Cristina Borzi
University of Milan
CancerInternal medicineCXCR4OncologymicroRNACell typeMicrovesiclesTumor microenvironmentMdm2Lung cancerLung cancer screeningPTENLungMetastasisLiquid biopsyMutational statusTargeted ngsEpigeneticsReal-time polymerase chain reactionDigital polymerase chain reactionCancer researchCarcinogenesisBioinformaticsComputational biologyText miningMedicineProtein kinase BParacrine signallingFunctional testingIn situ hybridizationBiologyCancer cell
19Publications
8H-index
167Citations
Publications 20
Newest
#1Cristina BorziH-Index: 8
#2Elisa Caiola (Mario Negri Institute for Pharmacological Research)H-Index: 12
Last. Massimo MoroH-Index: 17
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#1Daniela Di Paolo (Istituto Giannina Gaslini)H-Index: 22
Last. Cristina BorziH-Index: 8
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Lung cancer is the leading cause of cancer-related death worldwide. Late diagnosis and metastatic dissemination contribute to its low survival rate. Since microRNA (miRNA) deregulation triggers lung carcinogenesis, miRNAs might represent an interesting therapeutic tool for lung cancer management. We identified seven miRNAs, including miR-126-3p and miR-221-3p, that are deregulated in tumours compared with normal tissues in a series of 38 non-small-cell lung cancer patients. A negative correlatio...
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#1Cristina BorziH-Index: 8
#2Monica GanzinelliH-Index: 21
Last. Massimo MoroH-Index: 17
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Abstract Introduction Preclinical models recently unveiled vulnerability of LKB1/KRAS co-mutated non-small cell lung cancer (NSCLC) to metabolic stress-based treatments. Since miR-17 is a potential epigenetic regulator of LKB1, we hypothesized that wild type LKB1 NSCLC with high miR-17 expression may be sensitive to energetic stress condition, and eligible for metabolic frailties-based therapeutic intervention. Methods We took advantage of NSCLC cell lines with different combinations of KRAS mut...
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#1Cristina BorziH-Index: 8
#2Giulia Galli (University of Milan)H-Index: 10
Last. Massimo MoroH-Index: 17
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LKB1 is frequently mutated in non-small cell lung cancer (NSCLC). LKB1-mutated NSCLCs often have a dismal prognosis and receive lower benefit from the currently available therapies. LKB1 acts as a cell emergency brake in low-energy conditions, by modulating the activity of crucial anabolic enzymes. Thus, loss of LKB1 activity leads to the enhancement of tumor cell proliferation also under conditions of energy shortage. This unrestrained growth may be exploited as an Achilles heel in NSCLC, i.e.,...
2 CitationsSource
#1Cristina BorziH-Index: 8
#2Linda CalzolariH-Index: 2
Last. Orazio FortunatoH-Index: 11
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Lung cancer causes approximately one fifth of all cancer deaths. Tumour cells actively communicate with the surrounding microenvironment to support malignant progression. Extracellular vesicles (EVs) play a pivotal role in intercellular communication and modulate recipient cells by delivering their contents, including proteins and nucleic acids such as microRNAs (miRNAs). We isolated EVs from the conditioned medium (CM) of human lung cancer cell lines and plasma of lung cancer patients and cance...
17 CitationsSource
#1Massimo MoroH-Index: 17
#2Daniela Di Paolo (Istituto Giannina Gaslini)H-Index: 22
Last. Orazio FortunatoH-Index: 11
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Abstract Lung cancer is the leading cause of cancer-related deaths. Late diagnosis and inadequate therapies contribute to poor outcomes. MicroRNAs (miRNAs) are small non-coding RNAs and are involved in lung cancer development. Because miRNAs simultaneously regulate several cancer-related genes, they represent an interesting therapeutic approach for cancer treatment. We have developed Coated Cationic Lipid-nanoparticles entrapping miR-660 (CCL660) and intraperitoneally administered (1.5 mg/Kg) tw...
17 CitationsSource
#1Orazio FortunatoH-Index: 11
#2Cristina BorziH-Index: 8
Last. Gabriella SozziH-Index: 71
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: miRNAs play a central role in the complex signaling network of cancer cells with the tumor microenvironment. Little is known on the origin of circulating miRNAs and their relationship with the tumor microenvironment in lung cancer. Here, we focused on the cellular source and relative contribution of different cell types to circulating miRNAs composing our risk classifier of lung cancer using in vitro/in vivo models and clinical samples. A cell-type specific expression pattern and topography of...
27 CitationsSource
#1Orazio FortunatoH-Index: 11
#2Cristina BorziH-Index: 8
Last. Gabriella SozziH-Index: 71
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INTRODUCTION miRNAs play a role in the complex network of signaling between cancer cells and tumor microenvironment. We previously reported the identification of diagnostic miRNA signatures (MSC) based on 24-miRNAs in plasma samples of lung cancer patients detected by low dose computed tomography (LDCT) screening. MATERIAL and METHODS To evaluate the potential origin of the miRNAs of the diagnostic signature, we analyzed their expression by real-time or digital PCR in both cells and conditioned ...
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#1Massimo MoroH-Index: 17
#2Giulia BertoliniH-Index: 13
Last. Ugo PastorinoH-Index: 70
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1 CitationsSource