
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#1Pakama Mahlumba (University of the Witwatersrand)H-Index: 1
#2Yahya E. Choonara (University of the Witwatersrand)H-Index: 34
Last. Viness Pillay (University of the Witwatersrand)H-Index: 38
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Therapeutic proteins and peptides have become notable in the drug delivery arena for their compatibility with the human body as well as their high potency. However, their biocompatibility and high potency does not negate the existence of challenges resulting from physicochemical properties of proteins and peptides, including large size, short half-life, capability to provoke immune responses and susceptibility to degradation. Various delivery routes and delivery systems have been utilized to imp...
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