Ian Craven
Leeds Teaching Hospitals NHS Trust
Compound heterozygosityRadiologyNeurosurgerySurgeryMutantDiffusion MRIMolecular biologySusceptibility weighted imagingExome sequencingProspective cohort studyEmergency medicineDiffuse axonal injuryLeukodystrophyExternal fixationOligodendrocyteInfarctionMajor traumaHead injuryAlexander diseaseFat embolismLeukoencephalopathyNeuromaComaCentrum semiovalePeripheral neuropathyNeuropathologyProtocol (science)Glial fibrillary acidic proteinBrain herniationTraumatic brain injuryFemoral Shaft FractureVestibular SchwannomasCerebral hypomyelinationNeurological injuryPetechial rashEndolysosomeMr imagingExonMutationGeneticsGadoliniumNeuroimagingBioinformaticsMedicineMissense mutationBiology
Publications 6
#1Guy M. Lenk (UM: University of Michigan)H-Index: 23
#2Ian R. Berry (Leeds Teaching Hospitals NHS Trust)H-Index: 9
Last. Miriam H. Meisler (Leeds Teaching Hospitals NHS Trust)H-Index: 66
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The lipid phosphatase gene FIG4 is responsible for Yunis-Varon syndrome and Charcot-Marie-Tooth disease Type 4J, a peripheral neuropathy. We now describe four families with FIG4 variants and prominent abnormalities of central nervous system (CNS) white matter (leukoencephalopathy), with onset in early childhood, ranging from severe hypomyelination to mild undermyelination, in addition to peripheral neuropathy. Affected individuals inherited biallelic FIG4 variants from heterozygous parents. Cult...
7 CitationsSource
#1Stuart Currie (Leeds Teaching Hospitals NHS Trust)H-Index: 13
#2David Saunders (Leeds Teaching Hospitals NHS Trust)H-Index: 1
Last. Ian Craven (Leeds Teaching Hospitals NHS Trust)H-Index: 4
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Objectives: To examine whether the model of Getting It Right First Time (GIRFT) could be relevant to the surveillance of non-operated vestibular schwannomas (vs) by testing the following hypotheses...
3 CitationsSource
#1Lydia Green (Leeds Teaching Hospitals NHS Trust)H-Index: 3
#2Ian R. Berry (St James's University Hospital)H-Index: 9
Last. John H. Livingston (Leeds Teaching Hospitals NHS Trust)H-Index: 31
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Alexander disease (AD) is a leukodystrophy caused by heterozygous mutations in the gene encoding the glial fibrillary acidic protein (GFAP). Currently, de novo heterozygous missense mutations in the GFAP gene are identified in over 95% of patients with AD. However, patients with biopsy-proven AD have been reported in whom no GFAP mutation has been identified. We report identical twin boys presenting in infancy with seizures and developmental delay in whom MR appearances were suggestive of AD wit...
4 CitationsSource
#1Stuart Currie (Leeds Teaching Hospitals NHS Trust)H-Index: 13
#2Nayyar Saleem (Leeds Teaching Hospitals NHS Trust)H-Index: 1
Last. Ian Craven (Leeds Teaching Hospitals NHS Trust)H-Index: 4
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Traumatic brain injury (TBI) constitutes injury that occurs to the brain as a result of trauma. It should be appreciated as a heterogeneous, dynamic pathophysiological process that starts from the moment of impact and continues over time with sequelae potentially seen many years after the initial event. Primary traumatic brain lesions that may occur at the moment of impact include contusions, haematomas, parenchymal fractures and diffuse axonal injury. The presence of extra-axial intracranial le...
60 CitationsSource
#1Sayan Datta (Leeds Teaching Hospitals NHS Trust)H-Index: 2
Last. Oliver Lily (Leeds Teaching Hospitals NHS Trust)H-Index: 1
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We present two cases of cerebral fat embolism. Both patients were 21-years old, male and involved in high impact road traffic collisions with no immediate neurological deficits. Patient A underwent intra-medullary nailing of right tibia/fibular fractures within 12 hours, and had external fixation for bilateral distal femoral fractures. Post-operatively, GCS was 6. Subsequent intracranial MR imaging showed widespread cerebral hypointense punctate foci on SWI (susceptibility-weighted imaging), som...