T. A. Anikina
Kazan Federal University
Isometric exerciseEndocrinologyRepolarizationInotropeTyrosine hydroxylaseContraction (grammar)ReceptorMembrane potentialChemistryImmunohistochemistryCatecholamineWestern blotAutonomic nervous systemUridine triphosphateAgonistOntogenyContractilityMedicineBiologyNeuropeptide Y receptor
11Publications
3H-index
26Citations
Publications 10
Newest
#1A. A. Zverev (Kazan: Kazan Federal University)H-Index: 2
#2T. A. Anikina (Kazan: Kazan Federal University)H-Index: 3
Last. Timur L. Zefirov (Kazan: Kazan Federal University)H-Index: 5
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The effects of neuropeptide Y (10—9-10—6 M) on electrical activity of right atrial cardiomyocytes of rats aging 7, 21, and 100 days were examined in vitro. Neuropeptide Y affected the amplitude-temporal parameters of the action potential in these cells. It decreased the duration of repolarization phase in 7-day-old rats in concentrations of 10—8 and 10—7 M, in 21-day-old rats at 10—8 and 10—6 M, and in 100-day-old at 10—6 M. The data indicate elevation of total membrane potassium current under t...
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#1A. A. Zverev (Kazan: Kazan Federal University)H-Index: 2
#2T. A. Anikina (Kazan: Kazan Federal University)H-Index: 3
Last. Timur L. Zefirov (Kazan: Kazan Federal University)H-Index: 5
view all 5 authors...
: We studied the effect of neuropeptide Y in concentrations of 10-8-10-6 M on electrical activity of adult rat right atrial cardiomyocytes with preserved spontaneous activity. Neuropeptide Y was found to modulate the amplitude-time parameters of action potential: in concentrations of 10-7 and 10-6 M it reduced the membrane potential, increased the amplitude of action potential and duration of the repolarization phase, and reduced the frequency of action potential generation. In concentration of ...
1 CitationsSource
#1P. M. MasliukoH-Index: 1
#2T. A. Anikina (Kazan: Kazan Federal University)H-Index: 3
Last. Timur L. Zefirov (Kazan: Kazan Federal University)H-Index: 5
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: Selective agonist (Leu(31)Pro(34)NPY) and blocker (BIBP-3226) of NPY1 receptors were used to determine the type of NPY receptors involved in myocardial contraction. Experiments with isometric contraction of myocardial strips from mature rats showed that the agonist produced the most potent effect in a concentration of 10-7 M. In this concentration, Leu(31)Pro(34)NPY showed the greatest positive inotropic effect on the contraction of the atria and ventricles. In contrast, selective blocker BIBP...
6 CitationsSource
#1Petr M. MasliukovH-Index: 10
#2Konstantin MoiseevH-Index: 4
Last. T. A. Anikina (Kazan: Kazan Federal University)H-Index: 3
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#1Petr M. MasliukovH-Index: 10
#2Konstantin MoiseevH-Index: 4
Last. Nozdrachev Ad (SPbU: Saint Petersburg State University)H-Index: 11
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Abstract Neuropeptide Y (NPY) plays a trophic role in the nervous and vascular systems and in cardiac hypertrophy. However, there is no report concerning the expression of NPY and its receptors in the heart during postnatal development. In the current study, immunohistochemistry and Western blot analysis was used to label NPY, and Y1R, Y2R, and Y5R receptors in the heart tissue and intramural cardiac ganglia from rats of different ages (newborn, 10 days old, 20 days old, 30 days old, 60 days old...
10 CitationsSource
#1A. A. Zverev (Kazan: Kazan Federal University)H-Index: 2
#2T. A. Anikina (Kazan: Kazan Federal University)H-Index: 3
Last. T. L. Zefi rov (Yaroslavl State Medical Academy)H-Index: 1
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We studied the effect of neuropeptide Y in concentrations of 10–10-10–6 M on myocardial contractility of rats at the age of 7, 21, and 100 days. Studying the isometric contraction of myocardial strips showed that neuropeptide Y decreases the force of myocardial contraction in 7-day-old rat pups. Exogenous neuropeptide Y produced a biphasic effect in 21-day-old rats, which was manifested in the increase and subsequent decrease in myocardial contractility. Neuropeptide Y had little effect on myoca...
3 CitationsSource
#1T. A. Anikina (Kazan: Kazan Federal University)H-Index: 3
#2I. N. Anisimova (Kazan: Kazan Federal University)H-Index: 2
Last. Timur L. Zefirov (Kazan: Kazan Federal University)H-Index: 5
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Experiments with R2Y receptor blockers allowed identification of R2Y subtypes mediating the inhibitory effects of uridine triphosphate on myocardial contractility. In 100-day-old animals, the myocardial inotropic response to the administration of uridine triphosphate was mediated by R2Y2 receptors. R2Y4 receptors took part in the realization of negative inotropic response to uridine triphosphate in all age groups, but the most pronounced effects of this substance on myocardial contractility were...
2 CitationsSource
#1Petr M. Masliukov (Yaroslavl State Medical Academy)H-Index: 10
#2A. I. Emanuilov (Yaroslavl State Medical Academy)H-Index: 7
Last. F.G. Sitdikov (Kazan: Kazan Federal University)
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We studied the effect of uridine 5’-triphosphate in concentrations of 1010-106 M on myocardial contractile activity in 7-100-day-old rats. Analysis of isometric contraction of myocardial strips showed that uridine 5’-triphosphate reduced the strength of myocardial contraction in rats of all age groups. In 21and 100-day-old rat pups, exogenous uridine 5’-triphosphate produced a stronger inhibitory effect than in 7-day-old animals. The negative inotropic effect of UTP was abolished under conditi...
4 CitationsSource