Yuanyuan Deng
EndocrinologyTumor necrosis factor alphaChemistryPeroxisome proliferator-activated receptorNeuroprotectionInflammationNF-?BADAM10NeurotoxicityMicrogliaReperfusion injurySodium hydrosulfideIcariinAmyloid precursor proteinMorris water navigation taskIschemiaMAPK/ERK pathwayMedicineNeuroinflammationPharmacology
22Publications
12H-index
351Citations
Publications 18
Newest
#1Yuanyuan DengH-Index: 12
Last. Qi-Hai GongH-Index: 21
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Reperfusion therapy is an effective way to rescue cerebral ischemic injury, but this therapy also shows the detrimental risk of devastating disorders and death due to the possible inflammatory responses involved in the pathologies. Hence, the therapy of ischemia/reperfusion (I/R) injury is a great challenge currently. Isorhynchophylline (IRN), a tetracyclic oxindole alkaloid extracted from U. rhynchophylla, has previously shown neuroprotective and anti-inflammatory effects in microglial cells. T...
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#1Yuanyuan Deng (Zunyi Medical College)H-Index: 12
#1Yuanyuan DengH-Index: 1
Last. Qihai GongH-Index: 1
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Cu-Zhi-Yi-Hao (CZYH), an empirical formula of traditional Chinese medicine (TCM), has been used for amnesia treatment in clinical practice. However, its underlying pharmacological mechanism has not been fully illuminated. The current study was designed to investigate the neuroprotective effect of CZYH on a β-amyloid 25-35- (Aβ25-35-) induced learning and memory deficit rat model. CZYH (200, 400, or 800 mg/kg), donepezil (1.0 mg/kg), or distilled water was given to Aβ25-35-stimulated animals for ...
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#1Jiayin ZhouH-Index: 2
#2Yuanyuan Deng (Zunyi Medical College)H-Index: 12
Last. Qihai GongH-Index: 1
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Abstract Inflammation in central nervous system (CNS) plays a vital role in neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Lewy body dementia (DLB), HIV-related dementia and traumatic brain injury. Icariside II (ICS II), an active flavonoid compound derived from a Chinese herbal medicine Epimedium brevicornum Maxim, has been shown to possess a neuroprotective effect on AD model. However, whether ICS II has a directly protective effect on acute neuroinflamm...
21 CitationsSource
: Cu‑zhi‑2‑hao‑fang (CZ2HF), a traditional Chinese medicine, has been used clinically for the treatment of amnesia. However, whether CZ2HF is capable of alleviating learning and memory impairment in Alzheimer's disease (AD) remains to be elucidated. The present study was designed to explore the effect and mechanism of CZ2HF on β‑amyloid 25‑35 (Aβ25‑35)‑induced impairment in the learning and memory of rats. Morris water maze test was used to determine spatial learning and memory ability in Aβ25‑3...
2 CitationsSource
#1Caixia YinH-Index: 7
#2Yuanyuan Deng (Zunyi Medical College)H-Index: 12
Last. Qihai GongH-Index: 1
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Chronic cerebral hypoperfusion (CCH) is regarded as a high-risk factor for cognitive decline of vascular dementia (VD) as it is conducive to induce beta-amyloid (Aβ) aggregation. Icariside II (ICS II), a plant-derived flavonoid compound, has showed neuroprotective effect on animal models of Alzheimer’s disease (AD) by decreasing Aβ levels. Here, we assessed the effect of ICS II on CCH-induced cognitive deficits and Aβ levels in rats, and the possible underlying mechanisms were also explored. It ...
20 CitationsSource
#1Lianzi HeH-Index: 2
#2Yuanyuan Deng (Zunyi Medical College)H-Index: 12
Last. Qi-Hai Gong (Zunyi Medical College)H-Index: 21
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Abstract Background Excitotoxicity is extensively recognized as a major pathological process of neuronal death and has been proved to play a key role in Alzheimer's disease (AD). ICS II, a flavonoid compound from Herba Epimedii Maxim, is attracting great interests due to its neuroprotective properties. Purpose The present study was aimed to explore the effects of ICS II on cognitive dysfunction and apoptotic response induced by excitatory neurotoxin ibotenic acid (IBO) injection in rats. Methods...
10 CitationsSource
#1Lingli YanH-Index: 2
#2Yuanyuan Deng (Zunyi Medical College)H-Index: 12
Last. Qi-Hai GongH-Index: 2
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Abstract: Icariside II (ICS II) is a broad-spectrum anti-cancer natural compound extracted from Herba Epimedii Maxim. Recently, the role of ICS II has been investigated in central nervous system, especially have a neuroprotective effect in Alzheimer's disease (AD). In this study, we attempted to investigate the effects of ICS II, on cognitive deficits and beta-amyloid (Aβ) production in APPswe/PS1dE9 (APP/PS1) double transgenic mice. It was found that chronic ICS II administrated not only effect...
21 CitationsSource
#1Yuangui LiuH-Index: 9
#2Yuanyuan DengH-Index: 12
Last. Qi-Hai GongH-Index: 21
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3 CitationsSource
#1Jianmei GaoH-Index: 9
#2Yuanyuan Deng (Zunyi Medical College)H-Index: 12
Last. Qihai GongH-Index: 5
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Oxidative stress is a major cause of cellular injury in a variety of human diseases including neurodegenerative disorders. Thus, removal of excessive reactive oxygen species (ROS) or suppression of ROS generation may be effective in preventing oxidative stress-induced cell death. This study was designed to investigate the effect of icariside II (ICS II), a novel phosphodiesterase 5 inhibitor, on hydrogen peroxide (H2O2)-induced death of highly differentiated rat neuronal PC12 cells, and to furth...
15 CitationsSource
#1Bo LiuH-Index: 4
#2Fei Li (Zunyi Medical College)H-Index: 13
Last. Qihai GongH-Index: 2
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Gastrodin (GAS), which is extracted from the Chinese herbal medicine Gastrodia elata Blume, has long been used to improve stroke, epilepsy, dizziness and dementia. However, the effects and underlying mechanisms of GAS on subacute phase cerebral ischemia-reperfusion (I/R) injury remain unknown. The aim of the present study was to investigate the effects and mechanisms of GAS on cerebral I/R injury in rats. The rats were pretreated with GAS by gavage for 7 days followed by I/R surgery, and were th...
31 CitationsSource