Yinu Wang
Northwestern University
CancerDNA damageCellular differentiationChemistryDNA methylationImmunologyTumor microenvironmentChemosensitizerCisplatinTumor initiationTumor progressionALDH1A1Ovarian tumorOvarian cancerHOTAIRStem cellHOX Transcript Antisense RNAEpigeneticsEZH2Cancer researchCancer stem cellLong non-coding RNARNAMedicineBiologyCancer cell
25Publications
8H-index
352Citations
Publications 22
Newest
#1Nkechiyere G. Nwani (NU: Northwestern University)H-Index: 4
#2Salvatore Condello (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 18
Last. Daniela Matei (NU: Northwestern University)H-Index: 59
view all 7 authors...
A small of population of slow cycling and chemo-resistant cells referred to as cancer stem cells (CSC) have been implicated in cancer recurrence. There is emerging interest in developing targeted therapeutics to eradicate CSCs. Aldehyde-dehydrogenase (ALDH) activity was shown to be a functional marker of CSCs in ovarian cancer (OC). ALDH activity is increased in cells grown as spheres versus monolayer cultures under differentiating conditions and in OC cells after treatment with platinum. Here, ...
18 CitationsSource
#1Yinu Wang (IU: Indiana University)H-Index: 8
#2Xingyue Zong (IU: Indiana University)H-Index: 5
Last. Kenneth P. Nephew (IU: Indiana University)H-Index: 70
view all 6 authors...
: In high-grade serous ovarian cancer (OC), chemotherapy eliminates the majority of tumor cells, leaving behind residual tumors enriched in OC stem cells (OCSC). OCSC, defined as aldehyde dehydrogenase-positive (ALDH+), persist and contribute to tumor relapse. Inflammatory cytokine IL-6 is elevated in residual tumors after platinum treatment, and we hypothesized that IL-6 plays a critical role in platinum-induced OCSC enrichment. We demonstrate that IL-6 regulates stemness features of OCSC drive...
50 CitationsSource
#1Ali R. Özeş (IU: Indiana University)H-Index: 8
#2Yinu Wang (IU: Indiana University)H-Index: 8
Last. Kenneth P. Nephew (IU: Indiana University)H-Index: 70
view all 4 authors...
PURPOSE: Most women diagnosed with advanced-stage ovarian cancer develop chemo-resistant tumor recurrence, which is uniformly fatal. Long non-coding RNAs (lncRNAs) play key roles in human diseases, including cancer. Functional studies of the lncRNA HOTAIR (HOX transcript antisense RNA) provide compelling evidence for therapeutic targeting of HOTAIR in ovarian cancer to impact chemoresistance, but targeting lncRNAs in vivo has proven to be difficult. EXPERIMENTAL DESIGN: In the current study, we ...
Source
#1Ali R. ÖzeşH-Index: 8
#2Yinu Wang (IU: Indiana University)H-Index: 8
Last. Kenneth P. NephewH-Index: 70
view all 6 authors...
Long non-coding RNAs (lncRNAs) play key roles in human diseases, including cancer. Functional studies of the lncRNA HOTAIR (HOX transcript antisense RNA) provide compelling evidence for therapeutic targeting of HOTAIR in cancer, but targeting lncRNAs in vivo has proven to be difficult. In the current study, we describe a peptide nucleic acids (PNA)-based approach to block the ability of HOTAIR to interact with EZH2 and subsequently inhibit HOTAIR-EZH2 activity and resensitize resistant ovarian t...
74 CitationsSource
#1Yinu Wang (IU: Indiana University)H-Index: 8
#2Anirban K. Mitra (IU: Indiana University)H-Index: 18
Last. Kenneth P. Nephew (IU: Indiana University Bloomington)H-Index: 70
view all 3 authors...
Purpose: While chemotherapy may succeed initially at decreasing the number of ovarian cancer (OC) cells, it leaves behind tumors enriched in ovarian cancer stem cells (OCSCs), which most likely drive chemoresistance and tumor relapse. An emerging model indicates that non-OCSCs may dedifferentiate and acquire stem cell properties under certain circumstances. Recent studies in OC implicate a critical role for aberrant cytokine interleukin-6 (IL-6) secretion and the IL-6 signaling pathway may play ...
1 CitationsSource
#1Yinu Wang (IU: Indiana University)H-Index: 8
#2Horacio Cardenas (IU: Indiana University)H-Index: 18
Last. Kenneth P. NephewH-Index: 70
view all 9 authors...
Abstracts: 10th Biennial Ovarian Cancer Research Symposium; September 8-9, 2014; Seattle, WA In ovarian and other cancers, emerging data indicate that cancer stem cells contribute to chemoresistance and that their persistence alters clinical outcome. As epigenetic regulators play a major role in the control of normal stem cell differentiation, epigenetics may play a critical role in targeting this subpopulation. Epigenetic aberrations, especially DNA methylation, result in silencing of tumor sup...
Source
#1Fang Fang (IU: Indiana University)H-Index: 24
#2Joanne M. Munck (Astex)H-Index: 10
Last. Kenneth P. Nephew (IU: Indiana University)H-Index: 70
view all 16 authors...
Purpose: To investigate SGI-110 as a “chemosensitizer” in ovarian cancer and to assess its effects on tumor suppressor genes (TSG) and chemoresponsiveness-associated genes silenced by DNA methylation in ovarian cancer. Experimental Design: Several ovarian cancer cell lines were used for in vitro and in vivo platinum resensitization studies. Changes in DNA methylation and expression levels of TSG and other cancer-related genes in response to SGI-110 were measured by pyrosequencing and RT-PCR. Res...
69 CitationsSource
#1Yinu Wang (IU: Indiana University)H-Index: 8
#2Horacio Cardenas (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 18
Last. Daniela Matei (IUPUI: Indiana University – Purdue University Indianapolis)H-Index: 59
view all 9 authors...
Ovarian cancer stem cells (OCSCs) are associated with drug resistance and tumor relapse. Epigenetic aberrations, especially DNA methylation, result in silencing of tumor suppressor and differentiation-associated genes and regulate OCSCs9 survival. To test the hypothesis that DNA hypomethylating agents can “reset” OCSCs towards differentiation, we investigated the effect of the DNA methytransferase inhibitor SGI-110 on OCSCs, defined by aldehyde dehydrogenase 1 (ALDH)(+) cells. We treated ALDH(+)...
Source
#1Yinu Wang (IU: Indiana University)H-Index: 8
#2Horacio Cardenas (IU: Indiana University)H-Index: 18
Last. Daniela MateiH-Index: 59
view all 9 authors...
Emerging results indicate that cancer stem-like cells contribute to chemoresistance and poor clinical outcomes in many cancers, including ovarian cancer (OC). As epigenetic regulators play a major role in the control of normal stem cell differentiation, epigenetics may offer a useful arena to develop strategies to target cancer stem-like cells. Epigenetic aberrations, especially DNA methylation, silence tumor suppressor and differentiation-associated genes that regulate the survival of ovarian c...
96 CitationsSource
#1Fang Fang (IU: Indiana University)H-Index: 24
#2Qingyao ZuoH-Index: 1
Last. Kenneth P. Nephew (IU: Indiana University)H-Index: 70
view all 9 authors...
// Fang Fang 1 , Qingyao Zuo 2 , Jay Pilrose 1 , Yinu Wang 1 , Changyu Shen 3,4 , Meng Li 5 , Phillip Wulfridge 1 , Daniela Matei 6,7,8,9 , Kenneth P. Nephew 1,6,8,10 1 Medical Sciences, Indiana University School of Medicine, Bloomington, IN, USA 2 Department of Endocrinology, Beijing Jishuitan Hospital, Beijing, P.R. China 3 Department of Biostatistics, Indiana University, Indianapolis, IN, USA 4 Computational Biology & Bioinformatics, Indiana University, Indianapolis, IN, USA 5 Norris Medical ...
33 CitationsSource