Taeshin Kim
University of California, San Diego
SpermatogenesisCaspase 3Internal medicineEndocrinologyUnfolded protein responseGene expressionMolecular biologyEndoplasmic reticulumRegulation of gene expressionGene knockdownChemistryApoptosisGonadotropic cellStimulationHuman chorionic gonadotropinGonadotropinGonadotropin-releasing hormoneATF6Anterior pituitaryXBP1TransfectionSignal transductionPolysomeHormoneIntracellularBiologyCell biology
12Publications
7H-index
191Citations
Publications 13
Newest
#1Taeshin Kim (UCSD: University of California, San Diego)H-Index: 7
#2Danmei Li (UCSD: University of California, San Diego)H-Index: 7
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 7 authors...
: A defining characteristic of the hypothalamus-pituitary-gonad reproductive endocrine axis is the episodic secretion of the pituitary gonadotropin hormones LH and FSH by the anterior pituitary gonadotropes. Hormone secretion is dictated by pulsatile stimulation, with GnRH released by hypothalamic neurons that bind and activate the G protein-coupled GnRH receptor expressed by gonadotropes. Hormone secretion and synthesis of gonadotropins are influenced by the amplitude and frequency of GnRH stim...
5 CitationsSource
#1Tomohiro Terasaka (UCSD: University of California, San Diego)H-Index: 10
#2Taeshin Kim (UCSD: University of California, San Diego)H-Index: 7
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 9 authors...
: Gonadotropin secretion, which is elicited by GnRH stimulation of the anterior pituitary gonadotropes, is a critical feature of reproductive control and the maintenance of fertility. In addition, activation of the GnRH receptor (GnRHR) regulates transcription and translation of multiple factors that regulate the signaling response and synthesis of gonadotropins. GnRH stimulation results in a broad redistribution of mRNA between active and inactive polyribosomes within the cell, but the mechanis...
6 CitationsSource
#1Tomohiro Terasaka (UCSD: University of California, San Diego)H-Index: 10
#2Mary E. Adakama (UCSD: University of California, San Diego)H-Index: 1
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 7 authors...
Biological rhythms lie at the center of regulatory schemes that control many aspects of living systems. At the cellular level, meaningful responses to external stimuli depend on propagation and quenching of a signal to maintain vigilance for subsequent stimulation or changes that serve to shape and modulate the response. The hypothalamus-pituitary-gonad endocrine axis that controls reproductive development and function relies on control through rhythmic stimulation. Central to this axis is the p...
8 CitationsSource
#1Sun-Ji Park (KNU: Kyungpook National University)H-Index: 16
#2Jung-Hak Kim (KNU: Kyungpook National University)H-Index: 10
Last. Dong-Seok Lee (KNU: Kyungpook National University)H-Index: 41
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Luteal regression is a natural and necessary event to regulate the reproductive process in all mammals. Prostaglandin F2α (PGF2α) is the main factor that causes functional and structural regression of the corpus luteum (CL). It is well known that PGF2α-mediated ROS generation is closely involved in luteal regression. Peroxiredoxin 2 (Prx2) as an antioxidant enzyme plays a protective role against oxidative stress-induced cell death. However, the effect of Prx2 on PGF2α-induced luteal regression h...
5 CitationsSource
#1Jung-Hak Kim (KNU: Kyungpook National University)H-Index: 10
#2Sun-Ji Park (KNU: Kyungpook National University)H-Index: 16
Last. Dong-Seok Lee (KNU: Kyungpook National University)H-Index: 41
view all 5 authors...
Abstract Aims Leydig cells are characterized by their ability to produce testosterone. When the Leydig cells are unable to produce enough testosterone, spermatogenesis fails completely. Considering this, it is of great interest to investigate whether the expressions of steroidogenic enzymes are affected by testicular heat stress. This study aimed to demonstrate that heat induced ER-stress significantly influences steroidogenic enzyme expression and testosterone production in the Leydig cells. Ma...
30 CitationsSource
#1Sun-Ji Park (KNU: Kyungpook National University)H-Index: 16
#2Taeshin KimH-Index: 7
Last. Dong-Seok Lee (KNU: Kyungpook National University)H-Index: 41
view all 6 authors...
Superovulation induced by exogenous gonadotropin treatment (PMSG/hCG) increases the number of available oocytes in humans and animals. However, Superovulatory PMSG/hCG treatment is known to affect maternal environment, and these effects may result from PMSG/hCG treatment-induced oxidative stress. 2-Cys peroxiredoxins (2-Cys Prxs) act as antioxidant enzymes that protect cells from oxidative stress induced by various exogenous stimuli. Therefore, the objective of this study was to test the hypothe...
10 CitationsSource
#1Taeshin Kim (UCSD: University of California, San Diego)H-Index: 7
#2Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
The appropriate control of synthesis and secretion of the gonadotropin hormones LH and FSH by pituitary gonadotropes is essential for the regulation of reproduction. The hypothalamic neuropeptide GnRH is the central regulator of both processes, coordinating secretion with transcription and translation of the gonadotropin hormone subunit genes. The MAPK family of second messengers is strongly induced in gonadotropes upon GnRH stimulation, and multiple pathways activate these kinases. Intracellula...
12 CitationsSource
#1Sun-Ji ParkH-Index: 16
#2Taeshin KimH-Index: 7
Last. Dong-Seok Lee (KNU: Kyungpook National University)H-Index: 41
view all 3 authors...
Department of Reproductive Medicine, University of California, San Diego, 9500 Gilman Drives, La Jolla, California 92093, USAReceived July 17, 2014/Revised August 11, 2014/Accepted August 11, 2014This study analyzed whether human chorionic gonadotropin (hCG) induces ER stress via the IRE/XBP1 pathway in mouse Leydig tumor (mLTC-1) cells. In a previous study, we demonstrated that the unfolding protein response (UPR) plays an important role in the expression of steroidogenic enzymes by modulating ...
Source
#1Taeshin Kim (UCSD: University of California, San Diego)H-Index: 7
#2Minh-Ha Do (UCSD: University of California, San Diego)H-Index: 6
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 3 authors...
The study of gene expression in gonadotropes has largely focused on the variety of mechanisms regulating transcription of the gonadotropin genes and ancillary factors that contribute to the overall phenotype and function of these cells in reproduction. However, there are aspects of the response to GNRH signaling that are not readily explained by changes at the level of transcription. As our understanding of regulation at the level of mRNA translation has increased, it has become evident that GNR...
16 CitationsSource
#1Minh-Ha Do (UCSD: University of California, San Diego)H-Index: 6
#2Taeshin Kim (UCSD: University of California, San Diego)H-Index: 7
Last. Mark A. Lawson (UCSD: University of California, San Diego)H-Index: 25
view all 8 authors...
The neuropeptide gonadotropin-releasing hormone stimulates synthesis and secretion of the glycoprotein gonadotropic hormones and activates the unfolded protein response, which causes a transient reduction of endoplasmic reticulum-associated mRNA translation. Hormone-treated cell extracts were fractionated to resolve mRNA in active polyribosomes from mRNA in inactive complexes. Quantitative real-time PCR and expression array analysis were used to determine hormone-induced redistribution of mRNAs ...
10 CitationsSource