Falk Gühne
Internal medicineRadiologyUrologyPET-CTPathologyUltrasoundResidualRenal functionPositron emission tomographyThyroidectomyAdenomaLungNodule (medicine)Thyroid nodulesScintigraphyCreatinineAngiographyTransarterial RadioembolizationMinimal activityNuclear medicineMultimodal imagingThyroid carcinomaClinical routineCase filesResidual activityPsma pet ctThyroidUltrasonographyComputed tomographyImage fusionText miningMedicineVialDistribution (pharmacology)
34Publications
4H-index
65Citations
Publications 34
Newest
#1Falk GühneH-Index: 4
Last. Martin FreesmeyerH-Index: 14
view all 5 authors...
Background: In addition to its SSTR-specific binding in tumors and healthy tissues, DOTATOC analogues accumulate in kidney parenchyma. Renal tracer uptake might be a surrogate of kidney function or dysfunction. This study aimed to evaluate if kidney function can be estimated from 68Ga[Ga]-DOTATOC uptake in PET/CT and its impact on the nephrotoxicity of 177Lu[Lu]-DOTATOC PRRT. Methods: Two cohorts of patients (A: 128 diagnostic patients; B: 32 PRRT patients) were evaluated retrospectively. SUV va...
Source
#1Falk GühneH-Index: 4
#2Philipp SeifertH-Index: 9
Last. Robert DrescherH-Index: 5
view all 6 authors...
PET/CT with prostate-specific membrane antigen (PSMA)-targeted tracers has been used in the diagnosis and staging of patients with clear cell renal cell carcinoma (ccRCC). For ccRCC primary tumors, PET parameters were shown to predict histologic grade and features. The aim of this study was to correlate PSMA PET/CT with histopathological findings in patients with metastatic recurrence of ccRCC. Patients with ccRCC who underwent PSMA-targeted PET/CT and subsequent histopathological evaluation of ...
Source
#1Martin FreesmeyerH-Index: 14
#2Robert DrescherH-Index: 5
Last. Julia GreiserH-Index: 3
view all 5 authors...
ABSTRACT Tri-alkoxysalicyl-1,4-diazepan-6-amine (TAoS-DAZA) ligands, radiolabelled with 68Ga, have been proposed as PET/CT agents for depiction and quantification of hepatobiliary function and evaluation of bile excretion. In the presented case, a patient with hepatocellulary carcinoma underwent PET/CT with the TAoS-derivate 68Ga-tri-methoxysalicyl-(TMoS)-DAZA to determine the patency of intrahepatic and extrahepatic bile ducts, in particular of a stent in the common bile duct. The PET/CT was pe...
Source
#1Martin FreesmeyerH-Index: 2
#2Julia GreiserH-Index: 3
Last. Robert DrescherH-Index: 5
view all 8 authors...
Established imaging modalities for the characterization of liver tumors are computed tomography (CT), magnetical resonance (MR) imaging, sonography, and hepatobiliary scintigraphy. In some cases, their results may be inconclusive or certain examinations not possible due to contraindications. Positron emission tomography (PET)/CT has the capability of dynamic imaging with high temporal resolution. With radiolabeled tri-alkoxysalicyl-1,4-diazepan-6-amine (TAoS-DAZA) tracers, imaging of liver perfu...
Source
#1Hannah EisfeldH-Index: 2
#2Stefan KircherH-Index: 34
Last. Karin G. SchrenkH-Index: 5
view all 18 authors...
Source
#1Falk GühneH-Index: 4
#2Robert DrescherH-Index: 5
Last. Martin FreesmeyerH-Index: 14
view all 5 authors...
ABSTRACT Lung scintigraphy was performed to rule out pulmonary embolism in a 37-year-old woman suffering from dyspnea and hypoxemia after routine diagnostics failed to find the underlying disease. Perfusion scans did not show tracer uptake within the lungs despite ventilation scans being unremarkable. Instead, the result suggested a complete right-to-left shunt, which was a conundrum. With the assistance of CT an uncommon congenital vessel aberration turned out to be the cause of this exceptiona...
Source
PURPOSE To evaluate the microsphere outflow dynamics and residual Ho-166 activity during and after transarterial radioembolization planning and treatment procedures, and to assess the distribution and predilection sites of residual activity in the proprietary delivery set and the microcatheter. MATERIALS AND METHODS Fifteen planning and 12 therapeutic radioembolization procedures were performed with poly-l-lactic acid microspheres loaded with Ho-166. The amount and distribution of residual activ...
Source
Short-term follow-up examinations could verify ambiguous findings in PET/CT diagnostics, but are often avoided due to radiation and financial burdens. We demonstrate the feasibility of a focused, minimal-activity PET protocol as a supplemental examination for uncertain findings after standard PET/CT. After changing conditions, e.g. patient positioning, preparation and bypassing an interval as well as a targeted tracer change, an additional examination with less than 1 mSv of additional radiation...
Source
Source
#1Philipp SeifertH-Index: 9
Last. Martin FreesmeyerH-Index: 2
view all 7 authors...
Conventional ultrasound (US) is time-consuming, and results are subjected to high interobserver variability. In this study, the reliability of a novel thyroid US cine loop standard operating procedure (SOP) applied by non-physicians (Medical Technical Assistant, MTA) is investigated. Thirty-three consecutive patients (22 females, 11 males) were enrolled. Patients underwent conventional thyroid US performed by a nuclear medicine physician and additional MTA US cine loop according to a local SOP t...
Source