Shan-Shan Liu
Peking Union Medical College
CytotoxicityPhosphorylationCancerUbiquitin ligaseMolecular biologyHigh-performance liquid chromatographyChemistryApoptosisImmunologyAutophagyUbiquitinDAPIContent determinationTRIB3Epidermal growth factor receptorPhosphatidylserineMTT assayPathogenesisMitochondrionProgrammed cell deathCancer researchFlow cytometryTraditional medicineStereochemistryMedicineCell cultureTranscription factorBiologyCell biology
37Publications
13H-index
412Citations
Publications 36
Newest
#1Ke Li (Peking Union Medical College)H-Index: 14
#2Tingting Zhang (Peking Union Medical College)H-Index: 32
Last. Zhuo-Wei Hu (Peking Union Medical College)H-Index: 29
view all 18 authors...
Most basal-like breast cancers (BLBCs) are triple-negative breast cancers (TNBCs), which have the worst prognosis and distant metastasis-free survival among breast cancer subtypes. Now, no targeted therapies are available for patients with BLBC due to the lack of reliable and effective molecular targets. Here, we performed the BLBC tissue microarray-based immunohistochemical analysis and showed that Faciogenital Dysplasia 5 (FGD5) abundance is associated with poor prognosis in BLBCs. FGD5 deleti...
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#1Ke Li (CSU: Central South University)H-Index: 2
#2Feng Wang (Peking Union Medical College)H-Index: 10
Last. Zhuo-Wei Hu (CSU: Central South University)H-Index: 29
view all 17 authors...
The transcription factor MYC is deregulated in almost all human cancers, especially in aggressive lymphomas, through chromosomal translocation, amplification, and transcription hyperactivation. Here, we report that high expression of tribbles homologue 3 (TRIB3) positively correlates with elevated MYC expression in lymphoma specimens; TRIB3 deletion attenuates the initiation and progression of MYC-driven lymphoma by reducing MYC expression. Mechanistically, TRIB3 interacts with MYC to suppress E...
2 CitationsSource
#1Shan-Shan Liu (SDU: Shandong University)H-Index: 13
#2Jie Qi (SDU: Shandong University)H-Index: 1
Last. Xia Li (SDU: Shandong University)H-Index: 17
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#1Jiao-Jiao Yu (Peking Union Medical College)H-Index: 12
#2Dan-dan Zhou (Peking Union Medical College)H-Index: 3
Last. Zhuo-Wei Hu (Peking Union Medical College)H-Index: 29
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High expression or aberrant activation of epidermal growth factor receptor (EGFR) is related to tumor progression and therapy resistance across cancer types, including non-small cell lung cancer (NSCLC). EGFR tyrosine kinase inhibitors (TKIs) are first-line therapy for NSCLC. However, patients eventually deteriorate after inevitable acquisition of EGFR TKI-resistant mutations, highlighting the need for therapeutics with alternative mechanisms of action. Here, we report that the elevated tribbles...
3 CitationsSource
#1Xiaowei Zhang (Peking Union Medical College)H-Index: 17
#2Ji-Chao Zhou (Peking Union Medical College)H-Index: 6
Last. Zhuo-Wei Hu (Peking Union Medical College)H-Index: 29
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ABSTRACTImpaired macroautophagy/autophagy is involved in the pathogenesis of hepatic fibrosis. However, how aberrant autophagy promotes fibrosis is far from understood. Here, we aimed to define a p...
23 CitationsSource
#1Shuang-Shuang Tian (Henan University)H-Index: 1
Last. Zhi-Min WangH-Index: 13
view all 7 authors...
An ultra-performance liquid chromatography(UPLC) method integrating characteristic chromatogram and eight terpenoids determination has been established for comparing the differences of Alismatis Rhizoma(Zexie) from different product areas. Thirty-seven batches of crude drugs and thirty batches of prepared slices of Alismatis Rhizoma were analyzed. The obtained data were analyzed by similarity evaluation, principal components analysis(PCA) and partial least squares discriminant analysis(PLS-DA). ...
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#1Shan-Shan LiuH-Index: 1
#1Shan-Shan Liu (Peking Union Medical College)H-Index: 13
Last. Lu GaoH-Index: 2
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Alismatis Rhizoma is a traditional Chinese medicine, which was widely used in clinical prescriptions and proprietary Chinese medicine. Over 220 compounds have been isolated from it, including triterpenoids, sesquiterpenoids, diterpenoids, polysaccharides, nitrogen compounds, phenylpropanoids, flavones and sterides. The pharmacological studies show that Alismatis Rhizoma exhibits diuretic, anti-urolithiatic, anti-hyperlipidemia, antidiabetics, antitumor, antioxidative, anti-inflammatory, anti-com...
2 CitationsSource
#1Xiao-Mei Zhao (Shanxi University)
#1Xiao-Mei Zhao (Shanxi University)
Last. Zhi-Min WangH-Index: 13
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The present research was launched to improve the quality standards of Alismatis Rhizoma and supply scientific evidence and recommendations for the quality control of Alismatis Rhizoma in Chinese Pharmacopoeia(Ch. P) 2020 edition. The contents of water, total ash, heavy metals and deleterious element, pesticide residues and alcohol-soluble extract were analyzed according to the methods listed in the volume Ⅳ of Ch. P 2015 edition. Alisol B 23-acetate, alisol C 23-acetate and reference herbs were ...
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#1Shan-Shan LiuH-Index: 1
#1Shan-Shan Liu (Peking Union Medical College)H-Index: 13
Last. Zhi-Min WangH-Index: 13
view all 8 authors...
Alismatis Rhizoma(Zexie) is a commonly used traditional Chinese medicine, and it is separated into "Chuan Zexie"(Sichuan and Hubei provinces), "Jian Zexie"(Fujian and Jiangxi provinces) and "Guang Zexie"(Guangxi province) according to different producing areas. Alisma plantago-aquatica and A. orientale were listed as the original plants of Alismatis Rhizoma in different editions of Chinese Pharmacopoeia(Ch.P), respectively. The botanical origins of Alismatis Rhizoma caused much controversy durin...
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#1Shan-Shan LiuH-Index: 1
#1Shan-Shan Liu (Peking Union Medical College)H-Index: 13
Last. Lu GaoH-Index: 2
view all 8 authors...
Ten compounds, including nucleosides and amino acids were identified by UPLC-Q-TOF-MS. HPLC fingerprints on these compounds in Alismatis Rhizoma were established for the first time. The comparisons of Alismatis Rhizoma from different regions were conducted by the similarity evaluation and hierarchical cluster analysis(HCA). Meanwhile, the HPLC-DAD method for the content determination of five nucleosides was also established. The results showed that the similarities of Alismatis Rhizoma collected...
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