Sylvie Changotade
University of Paris
OsseointegrationBiomedical engineeringCell migrationPathologyAdsorptionComposite materialChemistryViscoelasticityExtracellular matrixMaterials scienceMesenchymal stem cellIn vitroIn vivoStyreneBiomaterialMaxillary sinusSinus (anatomy)Platelet-rich plasmaFibroblastStem cellConnective tissue metabolismBone regenerationElastomerChemical engineeringTissue engineeringTitaniumConnective tissuePolymerViability assayPorosityMedicineAdhesionProtein adsorptionScaffoldCell biology
23Publications
10H-index
404Citations
Publications 21
Newest
#1Maroun Bou Karam (""St. Joe's"": Saint Joseph's University)
#2Joe Khoury (""St. Joe's"": Saint Joseph's University)H-Index: 1
Last. Karim SenniH-Index: 12
view all 10 authors...
Abstract Heparan sulfate glycosaminoglycans are key players of tissue repair and can be regarded as useful compounds for regenerative medicines. Unfortunately, their therapeutic uses face many technical, industrial, and regulatory hurdles due to their animal origin. So, some non-animal sulfated polysaccharides mimic heparan sulfate properties and offer interesting solutions to replace them. Among them, dextran derivatives, seaweed polysaccharides, or marine bacterial polysaccharides are the best...
Source
#1Credson Langueh (Sorbonne)H-Index: 2
#2Sylvie Changotade (Sorbonne)H-Index: 10
Last. Géraldine Rohman (Sorbonne)H-Index: 7
view all 5 authors...
Abstract Biodegradable elastomers face a growing use in soft tissue engineering due to the possibility to tune, by an appropriate selection of the synthesis and process conditions, the material thermo-mechanical properties to match the stress–strain behavior of the tissue to replace. However, changes in material properties can impact drastically the scaffold durability and therefore the efficiency of tissue reconstruction. Few studies focus on approaches allowing the prediction of the scaffold l...
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#1Géraldine Rohman (University of Paris)H-Index: 7
#2Salah Ramtani (University of Paris)H-Index: 15
Last. Philippe Djemia (Sorbonne)H-Index: 10
view all 8 authors...
Biodegradable poly(ester-urethane)-based scaffolds with an elastomeric character offer special mechanical properties by reducing the mismatch of Young’s modulus between rigid thermoplastic scaffolds classically used, and soft and dynamic tissues to regenerate (skin, tendons, muscles). In this study, porous scaffolds had been elaborated by using a high internal phase emulsion process with variable pores size (150–1800 μm), a porosity of 85% and sufficient strength making them suitable for cell cu...
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#1Géraldine Rohman (University of Paris)H-Index: 7
#2Sylvie Changotade (University of Paris)H-Index: 10
Last. Didier Lutomski (University of Paris)H-Index: 16
view all 8 authors...
: Bone loss can occur as a result of various pathologies, traumas and injuries and poor bone healing leads to functionally debilitating condition, loss of self-sufficiency and deterioration in life quality. Given the increasing incidence of facial trauma and the emergence of new procedural techniques, advanced scaffolds are currently developed as substitutes for bone tissue engineering. In this study, we investigated the capability of a chemically cross-linked e-caprolactone-based poly(ester-ure...
2 CitationsSource
#1Géraldine Rohman (University of Paris)H-Index: 7
#2Credson Langueh (University of Paris)H-Index: 2
Last. Sylvie Changotade (University of Paris)H-Index: 10
view all 7 authors...
Due to their elastomeric behavior, polyurethane-based scaffolds can find various applications in soft-tissue engineering. However, their relatively inert surface has to be modified in order to improve cell colonization and control cell fate. The present study focuses on porous biodegradable scaffolds based on poly(ester-urea-urethane), functionalized concomitantly to the scaffold elaboration with low-molecular-weight (LMW) fucoidan; and their bio-activation with platelet rich plasma (PRP) formul...
12 CitationsSource
#1Géraldine Rohman (University of Paris)H-Index: 7
#2Salah Ramtani (University of Paris)H-Index: 15
Last. Philippe Djemia (University of Paris)H-Index: 10
view all 9 authors...
In tissue engineering, porous biodegradable scaffolds are developed with morphological, chemical and mechanical properties to promote cell response. Therefore, the scaffold characterization at a (sub)micrometer and (bio)molecular level is paramount sincecells are sensitive to the chemical signals, the rigidity, and the spatial structuring of their microenvironment. In addition to the analysis at room temperature by conventional quasi-static (0.1–45 Hz) mechanical tests, the ultrasonic (10 MHz) a...
6 CitationsSource
#1Sandra Chakar (""St. Joe's"": Saint Joseph's University)H-Index: 1
#2Sylvie Changotade (Sorbonne)H-Index: 10
Last. Issam Khalil (""St. Joe's"": Saint Joseph's University)H-Index: 6
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Objectives: The purpose of this study was to evaluate the cytotoxicity of a new bioceramic-based root canal sealer (BioMM) by direct and indirect contact with human fibroblasts and to compare it with a zinc oxide-eugenol sealer, the Pulp Canal Sealer-extended working time (PCS-EWT). Materials and Methods: Cell viability was assessed through direct and indirect contact between human fibroblasts and sealer. Direct contact was performed at 24 h, whereas the indirect contact was performed at 24 and ...
5 CitationsSource
#1Sophiane Oughlis (University of Paris)H-Index: 1
#2Sylvie Changotade (University of Paris)H-Index: 10
Last. Didier Lutomski (University of Paris)H-Index: 16
view all 9 authors...
In order to replace damaged or lost bone in the human body, it is necessary to produce ‘spare body parts’ which are dependent on the use of biomaterial and stem cells and are referred to as ‘tissue engineering’. Surface modification and stem cell interaction of orthopaedic implants offer a promising approach and are investigated here specifically to improve osseointegration of the biomaterial. Osseointegration of titanium implants used in orthopaedic surgery requires that osseo-progenitor cells ...
2 CitationsSource
#1S. Lessim (University of Paris)H-Index: 3
#2S. Oughlis (University of Paris)H-Index: 4
Last. Florence Poirier (University of Paris)H-Index: 16
view all 7 authors...
Immediately after surgical placement of biomaterials, a first step consists in the adsorption of proteins from the biological environment on the artificial surfaces. Because the composition of the adsorbed protein layer modulates the cell response to the implanted material, researchers in the biomaterials field have focused on coating proteins or peptides onto surfaces to improve cell response and therefore the long-term compatibility of the implant. However, some materials used in tissue engine...
6 CitationsSource