Shengtian Zhao
Shandong University
CancerUrologySurgeryPathologyCellMolecular biologyChemistryDecellularizationNocturnal penile tumescencePenisPremature ejaculationErectile dysfunctionKidneyCancer researchMedicineCell cultureBlood pressureBiologyScaffoldCell biology
30Publications
13H-index
565Citations
Publications 28
Newest
#1Zhi-He Xu (SDU: Shandong University)H-Index: 2
Last. Shengtian Zhao (SDU: Shandong University)H-Index: 13
view all 8 authors...
Previous studies have shown that elevated levels of high-density lipoprotein (HDL) could inhibit penile erection, but the relationship between HDL and the erection of the penile tip or base has not been extensively researched. We investigated the effects of HDL on erection of the penile tip and base through a cross-sectional study of 113 patients with erectile dysfunction, using a cut-off score of ≤21 on the International Index of Erectile Function-5. The following patient data were collected: n...
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#1Xin-He Xu (SDU: Shandong University)H-Index: 1
#2Zhi-He Xu (SDU: Shandong University)H-Index: 2
Last. Shengtian ZhaoH-Index: 3
view all 5 authors...
Previous studies have suggested that there is a positive correlation between prostate-specific antigen (PSA) levels and prostate volume (PV). A better understanding of the possible influence of PV on a ratio of free to total PSA (f/tPSA) may improve the diagnostic value of the prostate disease. The study group consisted of 342 men with lower urinary tract symptoms (LUTS). All patients underwent urinary tract ultrasonography and had tests carried out on PSA, serum glucose, total cholesterol, trig...
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#1Jiliang Wen (SDU: Shandong University)H-Index: 2
#2Zhenghao Chen (SDU: Shandong University)H-Index: 1
Last. Xiulin Zhang (SDU: Shandong University)H-Index: 5
view all 7 authors...
Bladder urothelial cells have been implicated in bladder mechanosensory transduction. Cell deformation caused by tension forces at an air-liquid interface (ALI) can induce intracellular Ca2+ concentration ( [Ca2+]i) increase and ATP release in some epithelial cells. In this study, we aimed to examine the cellular mechanisms underlying ALI induced [Ca2+]i increase in cultured urothelial cells. ALI was created by stopping the influx of the perfusion but maintaining efflux. [Ca2+]i increase were me...
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#1Jiliang Wen (SDU: Shandong University)H-Index: 2
#2Zhenghao Chen (SDU: Shandong University)H-Index: 1
Last. Xiulin Zhang (SDU: Shandong University)H-Index: 5
view all 7 authors...
Abstract Previous studies have revealed an impairment in bladder sensory transduction in aged animals. To examine the contributions of electrical property changes of bladder primary afferents to this impairment, we compared the electrical properties of dorsal root ganglion (DRG) neurons innervating the bladder among young (3 months), middle-aged (12 months), and old (24 months) female rats. The DRG neurons were labeled using axonal tracing techniques. Whole-cell current-clamp recordings of small...
1 CitationsSource
#1Liqiang Guo (SDU: Shandong University)H-Index: 6
#2Shengtian ZhaoH-Index: 13
Last. Mingzhen YuanH-Index: 8
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BACKGROUND: Since SARS-CoV-2 infection was first identified in December 2019, the novel coronavirus-induced pneumonia COVID-19 spread rapidly and triggered a global pandemic. Recent bioinformatics evidence suggests that angiotensin converting enzyme 2-the main cell entry target of SARS-CoV-2-is predominantly enriched in spermatogonia, Leydig and Sertoli cells, which suggests the potential vulnerability of the male reproductive system to SARS-CoV-2 infection. OBJECTIVES: To identify SARS-CoV-2 RN...
26 CitationsSource
#1Shan JiangH-Index: 1
#2Zhi-He XuH-Index: 2
Last. Shengtian ZhaoH-Index: 13
view all 7 authors...
The clear cell, chromophobe and papillary carcinoma as well as oncocytoma are the most common renal tumours. While cases of hybrid renal tumours are well known, the true collision renal tumour of oncocytoma and Papillary Renal Cell Carcinoma (PRCC) is still rare.
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#1Dong Pan (SDU: Shandong University)H-Index: 1
#2Zhi-He Xu (SDU: Shandong University)H-Index: 2
Last. Shengtian ZhaoH-Index: 3
view all 6 authors...
Previous studies have found that the ratio of estradiol to testosterone (E2/T ratio) has a negative effect on sexual function, but the relationship between the E2/T ratio and erection of the penis is not clarified. We conducted a retrospective study of 183 patients with erectile dysfunction and 52 healthy men to investigate the relationship between penis base erection and tip erection. All participants underwent nocturnal penile tumescence tests and medical history checks and had relevant bioche...
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#1Denglu Zhang (SDUTCM: Shandong University of Traditional Chinese Medicine)H-Index: 3
#2Xiaohang Du (SDU: Shandong University)H-Index: 2
Last. Shengtian Zhao (SDU: Shandong University)H-Index: 13
view all 7 authors...
The shortage of transplantable organs impedes the development of tissue-engineered alternatives. Producing tissues similar to immature kidneys from pluripotent stem cells is possible in vitro, but the size of the organoids is limited. Furthermore, in vivo implantation is necessary for organoid development and functional maturation. In the present study, the induction procedure was optimized and kidney organoids derived from induced pluripotent stem cells in vitro were produced. The kidney organo...
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#1Yanxia Guo (SDU: Shandong University)H-Index: 7
#2Xiaotian Yuan (SDU: Shandong University)H-Index: 5
Last. Dawei Xu (KI: Karolinska Institutet)H-Index: 41
view all 15 authors...
TERT promoter mutations occur in the majority of glioblastoma, bladder cancer (BC), and other malignancies while the ETS family transcription factors GABPA and its partner GABPB1 activate the mutant TERT promoter and telomerase in these tumors. GABPA depletion or the disruption of the GABPA/GABPB1 complex by knocking down GABPB1 was shown to inhibit telomerase, thereby eliminating the tumorigenic potential of glioblastoma cells. GABPA/B1 is thus suggested as a cancer therapeutic target. However,...
9 CitationsSource
#1Zhenghao Chen (SDU: Shandong University)H-Index: 1
#2Mingzhen Yuan (SDU: Shandong University)H-Index: 8
Last. Liqiang Guo (SDU: Shandong University)H-Index: 6
view all 10 authors...
BACKGROUND: Penile hypersensitivity is one of the main pathological mechanisms of premature ejaculation. However, little is known about the neurophysiological mechanism of penile peripheral nerve sensitization. Piezo Type Mechanosensitive Ion Channel Component 2 (PIEZO2), was recently identified as a mechanically sensitive channel. OBJECTIVES: This study explored the possible neural mechanisms of PIEZO2 action in the mechanisms of premature ejaculation using molecular biology and electrophysiolo...
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