Wilma E. Mesker
Leiden University Medical Center
CancerH&E stainInternal medicinePathologyOncologyStromal cellStage (cooking)ChemistryPrimary tumorLymph nodeTumor stromaCancer researchStromaColorectal cancerBreast cancerMedicineBiomarker (medicine)BiologyGastroenterology
Publications 174
#1Marloes A Smit (LUMC: Leiden University Medical Center)H-Index: 1
#2Gabi W. van Pelt (LUMC: Leiden University Medical Center)H-Index: 10
Last. J. Han van Krieken (Radboud University Nijmegen)H-Index: 60
view all 7 authors...
The tumour-stroma ratio (TSR) and tumour budding (TB) are two high-risk factors with potential to be implemented in the next TNM classification. The aim of the current study was to evaluate the practical application of the two biomarkers based on reproducibility, independency and prognostic value. Patients diagnosed with stage II or III colon cancer who underwent surgery between 2005 and 2016 were included. Both TSR and TB were scored on haematoxylin and eosin-stained tissue sections. The TSR, b...
Artificial Intelligence (AI) can potentially support histopathologists in the diagnosis of a broad spectrum of cancer types. In colorectal cancer (CRC), AI can alleviate the laborious task of characterization and reporting on resected biopsies, including polyps, the numbers of which are increasing as a result of CRC population screening programs, ongoing in many countries all around the globe. Here, we present an approach to address two major challenges in automated assessment of CRC histopathol...
#1Sophie C. Hagenaars (LUMC: Leiden University Medical Center)H-Index: 1
#2Stefanie de Groot (LUMC: Leiden University Medical Center)H-Index: 5
Last. Wilma E. Mesker (LUMC: Leiden University Medical Center)H-Index: 33
view all 12 authors...
The tumor-stroma ratio (TSR) has proven to be a strong prognostic factor in breast cancer, demonstrating better survival for patients with stroma-low tumors. Since the role of the TSR as a predictive marker for neoadjuvant chemotherapy outcome is yet unknown, this association was evaluated for HER2-negative breast cancer in the prospective DIRECT and NEOZOTAC trials. The TSR was assessed on 375 hematoxylin and eosin-stained sections of pre-treatment biopsies. Associations between the TSR and che...
#1Randa G. Hanna-Sawires (LEI: Leiden University)
#2Jesse V. Groen (LEI: Leiden University)H-Index: 5
Last. Frederikus A. Klok (LEI: Leiden University)H-Index: 51
view all 11 authors...
Abstract null null Introduction null Pancreatic cancer is associated with a high risk of venous thromboembolism (VTE). However, comprehensive data on incidence, timing and relevant determinants of VTE in this particular population are scarce. Current study assesses incidence, timing and predictors of VTE in pancreatic cancer through different phases of disease. null null null Methods null All pancreatic cancer patients treated in our tertiary referral center between 2013 through 2017 were studie...
#1Iris J. M. Levink (EUR: Erasmus University Rotterdam)H-Index: 2
#2Derk Klatte (LEI: Leiden University)
Last. Manfred Wuhrer (LEI: Leiden University)H-Index: 83
view all 17 authors...
Background: Surveillance of individuals at risk of developing pancreatic ductal adenocarcinoma (PDAC) has the potential to improve survival, yet early detection based on solely imaging modalities is challenging. Alternatively, individuals with lesions progressing to malignancy can be recognized by molecular biomarkers. We aimed to identify changes in serum protein glycosylation levels over time to earlier detect PDAC in high-risk individuals undergoing surveillance. Methods: Individuals with a h...
#1Iris J. M. LevinkH-Index: 2
#2Derk C.F. KlatteH-Index: 1
Last. Wilma E. MeskerH-Index: 33
view all 14 authors...
#1Gerda C. M. Vreeker (LUMC: Leiden University Medical Center)H-Index: 5
#2Kiki M.H. Vangangelt (LUMC: Leiden University Medical Center)H-Index: 4
Last. Rob A. E. M. Tollenaar (LUMC: Leiden University Medical Center)H-Index: 71
view all 8 authors...
Breast cancer is the most prevalent cancer in women. Early detection of this disease improves survival and therefore population screenings, based on mammography, are performed. However, the sensitivity of this screening modality is not optimal and new screening methods, such as blood tests, are being explored. Most of the analyses that aim for early detection focus on proteins in the bloodstream. In this study, the biomarker potential of total serum N-glycosylation analysis was explored with reg...
#1Marloes A Smit (LUMC: Leiden University Medical Center)H-Index: 1
#2Gabi W. van Pelt (LUMC: Leiden University Medical Center)H-Index: 10
Last. Wilma E. Mesker (LUMC: Leiden University Medical Center)H-Index: 33
view all 7 authors...
BACKGROUND The amount of stroma in the primary tumor is an important prognostic parameter. The tumor-stroma ratio (TSR) was previously validated by international research groups as a robust parameter with good interobserver agreement. OBJECTIVE The Uniform Noting for International Application of the Tumor-Stroma Ratio as an Easy Diagnostic Tool (UNITED) study was developed to bring the TSR to clinical implementation. As part of the study, an e-Learning module was constructed to confirm the repro...
#1Randa G. Hanna‐Sawires (LUMC: Leiden University Medical Center)H-Index: 1
Last. Rob A. E. M. TollenaarH-Index: 71
view all 9 authors...
Pancreatic ductal adenocarcinoma (PDAC) is known as a highly aggressive malignant disease. Prognosis for patients is notoriously poor, despite improvements in surgical techniques and new (neo)adjuvant chemotherapy regimens. Early detection of PDAC may increase the overall survival. It is furthermore foreseen that precision medicine will provide improved prognostic stratification and prediction of therapeutic response. In this review, omics-based discovery efforts are presented that aim for novel...
3 CitationsSource
#1Susana I.S. Patuleia (UU: Utrecht University)H-Index: 1
#2Sophie C. Hagenaars (LUMC: Leiden University Medical Center)H-Index: 1
Last. Elsken van der Wall (UU: Utrecht University)H-Index: 41
view all 9 authors...
Women identified with an increased risk of breast cancer due to mutations in cancer susceptibility genes or a familial history of breast cancer undergo tailored screening with the goal of detecting tumors earlier, when potential curative interventions are still possible. Ideally, screening would identify signs of carcinogenesis even before a tumor is detectable by imaging. This could be achieved by timely signaling of altered biomarker levels for precancerous processes in liquid biopsies. Curren...
1 CitationsSource