M de Boer
Leiden University
GeneInternal medicineAntigenCD28Molecular biologyCytotoxic T cellCatalysisInorganic chemistryChemistryImmunologyT cellChronic granulomatous diseaseNADPH oxidaseCD40MutationMonoclonal antibodyGeneticsAntigen-presenting cellMedicineBiology
Publications 112
#1A.C. Westgeest (LUMC: Leiden University Medical Center)
#2Emile F. Schippers (LUMC: Leiden University Medical Center)H-Index: 14
Last. Merel M. C. Lambregts (LUMC: Leiden University Medical Center)H-Index: 3
view all 9 authors...
Methicillin-resistant Staphylococcus aureus (MRSA) colonization leads to increased infection rates and mortality. Decolonization treatment has been proven to prevent infection and reduce transmission. As the optimal antimicrobial strategy is yet to be established, different regimens are currently prescribed to patients. This study aimed to evaluate the efficacy of the decolonization treatments recommended by the Dutch guideline. A retrospective multicenter cohort study was conducted in five Dutc...
#1H Scheper (LEI: Leiden University)H-Index: 2
#2L M Gerritsen (LEI: Leiden University)
Last. M de Boer (LEI: Leiden University)H-Index: 31
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The treatment of staphylococcal prosthetic joint infection (PJI) with debridement, antibiotics, and retention of the implant (DAIR) often results in failure. An important evidence gap concerns the treatment with rifampicin for PJI. A systematic review and meta-analysis were conducted to assess the outcome of staphylococcal hip and/or knee PJI after DAIR, focused on the role of rifampicin. Studies published until September 2, 2020 were included. Success rates were stratified for type of joint and...
#1S. J. RottierH-Index: 3
#2L.C. DreuningH-Index: 1
Last. W. H. SchreursH-Index: 3
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AIM Connective tissue changes due to ageing or diseases leading to changes in the colonic wall is one theory for development of diverticula. Alpha-1 antitrypsin(A1AT), a protease inhibitor that protects connective tissue, possibly plays a role in the aetiology of diverticulosis. The aim of this study was to explore associations between the development of diverticula and A1AT deficiency. METHODS A multicentre prospective case-control study. A total of 221 patients aged ≥60 years with acute abdomi...
#1M de Boer (UvA: University of Amsterdam)H-Index: 31
#2Mirjam J. NijdamH-Index: 9
Last. Lucia M. Talamini (UvA: University of Amsterdam)H-Index: 22
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STUDY OBJECTIVES: Sleep problems are a core feature of post-traumatic stress disorder. The aim of this study was to find a robust objective measure for the sleep disturbance in PTSD patients. METHODS: The current study assessed EEG power across a wide frequency range and multiple scalp locations, in matched trauma-exposed individuals with and without PTSD, during rapid eye movement (REM) and non-REM (NREM) sleep. In addition, a full polysomnographical evaluation was performed, including sleep st...
10 CitationsSource
#1Henk Scheper (LEI: Leiden University)H-Index: 3
#2R. Derogee (LEI: Leiden University)H-Index: 1
Last. M de Boer (LEI: Leiden University)H-Index: 31
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Abstract Background Early postoperative discharge after joint arthroplasty may lead to decreased wound monitoring. A mobile woundcare app with an integrated algorithm to detect complications may lead to improved monitoring and earlier treatment of complications. In this study, the ease of use and perceived usefulness of such a mobile app was investigated. Objective Primary objective was to investigate the ease of use and perceived usefulness of using a woundcare app. Secondary objectives were th...
10 CitationsSource
#1Rosalie Lubbers (LUMC: Leiden University Medical Center)H-Index: 5
#2L J J Beaart-van de Voorde (LUMC: Leiden University Medical Center)H-Index: 3
Last. Leendert A. Trouw (LUMC: Leiden University Medical Center)H-Index: 61
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IntroductionC1q is an essential part of the classical pathway of complement activation. Genetic deficiencies, caused by homozygous mutations in one of the C1q genes, are rare and are strongly assoc...
1 CitationsSource
#1S. J. RottierH-Index: 3
#2S. T. van DijkH-Index: 5
Last. M. A. BoermeesterH-Index: 5
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Background: Routine colonoscopy was traditionally recommended after acute diverticulitis to exclude coexistent malignancy. Improved CT imaging may make routine colonoscopy less required over time but most guidelines still recommend it. The aim of this review was to assess the role of colonoscopy in patients with CT-proven acute diverticulitis. Methods: PubMed and Embase were searched for studies reporting the prevalence of advanced colorectal neoplasia (ACN) or colorectal carcinoma in patients w...
15 CitationsSource
#1E.B. Warreman (LEI: Leiden University)H-Index: 1
#2M. Mc Lambregts (LEI: Leiden University)H-Index: 1
Last. M de Boer (LEI: Leiden University)H-Index: 31
view all 7 authors...
Abstract Background Knowledge of determinants that influence antibiotic prescription behaviour (APB) is essential for the successful implementation of antimicrobial stewardship interventions. The theory of planned behaviour (TPB) is an established model that describes how cognitions drive human behaviour. Objectives The objective of this study was to identify the sociocultural and behavioural determinants that affect APB and to construct a TPB framework of behavioural intent. Methods The followi...
21 CitationsSource
#1R.J. van de Peppel (LEI: Leiden University)H-Index: 3
#1R.J. van de Peppel (LEI: Leiden University)H-Index: 1
Last. Jacco Wallinga (LEI: Leiden University)H-Index: 55
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ABSTRACT Objectives Triazole resistance in Aspergillus spp. is emerging and complicates prophylaxis and treatment of invasive aspergillosis (IA) worldwide. New polymerase chain reaction (PCR) tests on broncho-alveolar lavage (BAL) fluid allow for detection of triazole resistance at a genetic level, which has opened up new possibilities for targeted therapy. In the absence of clinical trials, a modelling study delivers estimates of the added value of resistance detection with PCR, and which empir...
3 CitationsSource
#1E. de Jonge (LEI: Leiden University)H-Index: 22
#1E. de Jonge (LEI: Leiden University)H-Index: 7
Last. K.E. Veldkamp (LEI: Leiden University)H-Index: 2
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Summary Background Sink drains in intensive care units (ICUs) are frequently colonized with bacteria such as Pseudomonas aeruginosa. Aim To study the influence of installing disinfecting devices on sink drains on colonization of sinks and patients in an ICU during a prolonged outbreak of multidrug-resistant P. aeruginosa. Methods From 2010, there was a clonal outbreak of multidrug-resistant P. aeruginosa (MDR-PA). In April 2013, in ICU subunit A, the siphons draining these sinks were replaced by...
11 CitationsSource