A Cossu
University of Sassari
GeneEndothelial stem cellInternal medicineDownregulation and upregulationPathologyOncologyChemistryOxidative stressMelanomaAntioxidantVascular smooth muscleCell damageMitochondrionProgrammed cell deathReactive oxygen speciesCancer researchBiochemistryRedoxOxidative phosphorylationMedicineIntracellularBiologyCell biology
51Publications
14H-index
459Citations
Publications 52
Newest
#1Roberta Giordo (University of Medicine and Health Sciences)
#1Roberta GiordoH-Index: 13
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
view all 7 authors...
Endothelial cell injury is an early event in systemic sclerosis (SSc) pathogenesis and several studies indicate oxidative stress as the trigger of SSc-associated vasculopathy. Here, we show that circulating factors present in sera of SSc patients increased reactive oxygen species (ROS) production and collagen synthesis in human pulmonary microvascular endothelial cells (HPMECs). In addition, the possibility that iloprost, a drug commonly used in SSc therapy, might modulate the above-mentioned bi...
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#1Anna Maria PosadinoH-Index: 19
#2A CossuH-Index: 14
Last. Gianfranco PintusH-Index: 32
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This work aims to analyze the chemical and biological evaluation of two extracts obtained by olive mill wastewater (OMW), an olive oil processing byproduct. The exploitation of OMW is becoming an important aspect of development of the sustainable olive oil industry. Here we chemically and biologically evaluated one liquid (L) and one solid (S) extract obtained by liquid-liquid extraction followed by acidic hydrolysis (LLAC). Chemical characterization of the two extracts indicated that S has high...
1 CitationsSource
#1Anna Maria Posadino (University of Sassari)H-Index: 19
#2Roberta Giordo (Qatar University)H-Index: 13
Last. Gianfranco Pintus (Qatar University)H-Index: 32
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Background: Dietary intake of natural antioxidants is thought to impart protection against oxidative-associated cardiovascular diseases. Despite many in vivo studies and clinical trials, this issue has not been conclusively resolved. Resveratrol (RES) is one of the most extensively studied dietary polyphenolic antioxidants. Paradoxically, we have previously demonstrated that high RES concentrations exert a pro-oxidant effect eventually elevating ROS levels leading to cell death. Here, we further...
22 CitationsSource
#1Alessandro G. Fois (University of Sassari)H-Index: 17
#2Anna Maria Posadino (University of Sassari)H-Index: 19
Last. Gianfranco Pintus (Qatar University)H-Index: 32
view all 10 authors...
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by an exacerbated fibrotic response. Although molecular and cellular determinants involved in the onset and progression of this devastating disease are largely unknown, an aberrant remodeling of the pulmonary vasculature appears to have implications in IPF pathogenesis. Here, we demonstrated for the first time that an increase of reactive oxygen species (ROS) generation induced by sera from IPF patients drives both colla...
18 CitationsSource
#1Anna Maria Posadino (University of Sassari)H-Index: 19
#2Grazia BiosaH-Index: 13
Last. Gianfranco PintusH-Index: 32
view all 11 authors...
The aim of this work is the evaluation of a green extraction technology to exploit winery waste byproducts. Specifically, a solid–liquid extraction technology (Naviglio Extractor®) was used to obtain polyphenolic antioxidants from the Cagnulari grape marc. The extract was then chemically characterized by spectrophotometric analysis, high-performance liquid chromatography, and mass spectrometry, revealing a total polyphenol content of 4.00 g/L ± 0.05, and the presence of anthocyanins, one of the ...
15 CitationsSource
#1Anna Maria Posadino (University of Sassari)H-Index: 19
#2Hoa Thi Phu (University of Sassari)H-Index: 2
Last. Gianfranco Pintus (College of Health Sciences, Bahrain)H-Index: 32
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Abstract Green tea consumption has been shown to possess cancer chemopreventive activity. Polyphenol E (PE) is a widely used standardized green tea extract formulation. This study was designed to investigate the impact of PE on prostate cancer cells (PC3), analyze the potential signals involved and elucidate whether anti- or pro-oxidant effects may be implicated. Treatment of PC3 cells with 30 and 100 μg/ml PE significantly decreased cell viability and proliferation. At the tested concentrations...
16 CitationsSource
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Salvatore Sotgia (University of Sassari)H-Index: 25
Last. Ciriaco Carru (University of Sassari)H-Index: 38
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Purpose The dietary flavonoids epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG) and epigallocatechin gallate (EGCG) have been shown to interact with circulating albumin for transport in blood to different body tissues. This interaction may modulate their bioavailability and effectiveness.
4 CitationsSource
#1Maria ColombinoH-Index: 19
#2Panagiotis Paliogiannis (University of Sassari)H-Index: 19
Last. Giovannella PalmieriH-Index: 25
view all 21 authors...
Source
#1Grazia PalombaH-Index: 14
#2A Cossu (University of Sassari)H-Index: 14
Last. Giovannella PalmieriH-Index: 25
view all 20 authors...
Source
#1Angelo Zinellu (University of Sassari)H-Index: 31
#2Salvatore Sotgia (University of Sassari)H-Index: 25
Last. Gianfranco Pintus (University of Sassari)H-Index: 32
view all 9 authors...
Epicatechin (EC), epigallocatechin (EGC), epicatechingallate (ECG) and epigallocatechingallate (EGCG) are antioxidants present in the green tea, a widely used beverage whose health benefits are largely recognized. Nevertheless, major physicochemical limitations, such as the high instability of catechins, pose important questions concerning their potential pharmacological use. Recent studies indicate that binding of catechins with plasmatic proteins may modulate their plasma concentration, tissue...
17 CitationsSource