Areum Han
Boston Children's Hospital
Induced pluripotent stem cellHaematopoiesismicroRNAEmbryonic stem cellCellular differentiationChemistryAlternative splicingProgenitor cellHumanized mouseHematopoietic stem cellRUNX1Pathogenic bacteriaMyeloidStaphylococcus aureusCord bloodStem cellExonRNA-binding proteinLIN28Cancer researchGeneticsRNA splicingBiologyImmune systemMicrobiologyCell biology
Publications 35
#1A-Ra Jang (CAU: Chung-Ang University)
#2Areum Han (CAU: Chung-Ang University)H-Index: 14
Last. Sun-Young Lee (CAU: Chung-Ang University)H-Index: 19
view all 7 authors...
The risk of foodborne illnesses caused by pathogens could be increased in fresh-cut fruit products owing to contamination during processing. Therefore, this study was conducted to investigate the microbiological quality and safety of commercial fresh-cut fruit products in Korea. Additionally, the growth of Listeria monocytogenes in selected fresh-cut fruits was evaluated, and their growth curves were analyzed using predictive growth modeling. The mean count of total aerobic bacteria, coliforms, ...
#1Soyul Lee (CAU: Chung-Ang University)
#2Areum Han (CAU: Chung-Ang University)H-Index: 14
Last. Sun-Young Lee (CAU: Chung-Ang University)H-Index: 19
view all 8 authors...
Abstract null null Fresh fruit and vegetable juices that have not been pasteurized can cause foodborne diseases. Therefore, microbial quality monitoring of fresh fruit and vegetable juices sold domestically is necessary. Here, 100 fresh fruit and vegetable juices were purchased from online and offline stores in Korea and monitored quantitatively and qualitatively for general microbial quality and foodborne pathogens. Total aerobic bacteria (TAB), coliform, yeast/mold (Y/M), Bacillus cereus, Stap...
#1Jihan K. Osborne (Boston Children's Hospital)H-Index: 12
#2Melissa A. Kinney (Boston Children's Hospital)H-Index: 13
Last. Kaloyan M. Tsanov (Boston Children's Hospital)H-Index: 7
view all 14 authors...
The molecular mechanisms that govern the choreographed timing of organ development remain poorly understood. Our investigation of the role of the Lin28a and Lin28b paralogs during the developmental process of branching morphogenesis establishes that dysregulation of Lin28a/b leads to abnormal branching morphogenesis in the lung and other tissues. Additionally, we find that the Lin28 paralogs, which regulate post-transcriptional processing of both mRNAs and microRNAs (miRNAs), predominantly contr...
#1Soojin Park (Catholic University of Korea)
#2Hee-Je Kim (Catholic University of Korea)H-Index: 25
Last. Areum HanH-Index: 14
view all 4 authors...
Background and objectives null The increased expression for the Fms-related tyrosine kinase-4 (FLT-4, known as VEGFR-3) is relevant to dysfunctional natural killer (NK) cells in acute myeloid leukemia (AML). MAZ51 (M), a VEGFR-3 inhibiting chemical, was effectively restored the function of NK cells via the high expression of interferon- gamma (IFN-γ) in NK cells, as shown in our previous study. Although tremendous amount of clinical data using peptides are currently available in real clinic, pep...
Background and Objectives Human CD34+ hematopoietic stem cells can reconstitute the human hematopoietic system when transplanted into immunocompromised mice after irradiation. Human leukapheresis peripheral blood (LPB)- and cord blood (CB)-derived CD34+ cells have a similar capacity to reconstitute myeloid lineage cells in a humanized mice (hu-mice) model. However, potent stem cells, such as CB-CD34+ cells, efficiently reconstitute the lymphoid system in vivo compared to LPB-CD34+ cells. Modelin...
#1Areum Han (Harvard University)H-Index: 14
#2Alena Yermalovich (Boston Children's Hospital)H-Index: 7
Last. George Q. Daley (Harvard University)H-Index: 128
view all 20 authors...
#1Wade W. Sugden (Harvard University)H-Index: 4
#2Vanessa Lundin (KI: Karolinska Institutet)H-Index: 11
Last. Trista E. North (Boston Children's Hospital)H-Index: 32
view all 12 authors...
Hematopoietic stem cells (HSCs) are born from cells in the dorsal aorta that adopt hematopoietic potential and commitment during development. Physical forces, namely wall shear stress (WSS) and cyclic stretch (CS), produced by hemodynamic blood flow are required to generate HSCs from arterial endothelium, but the mechanisms by which these forces are transduced into a “stemness” regulatory program remain unknown. Using a novel “dorsal-aorta-on-a-chip” microfluidic platform, we demonstrate that ex...
#1Jeoung Eun LeeH-Index: 12
#2Ji Yoon LeeH-Index: 6
Last. Dong Ryul LeeH-Index: 21
view all 15 authors...
Summary Human pluripotent stem cells (PSCs) through somatic cell nuclear transfer (SCNT) may be an important source for regenerative medicine. The low derivation efficiency of stem cells and the accessibility of human oocytes are the main obstacles to their application. We previously reported that the efficiency of SCNT was increased by overexpression of H3K9me3 demethylase. Here, we applied a modified derivation method to the PSC line and first obtained human SCNT-PSC lines derived from both do...
2 CitationsSource
#1Michael J. Chen (Harvard University)H-Index: 13
#2Edroaldo Lummertz da Rocha (Harvard University)H-Index: 13
Last. Thorsten M. SchlaegerH-Index: 35
view all 21 authors...
Studies of hematopoietic stem cell (HSC) development from pre-HSC-producing hemogenic endothelial cells (HECs) are hampered by the rarity of these cells and the presence of other cell types with overlapping marker expression profiles. We generated a Tg(Runx1-mKO2; Ly6a-GFP) dual reporter mouse to visualize hematopoietic commitment and study pre-HSC emergence and maturation. Runx1-mKO2 marked all intra-arterial HECs and hematopoietic cluster cells (HCCs), including pre-HSCs, myeloid- and lymphoid...
2 CitationsSource
#1Alena Yermalovich (Harvard University)H-Index: 7
#2Jihan K. Osborne (Harvard University)H-Index: 12
Last. George Q. Daley (Harvard University)H-Index: 128
view all 13 authors...
2 CitationsSource