Cristian Covarrubias
University of Chile
Simulated body fluidIon exchangeNuclear chemistryAdsorptionNanoparticleCatalysisNanotechnologyInorganic chemistryChemistryPolymer chemistryMaterials scienceApatiteZeoliteBioactive glassPolyethyleneBone regenerationChemical engineeringNanoporousChromiumMesoporous materialNanocomposite
Publications 36
#1Miguel Maureira Vargas (University of Chile)
#2Felipe Cuadra (University of Chile)H-Index: 2
Last. Cristian Covarrubias (University of Chile)H-Index: 15
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Bone reconstruction in the oral and maxillofacial region presents particular challenges related to the development of biomaterials with osteoinductive properties and suitable physical characteristics for their surgical use in irregular bony defects. In this work, the preparation and bioactivity of chitosan - gelatin (ChG) hydrogel beads loaded with either bioactive glass nanoparticles (nBG) or mesoporous bioactive glass nanospheres (nMBG) were studied. In vitro testing of the bionanocomposite be...
This study aimed to investigate the cytotoxicity and bioactivity of a novel nanocomposite containing nanoparticles of bioactive glass (nBGs) on human dental pulp stem cells (hDPSCs). nBGs were synthesized by the sol–gel method. Biodentine (BD) nanocomposites (nBG/BD) were prepared with 2 and 5% wt of nBG content; unmodified BD and glass ionomer cement were used as references. Cell viability and attachment were evaluated after 3, 7 and 14 days. Odontogenic differentiation was assessed with alkali...
#1Julian Bejarano (University of Chile)H-Index: 7
#2Aldo R. Boccaccini (FAU: University of Erlangen-Nuremberg)H-Index: 114
Last. Humberto Palza (University of Chile)H-Index: 26
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Biodegradable polymer scaffolds filled with bioactive glass particles doped with therapeutic metal ions are a novel and promising strategy to repair critical-sized bone defects. In this study, scaffolds based on a poly (D, L-lactide acid) (PDLLA) matrix filled with un-doped and Cu-, Zn- and CuZn-doped bioactive glass particles were produced by freeze-drying and a salt-leaching method. The effects of the doping and content of the glass particles (10 and 30 wt.%) on the morphology, compression pro...
4 CitationsSource
#1Emilio A Cafferata (University of Chile)H-Index: 6
#2Claudia Terraza-Aguirre (University of Chile)H-Index: 2
Last. Rolando Vernal (University of Chile)H-Index: 23
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AIM: T lymphocytes play a central role during the pathogenesis of periodontitis, and the imbalance between the pathogenic T-helper type 17 (Th17) and protective T-regulatory (Treg) lymphocytes determines the tooth-supporting alveolar bone resorption. Interleukin (IL)-35 is a novel anti-inflammatory cytokine with therapeutic properties in diseases whose pathogenesis is associated with the Th17/Treg imbalance; however, its role during periodontitis has not been established yet. This study aimed to...
8 CitationsSource
#1M. Fernández-Arias (University of Vigo)H-Index: 4
#2Mohamed Boutinguiza (University of Vigo)H-Index: 23
Last. Juan Pou (University of Vigo)H-Index: 33
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Abstract The dramatic increase of antibiotic-resistant bacteria is considered one of the greatest threats to human health at global scale. The antibacterial activity of noble metal nanoparticles, could be the solution against bacterial infectious diseases which currently do not respond to conventional treatments. In this work, copper nanoparticles were produced by laser ablation using two different lasers. A nanosecond laser operating at 532nm and a picosecond laser at 1064nm were used to ablate...
8 CitationsSource
Copper nanoparticles (NCu) were synthetized and added to commercial glass ionomer cement, to evaluate in vitro its antibacterial activity against oral cavity strains. The NCu were synthesized by copper acetate reduction with L-ascorbic acid and characterized by FTIR, Raman, XPS, XRD and TEM. Then, commercial glass ionomer cement (GIC) was modified (MGIC) with various concentrations of NCu and physicochemically characterized. Cell viability was tested against human dental pulp fibroblasts (HDPFs)...
#1Emilio A Cafferata (University of Chile)H-Index: 6
#2Carla Alvarez (University of Chile)H-Index: 11
Last. Rolando Vernal (University of Chile)H-Index: 23
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: Periodontitis is an inflammatory disease, in which the host immuno-inflammatory response against the dysbiotic subgingival biofilm leads to the breakdown of periodontal tissues. Most of the available treatments seem to be effective in the short-term; nevertheless, permanent periodical controls and patient compliance compromise long-term success. Different strategies have been proposed for the modulation of the host immune response as potential therapeutic tools to take a better care of most su...
8 CitationsSource
#1Claudio Alburquenque (University of Chile)H-Index: 5
#2José Amaro (University of Chile)H-Index: 3
Last. Cecilia V. Tapia (University of Chile)H-Index: 8
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: Candida albicans is commensal yeast that colonizes skin and mucosa; however, it can become an opportunist pathogen by changing from blastoconidia (commensal form) into hypha (pathogenic form). Each form activates a different cytokines response in epithelial cells. Little is known about the commensal role of C. albicans in the innate immunity. This work studied whether stimulation with C. albicans blastoconidia induces protection in keratinocytes and/or in a reconstituted human epithelium (RHE)...
1 CitationsSource
#2Amaru AgüeroH-Index: 1
Last. Alfredo Von Marttens (University of Chile)H-Index: 6
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Abstract Bionanocomposite scaffolds based on aliphatic polyurethane (PU) and bioactive glass nanoparticles were produced by using a one-step in situ polymerization method. Bioactive glass nanoparticles (nBG) or mesoporous BG nanospheres (nMBG) were incorporated during the polymerization reaction to produce simultaneous formation and foaming of porous nanocomposite scaffolds. The in vitro bioactivity of the scaffolds was assessed in simulated body fluid (SBF), and through cytocompatibility and os...
9 CitationsSource
#1Camila Corral (University of Chile)H-Index: 3
#2Pedro Negrete (University of Chile)H-Index: 1
Last. Hernane da Silva Barud (UNESP: Sao Paulo State University)H-Index: 31
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3 CitationsSource