Geetanjali Sachdeva
National Institute for Research in Reproductive Health
GeneInternal medicineEndocrinologyMolecular biologyAndrologyReceptorEmbryoImmunohistochemistryEstrogenMenstrual cycleUterusEndometriosisEndometriumGynecologyCancer researchMedicineCell cultureEstrogen receptorBiologyCell biologyProgesterone receptor
60Publications
18H-index
803Citations
Publications 62
Newest
#1V Venkatappa (IISc: Indian Institute of Science)
Last. Polani B. Seshagiri (IISc: Indian Institute of Science)H-Index: 17
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#1Madhulika Pathak (IISc: Indian Institute of Science)H-Index: 1
#2V Venkatappa (IISc: Indian Institute of Science)
Last. Polani B. Seshagiri (IISc: Indian Institute of Science)H-Index: 17
view all 9 authors...
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#1Itti Munshi (National Institute for Research in Reproductive Health)
#1Itti Munshi (National Institute for Research in Reproductive Health)
Last. Uddhav Chaudhari (National Institute for Research in Reproductive Health)H-Index: 7
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Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has caused millions of fatalities globally since its origin in November 2019. The SARS-CoV-2 shares 79 and 50 per cent genome similarity with its predecessors, severe SARS-CoV and Middle East respiratory syndrome (MERS) coronavirus, all belonging to the same genus, Betacoronavirus. This relatively new virus has stymied the effective control of COVID-19 pandemic and caused huge social and economic impact worldwide. The FDA-approved drugs ...
1 CitationsSource
#1Kashmira Bane (National Institute for Research in Reproductive Health)
#2Junita Desouza (National Institute for Research in Reproductive Health)
Last. Geetanjali Sachdeva (National Institute for Research in Reproductive Health)H-Index: 18
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STUDY QUESTION Is the DNA damage response (DDR) dysregulated in the eutopic endometrium of women with endometriosis? SUMMARY ANSWER Endometrial expression of genes involved in DDR is modulated in women with endometriosis, compared to those without the disease. WHAT IS KNOWN ALREADY Ectopic endometriotic lesions are reported to harbour somatic mutations, thereby hinting at dysregulation of DDR and DNA repair pathways. However, it remains inconclusive whether the eutopic endometrium also manifests...
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#1Ruchi Kakar-Bhanot (National Institute for Research in Reproductive Health)H-Index: 1
#2Krupanshi Brahmbhatt (National Institute for Research in Reproductive Health)H-Index: 1
Last. Geetanjali Sachdeva (National Institute for Research in Reproductive Health)H-Index: 18
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Human endometrial epithelium (EE) is composed of a multitude of proteins, amongst which those localized on the plasma membrane [plasma membrane proteins (PMPs)] are of critical relevance in the early stages of implantation. Evidence supports the key role of few PMPs in implantation. However, many remain unidentified, as efforts have not been made till date to generate the plasma membrane proteome of human EE cells, using a gel-free approach. This study presents a protein catalog of the PMP enric...
1 CitationsSource
#1Sushama Gadkar (National Institute for Research in Reproductive Health)H-Index: 7
#2Shardool Nair (National Institute for Research in Reproductive Health)H-Index: 2
Last. Geetanjali Sachdeva (National Institute for Research in Reproductive Health)H-Index: 18
view all 8 authors...
: The plasma membrane (PM) is considered as a major druggable site. More than 50% of the existing drugs target PM proteins. In the wake of emerging data indicating a key role of estrogens in prostate cancer (PCa) pathogenesis, the study was undertaken to explore whether the estrogen binding sites exist on the PM and if such sites are functionally relevant in PCa. Estradiol (E2) binding to the PM was detected in androgen-dependent (LNCaP), androgen-independent (PC3, DU145) PCa cell lines, nontumo...
4 CitationsSource
#1Ruchi Kakar-Bhanot (National Institute for Research in Reproductive Health)H-Index: 1
#2Krupanshi Brahmbhatt (National Institute for Research in Reproductive Health)H-Index: 1
Last. Geetanjali Sachdeva (National Institute for Research in Reproductive Health)H-Index: 18
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STUDY QUESTION: Is Rab11a GTPase, a regulator of intracellular trafficking, of significance in endometrial functions? SUMMARY ANSWER: Rab11a is an important component of the cascades involved in equipping the endometrial epithelium (EE) with 'adhesiveness' and 'cohesiveness'. WHAT IS KNOWN ALREADY: Cell adhesion molecules (CAMs) have been investigated extensively for modulation in their endometrial expression during the peri-implantation phase. However, the mechanisms by which CAMs are transport...
12 CitationsSource
#1Junita Desouza (ICMR: Indian Council of Medical Research)H-Index: 1
#2Sushama Gadkar (ICMR: Indian Council of Medical Research)H-Index: 7
Last. Geetanjali Sachdeva (ICMR: Indian Council of Medical Research)H-Index: 18
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Estrogens are implicated in a diverse range of functions varying from reproduction, circulation, skeletal health to neuroprotection. Estrogens are also being increasingly recognized for their pathological contribution to cancers of various organs. This has spurred several investigations on estrogen-initiated signaling mechanisms in various cell types in physiological and pathological conditions. Estrogens exert their biological actions through a class of conventional nuclear receptors known as e...
1 CitationsSource
#1Rucha Saoji (National Institute for Research in Reproductive Health)H-Index: 2
#2Rajat S. Das (Government Medical College, Thiruvananthapuram)H-Index: 2
Last. M. Ikram Khatkhatay (National Institute for Research in Reproductive Health)H-Index: 9
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Summary This study investigated association between lipids and homocysteine (Hcy) with bone mineral density (BMD) in young women as opposed to previous studies on elderly women. HDL, triglyceride, and Hcy are significantly associated with BMD in young women and tobacco and alcohol consumption have no effect on this association.
8 CitationsSource
#1Shardool Nair (National Institute for Research in Reproductive Health)H-Index: 2
#2Geetanjali Sachdeva (National Institute for Research in Reproductive Health)H-Index: 18
Abstract Metastatic cancer cells meet several physical, biochemical and immunological barriers before colonizing a new territory. Cancerous cells turn invasive, mobile and eventually disengage from their native niche. This is followed by their intravasation, extravasation, survival, proliferation, and colonization into distant organs. Unlike well-confined tumors, which respond favorably to anti-cancer therapeutics, metastatic tumors are life-threatening and incurable. More than 90% of cancer-rel...
3 CitationsSource