Kelly M. Leyden
University of California, San Diego
Fluid-attenuated inversion recoveryAnatomyPercentileInternal medicineMagnetic resonance imagingHyperintensityDiffusion MRIPsychologyNeuroscienceCognitionFrontal lobeEpilepsyEpilepsy syndromesUncinate fasciculusTemporal lobeWhite matterNuclear medicineBrain mappingAudiologyNeuroimagingMedicineFractional anisotropy
18Publications
10H-index
374Citations
Publications 13
Newest
#1Kathryn R. Tringale (UCSD: University of California, San Diego)H-Index: 11
#2Tanya T. Nguyen (UCSD: University of California, San Diego)H-Index: 16
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 14 authors...
Abstract Background and purpose Executive function (EF) decline is common after brain radiation therapy (RT), yet the etiology is unclear. We analyzed the association between longitudinal changes in frontal lobe white matter microstructure and decline in EF following RT in brain tumor patients on a prospective clinical trial. Materials and methods Diffusion tensor imaging was obtained on 22 patients with brain tumors prior to RT, as well as 3- and 6-months post-RT, in a prospective, observationa...
15 CitationsSource
#1Katie L. Doyle (UCSD: University of California, San Diego)H-Index: 14
#2Steven Paul Woods (UH: University of Houston)H-Index: 68
Last. Jody Corey-Bloom (UCSD: University of California, San Diego)H-Index: 61
view all 8 authors...
ABSTRACTHIV-associated neurocognitive disorders (HAND) commonly feature verbal episodic memory impairment historically characterized by a retrieval deficit, consistent with a classic “subcortical” presentation; however, there are hints of a subtle shift toward a more “cortical” memory profile characterized by a primary encoding deficit. The current study evaluated this possibility by comparing the pattern of HAND-associated verbal episodic memory deficits to those of traditional “subcortical” (i...
4 CitationsSource
#1Christopher D. Whelan (SC: University of Southern California)H-Index: 23
#2Andre Altmann (UCL: University College London)H-Index: 26
Last. Sanjay M. Sisodiya (UCL Institute of Neurology)H-Index: 89
view all 91 authors...
Progressive functional decline in the epilepsies is largely unexplained. We formed the ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, pooling data from 24 research centres in 14 countries across Europe, North and South America, Asia, and Australia. Structural brain measures were extracted from MRI brain scans across 2149 individuals with epilepsy, divided into four epilepsy subgroups including idiopathic generalized epilepsies (n =367), mesial tempora...
137 CitationsSource
#1Yu-Hsuan A. Chang (UCSD: University of California, San Diego)H-Index: 7
#2Nobuko Kemmotsu (UCSD: University of California, San Diego)H-Index: 9
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 14 authors...
Abstract This study explored the relationships among multimodal imaging, clinical features, and language impairment in patients with left temporal lobe epilepsy (LTLE). Fourteen patients with LTLE and 26 controls underwent structural MRI, functional MRI, diffusion tensor imaging, and neuropsychological language tasks. Laterality indices were calculated for each imaging modality and a principal component (PC) was derived from language measures. Correlations were performed among imaging measures, ...
7 CitationsSource
#1A. KrishnanH-Index: 4
#2Roshan KarunamuniH-Index: 15
Last. Nathan S. WhiteH-Index: 28
view all 16 authors...
BACKGROUND AND PURPOSE: ADC as a marker of tumor cellularity has been promising for evaluating the response to therapy in patients with glioblastoma but does not successfully stratify patients according to outcomes, especially in the upfront setting. Here we investigate whether restriction spectrum imaging, an advanced diffusion imaging model, performed after an operation but before radiation therapy, could improve risk stratification in patients with newly diagnosed glioblastoma relative to ADC...
5 CitationsSource
#1Emily C. Edmonds (UCSD: University of California, San Diego)H-Index: 19
#2Joel Eppig (UCSD: University of California, San Diego)H-Index: 13
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 7 authors...
Objective: We investigated differences in regional cortical thickness between previously identified empirically derived mild cognitive impairment (MCI) subtypes (amnestic MCI, dysnomic MCI, dysexecutive/mixed MCI, and cluster-derived normal) in order to determine whether these cognitive subtypes would show different patterns of cortical atrophy. Methods: Participants were 485 individuals diagnosed with MCI and 178 cognitively normal individuals from the Alzheimer9s Disease Neuroimaging Initiativ...
37 CitationsSource
#1Richard Q. Loi (UCSD: University of California, San Diego)H-Index: 4
#2Kelly M. Leyden (UCSD: University of California, San Diego)H-Index: 10
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 9 authors...
SummaryObjective Diffusion tensor imaging (DTI) has become a popular tool for delineating the location and extent of white matter injury in temporal lobe epilepsy (TLE). However, DTI yields nonspecific measures that are confounded by changes occurring within both the intracellular and extracellular environments. This study investigated whether an advanced diffusion method, restriction spectrum imaging (RSI) could provide a more robust measure of white matter injury in TLE relative to DTI due to ...
9 CitationsSource
#1Carrie R. McDonaldH-Index: 38
#2Rachel L. DelfantiH-Index: 5
Last. Nikdokht FaridH-Index: 17
view all 14 authors...
Diffusion-weighted imaging has shown initial promise for evaluating response to bevacizumab in patients with high-grade glioma (HGG). However, it is well recognized that the apparent diffusion coefficient (ADC) is influenced by bevacizumab-induced reductions in edema, which may limit its prognostic value. We demonstrate that an advanced diffusion-weighted imaging technique, restriction spectrum imaging (RSI), improves the evaluation of response to bevacizumab because unlike ADC, RSI is not affec...
21 CitationsSource
#1S. Balter (UCSF: University of California, San Francisco)H-Index: 1
#2George Lin (Palo Alto University)H-Index: 2
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 5 authors...
Abstract Advanced, noninvasive imaging has revolutionized our understanding of language networks in the brain and is reshaping our approach to the presurgical evaluation of patients with epilepsy. Functional magnetic resonance imaging (fMRI) has had the greatest impact, unveiling the complexity of language organization and reorganization in patients with epilepsy both pre- and postoperatively, while volumetric MRI and diffusion tensor imaging have led to a greater appreciation of structural and ...
15 CitationsSource
Diffusion tensor imaging (DTI) has provided considerable insight into our understanding of epilepsy as a network disorder, revealing subtle alterations in white matter microstructure both proximal and distal to the epileptic focus. These white matter changes have been shown to assist with lateralizing the seizure focus, as well as delineating the location/anatomy of key white matter tracts (i.e., optic radiations) for surgical planning. However, only recently have studies emerged describing the ...
19 CitationsSource