Soyoung Hong
Asan Medical Center
Self-healing hydrogelsEndothelial stem cellEngineeringBiomedical engineeringMolecular biologyRegeneration (biology)NanotechnologyChemistryIn vivoMatrigelCorneal epitheliumTransplantationMembraneSimulationTissue engineeringMicropumpControl theoryCell cultureCell biologyCancer cell
23Publications
9H-index
261Citations
Publications 22
Newest
#1Hun Lee (UOU: University of Ulsan)H-Index: 1
#1Hun Lee (UOU: University of Ulsan)H-Index: 15
Last. Hungwon Tchah (UOU: University of Ulsan)H-Index: 17
view all 9 authors...
This study aimed to evaluate the efficacy and safety of transplantation with human corneal limbal epithelial (HCLE) cell sheets cultured on carboxymethyl cellulose (CMC)-dopamine (DA)-coated substrates and harvested via enzymatic digestion of CMC with cellulase in a rabbit animal model of limbal stem cell deficiency (LSCD). Synthesized CMC-DA was pretreated onto the surface of culture plates. Then, HCLE cells were cultured on precoated CMC-DA and HCLE cell sheets were harvested using cellulase-c...
Source
#1Sang Woo Lee (Asan Medical Center)H-Index: 12
#2Soyoung Hong (Asan Medical Center)H-Index: 9
Last. Changmo Hwang (UOU: University of Ulsan)H-Index: 5
view all 8 authors...
: The purpose of this study was to demonstrate self-organizing in vitro multicellular tumor spheroid (MCTS) formation in a microfluidic system and to observe the behavior of MCTSs under controlled microenvironment. The employed microfluidic system was designed for simple and effective formation of MCTSs by generating nutrient and oxygen gradients. The MCTSs were composed of cancer cells, vascular endothelial cells, and type I collagen matrix to mimic the in vivo tumor microenvironment (TME). Cel...
10 CitationsSource
#1Soyoung Hong (Asan Medical Center)H-Index: 9
#2Ji Seon Kim (Asan Medical Center)H-Index: 4
Last. Chang Mo Hwang (UOU: University of Ulsan)H-Index: 19
view all 5 authors...
Herein, three-dimensional (3D) bioprinting of engineered constructs with cell-laden biomaterials was investigated for the development of 3D tissue constructs in vitro. The present article proposes a simple coaxial-nozzle-based printing method using a one-step gelling gelatin bioink containing different cell types for vascular structure generation. First, a gelatin bioink prepolymer with a tyramine functional group was synthesized. To facilitate rapid gelation, polyethylene glycol (PEG) was intro...
14 CitationsSource
#1Soyoung Hong (Asan Medical Center)H-Index: 9
#2Eun Young Kang (Asan Medical Center)H-Index: 1
Last. Chang Mo Hwang (UOU: University of Ulsan)H-Index: 19
view all 5 authors...
The vascularization of three-dimensional (3D) tissue constructs is necessary for transporting nutrients and oxygen to the component cells. In this study, a vacuum forming method was applied to emboss a vascular pattern on an electrospun membrane so that guided vascular structures could develop within the construct. Two- or six-layer constructs of electrospun membranes seeded with endothelial cells and pericytes were stacked and subcutaneously implanted into mice. Blood vessel formation in the im...
5 CitationsSource
#1Soyoung Hong (Asan Medical Center)H-Index: 9
#2Jeong Hey Sunwoo (UOU: University of Ulsan)H-Index: 1
Last. Changmo Hwang (UOU: University of Ulsan)H-Index: 5
view all 5 authors...
In this study, we investigated the feasibility of enzymatic digestion of polysaccharides for cell sheet harvesting. Cellulose was digested using cellulase; in brief, cellulose was pre-coated under a confluent cell layer, and then enzymatic digestion of cellulose under the confluent cell layer enabled cell detachment with minimal cell damage, yielding cell sheets. For the surface adhesion of the cellulose, carboxymethyl cellulose (CMC) molecules were conjugated with dopamine (DA), and the synthes...
8 CitationsSource
#1Soyoung Hong (Asan Medical Center)H-Index: 9
#2Je Hwan Yun (UOU: University of Ulsan)H-Index: 1
Last. Changmo Hwang (UOU: University of Ulsan)H-Index: 5
view all 6 authors...
Purpose: We determine the feasibility of human conjunctival epithelial cells (hCjECs) on poly(lactic-co-glycolic) acid (PLGA) membranes for corneal epithelium regeneration. hCjECs on PLGA or polyester (PET) membranes with or without coculture of human Tenon's fibroblasts (hTFs) were compared in vitro, and to determine whether epithelial sheets grown on PLGA membranes can repair injured rabbit corneal epithelium by transplantation for 2 weeks in vivo. Methods: Primary hCjECs were cultured on PLGA...
4 CitationsSource
#1Boyoung Jung (UOU: University of Ulsan)H-Index: 4
#2Soyoung Hong (Asan Medical Center)H-Index: 9
Last. Chang Mo Hwang (UOU: University of Ulsan)H-Index: 19
view all 4 authors...
In this study, for better understanding of patient-derived xenograft (PDX) generation, angiogenic characteristics during PDX cancerous tissue generation was investigated with different initial cell seeding conditions in the hydrogel. We monitored the angiogenic changes during the formation of in vivo cancer cell line xenografts induced by endothelial cells. Our in vivo cancer tissue formation system was designed with the assistance of tissue engineering technology to mimic patient-derived xenogr...
4 CitationsSource
#1Soyoung Hong (Asan Medical Center)H-Index: 9
#2Boyoung Jung (Asan Medical Center)H-Index: 4
Last. Chang Mo Hwang (UOU: University of Ulsan)H-Index: 19
view all 3 authors...
A major hurdle in engineering thick and laminated tissues such as skin is how to vascularize the tissue. This study introduces a promising strategy for generating multi-layering engineered tissue sheets consisting of fibroblasts and endothelial cells co-seeded on highly micro-fibrous, biodegradable polycaprolactone membrane. Analysis of the conditions for induction of the vessels in vivo showed that addition of endothelial cell sheets into the laminated structure increases the number of incorpor...
9 CitationsSource
#1Ji Seon KimH-Index: 4
#2Soyoung HongH-Index: 9
Last. Changmo HwangH-Index: 5
view all 3 authors...
3D printing is also known as additive manufacturing technique in which has been used in various commercial fields such as engineering, art, education, and medicine. The applications such as fabrication of tissues and organs, implants, drug delivery, creation surgical models using 3D printer in medic...
3 CitationsSource
#1Eun-Soon Kim (Asan Medical Center)H-Index: 1
#2Soyoung Hong (Asan Medical Center)H-Index: 9
Last. Hungwon Tchah (Asan Medical Center)H-Index: 12
view all 5 authors...