Milena A. Niejedli
Medical University of Lublin
Analytical chemistryExtrapolationHigh-performance liquid chromatographyAqueous solutionChemistryThin-layer chromatographyPartition coefficientLipophilicityCalculation methodsLipinski's rule of fiveChromatography
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#1Anna Hawrył (Medical University of Lublin)H-Index: 6
#2Łukasz Popiołek (Medical University of Lublin)H-Index: 11
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This paper describes the evaluation of the lipophilicity of newly synthesized thiosemicarbazides and their cyclic analogues 1,2,4-triazol-3-thiones obtained using experimental and calculated methods. Previous studies have shown these compounds have antibacterial activity. The chromatographic behavior of analyzed compounds was studied by reversed phase high performance liquid chromatography (RP-HPLC) and reversed phase thin layer chromatography (RP-TLC). The aqueous mobile phases containing metha...
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