Akira Satou
Aichi Medical University
CD5Internal medicinePathologyMucocutaneous zoneCD20ImmunologyImmunohistochemistryVirusBiopsyChemotherapyLymphoproliferative disordersImmunodeficiencyB cellDiffuse large B-cell lymphomaLymphomaPathogenesisPD-L1MethotrexateEpstein–Barr virusCancer researchMedicineBiologyImmune systemGastroenterology
51Publications
8H-index
244Citations
Publications 53
Newest
#1Akira Satou (Aichi Medical University)H-Index: 8
#2Shigeo Nakamura (Nagoya University)H-Index: 101
BACKGROUND Epstein-Barr virus (EBV) is detected in a variety of B-cell lymphomas (BCLs) and B-cell lymphoproliferative disorders (B-LPDs). Immunodeficiency has been considered to play a key role in the pathogenesis of these diseases. In addition, immune escape of tumor cells may also contribute to the development of EBV+ BCLs and B-LPDs. The PD-1/PD-L1 pathway is particularly important for immune escape of tumor cells that contribute to development of lymphoma through suppression of cytotoxic T-...
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#1Yutaro Kondo (Aichi Gakuin University)
#2Susumu Suzuki (Aichi Medical University)H-Index: 12
Last. Akira Satou (Aichi Medical University)H-Index: 8
view all 14 authors...
Immunotherapy with immune-checkpoint therapy has recently been used to treat oral squamous cell carcinomas (OSCCs). However, improvements in current immunotherapy are expected because response rates are limited. Transforming growth factor-β (TGF-β) creates an immunosuppressive tumor microenvironment (TME) by inducing the production of regulatory T-cells (Tregs) and cancer-associated fibroblasts and inhibiting the function of cytotoxic T-lymphocytes (CTLs) and natural killer cells. TGF-β may be a...
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#1Eri Ishikawa (Nagoya University)H-Index: 6
#2Akira Satou (Aichi Medical University)H-Index: 8
Last. Mitsuhiro Fujishiro (Nagoya University)H-Index: 64
view all 5 authors...
Epstein-Barr virus positive B-cell lymphoproliferative disorder (EBV+ B-LPD) encompasses a broad clinicopathological spectrum and distinct clinical behavior that relatively favors the gastrointestinal (GI) tract. In this review, we provide an update on the clinicopathological features and biological behavior of EBV-positive mucocutaneous ulcer (EBVMCU) and primary EBV+ diffuse large B-cell lymphoma (DLBCL) of the GI tract. EBVMCU is a newly recognized entity but well known as an indolent and sel...
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#1Seiji Yamada (Fujita Health University)H-Index: 5
#2Jun Muto (Fujita Health University)H-Index: 7
Last. Shigeo Nakamura (Nagoya University)H-Index: 101
view all 15 authors...
Primary central nervous system lymphomas (PCNSLs) rarely exhibit intratumoral hemorrhage. The differential diagnosis of hemorrhagic neoplasms of the central nervous system (CNS) currently includes metastatic carcinomas, melanomas, choriocarcinomas, oligodendrogliomas, and glioblastomas. Here we present the clinical, radiological, pathological, and molecular genetic features of six cases of PCNSL associated with intratumoral hemorrhage. The median age of patients was 75 years, with male predomina...
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#1Kazuho MorichikaH-Index: 5
#1Kazuho Morichika (RMIT: RMIT University)
Last. Hiroaki MasuzakiH-Index: 64
view all 16 authors...
On the basis of immunohistochemistry, diffuse large B-cell lymphoma (DLBCL) is categorized as a germinal center B-cell (GCB) or non-GCB subtype. Recent integrated genomic analyses have highlighted the importance of the JAK-STAT3 pathway in the molecular pathogenesis of DLBCL. However, its relevance to clinical outcomes remains controversial. Therefore, we evaluated the extent of the nuclear expression of phosphorylated STAT3 (pSTAT3), a surrogate marker of signal transducer and activator of tran...
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#1Yasuki Hori (Nagoya City University)H-Index: 13
#2Suresh T. Chari (Mayo Clinic)H-Index: 103
Last. Akira Satou (Aichi Medical University)H-Index: 8
view all 14 authors...
Biliary strictures caused by inflammation or fibrosis lead to jaundice and cholangitis which often make it difficult to distinguish malignant strictures. In cases when malignancy cannot be excluded, surgery is often performed. The concept of immunoglobulin G4 (IgG4)-related sclerosing cholangitis (SC) as a benign biliary stricture was recently proposed. The high prevalence of the disease in Asian countries has resulted in multiple diagnostic and treatment guidelines; however, there is need to fo...
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#1Takuji Tsuyuki (Aichi Medical University)H-Index: 2
#2Akira SatouH-Index: 8
Last. Toyonori TsuzukiH-Index: 8
view all 5 authors...
Segmental absence of the intestinal musculature (SAIM) can cause intestinal perforation in adults. However, its prevalence and clinicopathologic features have not been well-described. This study aimed to determine the prevalence of SAIM-associated perforation and characterize its clinicopathologic features. We retrospectively examined 109 cases of intestinal perforation that underwent surgical resection from January 2009 to December 2019. SAIM was defined as the complete absence of the musculari...
1 CitationsSource
#1Akira Satou (Aichi Medical University)H-Index: 8
#2Tetsuya Tabata (Okayama University)H-Index: 3
Last. Shigeo Nakamura (Nagoya University)H-Index: 101
view all 11 authors...
Plasma cell differentiation (PCD) is frequently observed in some entities of non-Hodgkin B cell lymphoma, including both low-grade and high-grade lymphomas. However, except for plasmablastic lymphoma and primary effusion lymphoma, EBV+ B cell lymphoproliferative disorder (LPD) with PCD has not been well addressed due to its rarity. We clinicopathologically examined five cases of nodal EBV+ polymorphic B cell LPD with PCD (PBLPD-PCD) initially diagnosed as polymorphic EBV+ diffuse large B cell ly...
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#1Ayako Sakakibara (Nagoya University)H-Index: 8
#2Yuka Suzuki (Nagoya University)H-Index: 8
Last. Seiichi KatoH-Index: 12
view all 12 authors...
Follicular T-cell lymphoma (FTCL), one of the nodal T-cell lymphomas with T follicular helper (TFH) phenotype, is an uncommon disease. The diagnosis of FTCL is challenging on the distinction from the morphological mimics mostly exemplified by follicular lymphoma. Here, we described a case of FTCL that mimicked lymphocyte-rich classic Hodgkin lymphoma (LRCHL). A 47-year-old male presented with cervical lymphadenopathy. The biopsy specimen demonstrated nodular lymphoid proliferation, which include...
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#1Taishi Takahara (Aichi Medical University)H-Index: 8
#2Akira Satou (Aichi Medical University)H-Index: 8
Last. Shigeo Nakamura (Nagoya University)H-Index: 101
view all 11 authors...
The programmed death 1 (PD1)/PD1 ligand (PD-L1) axis plays an important role in the pathogenesis of Epstein-Barr virus-positive diffuse large B cell lymphoma, not otherwise specified (EBV+ DLBCL, NOS). Here, we describe PD-L1 expression by EBV+ DLBCL, NOS in order to evaluate its possible contribution to the pathogenesis of this tumor. The study included 57 cases of EBV+ DLBCL, NOS. The median patient age was 69 years and 95% (n = 54) were aged > 45. Extranodal lesions were present in 39 (69%) a...
3 CitationsSource