Constanza Martínez
Pontifical Catholic University of Chile
Simulated body fluidInternal medicinePathologyPeriodontologyCellular differentiationCellMatrix (biology)ChemistryPediatricsExtracellular matrixMaterials scienceMesenchymal stem cellImmunologyMyofibroblastGrowth factorGranulation tissueSonic hedgehogInflammationArthritisPeriodontiumMethylglyoxalPlatelet-poor plasmaArthropathyMalaiseTravel medicinePeriodontal ligament stem cellsPlatelet-rich plasmaWound healingFibroblastAngiogenesisHeadachesChikungunyaStem cellPeriodontal diseasePeriodontal tissueCancer researchConnective tissueViability assayDiabetes mellitusBioinformaticsCell growthMedicineFibronectinBiologyPlateletCell biology
26Publications
12H-index
381Citations
Publications 26
Newest
#1Constanza Martínez (UC: Pontifical Catholic University of Chile)H-Index: 12
#2Sergio González (University of Chile)H-Index: 29
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
view all 4 authors...
Background: Plasma-derived fractions have been used as an autologous source of growth factors; however, limited knowledge concerning their biologic effects has hampered their clinical application. In this study, the authors analyze the content and specific effect of both platelet-rich plasma (PRP) and platelet-poor plasma (PPP) on osteoblastic differentiation using primary cultures of human periodontal ligament stem cells (HPLSCs).Methods: The authors evaluated the growth factor content of PRP a...
18 CitationsSource
#1Constanza Martínez (UC: Pontifical Catholic University of Chile)H-Index: 12
#2Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
Last. Verónica A. Palma Alvarado (University of Chile)H-Index: 1
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Platelet degranulation allows the release of a large amount of soluble mediators, is an essential step for wound healing initiation, and stimulates clotting and angiogenesis. The latter process is one of the most critical biological events observed during tissue repair, increasing the growth of blood vessels in the maturing wound. Angiogenesis requires the action of a variety of growth factors that act in an appropriate physiological ratio to assure functional blood vessel restoration. Platelets...
92 CitationsSource
#1A. Romero (UC: Pontifical Catholic University of Chile)H-Index: 2
#2Mónica Cáceres (UC: Pontifical Catholic University of Chile)H-Index: 16
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
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Background Granulation tissue remodeling and myofibroblastic differentiation are critically important events during wound healing. Tobacco smoking has a detrimental effect in gingival tissue repair. However, studies evaluating the effects of cigarette smoke on these events are lacking. Material and Methods We used gingival fibroblasts cultured within free-floating and restrained collagen gels to simulate the initial and final steps of the granulation tissue phase during tissue repair. Collagen g...
8 CitationsSource
#1Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
#2Mónica Cáceres (University of Chile)H-Index: 16
Last. Jorge Martínez (University of Chile)H-Index: 27
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Gingival wound healing comprises a series of sequential responses that allow the closure of breaches in the masticatory mucosa. This process is of critical importance to prevent the invasion of microbes or other agents into tissues, avoiding the establishment of a chronic infection. Wound healing may also play an important role during cell and tissue reaction to long-term injury, as it may occur during inflammatory responses and cancer. Recent experimental data have shown that gingival wound hea...
29 CitationsSource
#1Patricio C. SmithH-Index: 22
#2Constanza MartínezH-Index: 12
Last. Jorge MartínezH-Index: 27
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Growth factors play critical roles in periodontal repair through the regulation of cell behavior. Many of the cell responses regulated by these proteins include cell adhesion, migration, proliferation and differentiation. Periodontal regeneration involves an organized response of different cells, tissues and growth factors implicated in the coordination of these events. However, periodontal tissue reconstruction is an extremely difficult task. Multiple studies have been performed to understand t...
17 CitationsSource
#1Débora Inzunza (University of Chile)H-Index: 1
#2Cristian Covarrubias (University of Chile)H-Index: 15
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
view all 13 authors...
Nanostructured porous silica coatings were synthesized on titanium by the combined sol–gel and evaporation-induced self-assembly process. The silica-coating structures were characterized by X-ray diffraction, transmission electron microscopy, scanning electron microscopy, and nitrogen sorptometry. The effect of the nanoporous surface on apatite formation in simulated body fluid, protein adsorption, osteoblast cell adhesion behavior, and osteogenic differentiation of human bone marrow mesenchymal...
34 CitationsSource
#1Marcela González (UC: Pontifical Catholic University of Chile)H-Index: 8
#2Carmen Sandoval (UC: Pontifical Catholic University of Chile)H-Index: 3
Last. Katia Abarca (UC: Pontifical Catholic University of Chile)H-Index: 20
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Introduction: There is not known if a viraemia post-oral polio vaccine (OPV) is detectable by modern molecular techniques. Such viraemia could affect the performance of the real time-polymerase chain reaction (PCR) for non polio enterovirus (EV) detection, technique of growing clinical use for the study of febrile infants. Objective: To determine viraemia post-first dose of OPV in healthy infants, by molecular techniques. Patients and Methods: 50 infants less than three months without previous V...
Source
#1Constanza Martínez (University of Chile)H-Index: 12
#2Víctor Hugo Cornejo (University of Chile)H-Index: 10
Last. Verónica Palma (University of Chile)H-Index: 21
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The Sonic Hedgehog (Shh) pathway is responsible for critical patterning events early in development and for regulating the delicate balance between proliferation and differentiation in the developing and adult vertebrate brain. Currently, our knowledge of the potential role of Shh in regulating neural stem cells (NSC) is largely derived from analyses of the mammalian forebrain, but for dorsal midbrain development it is mostly unknown. For a detailed understanding of the role of Shh pathway for m...
14 CitationsSource
#1D. Silva (UC: Pontifical Catholic University of Chile)H-Index: 8
#2Mónica Cáceres (UC: Pontifical Catholic University of Chile)H-Index: 16
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
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Silva D, Caceres M, Arancibia R, Martinez C, Martinez J, Smith P. Effects of cigarette smoke and nicotine on cell viability, migration and myofibroblastic differentiation. J Periodont Res 2012; 47: 599–607. © 2012 John Wiley & Sons A/S Background and Objective: Several studies have analysed the role of nicotine as a prominent agent affecting wound repair in smokers. However, tobacco smoke contains several components that may alter gingival wound healing. The present study aimed to analyse the ro...
33 CitationsSource
#1Mónica Cáceres (UC: Pontifical Catholic University of Chile)H-Index: 16
#2Constanza Martínez (UC: Pontifical Catholic University of Chile)H-Index: 12
Last. Patricio C. Smith (UC: Pontifical Catholic University of Chile)H-Index: 22
view all 4 authors...
Objectives Although platelet-rich plasma (PRP) has been proposed as a therapeutic tool to enhance wound repair, the cellular and molecular mechanisms stimulated by this agent are still not completely understood. The present study was designed to characterize the effects of PRP and platelet-poor plasma (PPP) supernatants on cell responses involved in gingival tissue repair. Methods We studied the response of human gingival fibroblasts (HGF) to PRP and PPP fractions on: matrix contraction, cell mi...
26 CitationsSource