Rachel Brandeis
Israel Institute for Biological Research
Internal medicineEndocrinologyPathologyPsychologyNeuroscienceCognitionChemistryCholinergicAtropineAcetylcholineAgonistDiseaseMuscarinic agonistSarinSulfur mustardMuscarinic acetylcholine receptorAnesthesiaMorris water navigation taskMedicineBiologyPharmacology
69Publications
23H-index
2,226Citations
Publications 69
Newest
#1Mor Israely (HUJI: Hebrew University of Jerusalem)H-Index: 1
#2Anca RamH-Index: 1
Last. Elliot M. Berry (HUJI: Hebrew University of Jerusalem)H-Index: 55
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BACKGROUND: Anorexia nervosa (AN) is characterized by self-induced malnutrition, affecting body image, mood, cognition and survival. Tyrosine, an essential amino acid is the precursor of catecholamines. The use of tyrosine to treat AN is based on experiments on diet restricted mice, in which it increased food consumption, improved cognitive function and elevated brain catecholamines. We evaluated the effect of oral tyrosine administration on the cognition and emotional state of patients with AN....
3 Citations
#1Shlomi Lazar (Israel Institute for Biological Research)H-Index: 11
#2Inbal Egoz (Israel Institute for Biological Research)H-Index: 7
Last. Ettie Grauer (Israel Institute for Biological Research)H-Index: 15
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Abstract Sarin is an irreversible organophosphate cholinesterase inhibitor and a highly toxic warfare agent. Following the overt, dose-dependent signs (e.g. tremor, hyper secretion, seizures, respiratory depression and eventually death), brain damage is often reported. The goal of the present study was to characterize the early histopathological and biochemical events leading to this damage. Rats were exposed to 1LD50 of sarin (80 μg/kg, i.m.). Brains were removed at 1, 2, 6, 24 and 48 h and pro...
18 CitationsSource
#1Abraham Fisher (Israel Institute for Biological Research)H-Index: 32
#2Ilya BezprozvannyH-Index: 74
Last. Rodrigo Medeiros (University of California, Berkeley)H-Index: 34
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We previously developed orthosteric M1 muscarinic agonists (e.g. AF102B, AF267B and AF292), which act as cognitive enhancers and potential disease modifiers. We now report on a novel compound, AF710B, a highly potent and selective allosteric M1 muscarinic and σ1 receptor agonist. AF710B exhibits an allosteric agonistic profile on the M1 muscarinic receptor; very low concentrations of AF710B significantly potentiated the binding and efficacy of carbachol on M1 receptors and their downstream effec...
32 CitationsSource
#1Ariel Gore (Israel Institute for Biological Research)H-Index: 6
#2Rachel Brandeis (Israel Institute for Biological Research)H-Index: 23
Last. Eugenia Bloch-Shilderman (Israel Institute for Biological Research)H-Index: 6
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Eye exposure to the extremely toxic organophosphorus sarin results in long-term miosis and visual impairment. As current treatment using atropine or homatropine eye drops may lead to considerable visual side effects, alternative combined treatments of intramuscular (im) oximes (16.8mmol/kg, im) with atropine (0.5 mg/kg, im) or with the short acting antimuscarinic tropicamide (0.5%; w/v) eye drops were thus evaluated. The combined treatments efficacy following topical exposure to sarin (1mg) was ...
7 CitationsSource
#1Ophir Lavon (Medical Corps)H-Index: 8
#2Arik Eisenkraft (Medical Corps)H-Index: 16
Last. Rachel Brandeis (Israel Institute for Biological Research)H-Index: 23
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Rivastigmine, a reversible cholinesterase inhibitor, approved as a remedy in Alzheimer's disease, was suggested as pretreatment against nerve agents poisoning. We evaluated the pharmacokinetic, pharmacodynamic, physiologic, cognitive and emotional effects of repeated rivastigmine in young healthy male adults, in a double blind, placebo controlled crossover trial. Three groups completed 3 treatment periods: 0, 1.5 and 3mg twice a day, for a total of 5 intakes. Parameters monitored were: vital sig...
7 CitationsSource
#1Vered Horwitz (Israel Institute for Biological Research)H-Index: 10
#2Shlomit Dachir (Israel Institute for Biological Research)H-Index: 19
Last. Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
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AbstractPurpose: Sulfur mustard (SM) induces acute ocular lesions, including erosions and inflammation that may be followed by delayed injuries expressed by epithelial defects and neovascularization (NV). Based on the matrix metalloproteinases (MMPs) activity, we evaluated the clinical and biochemical effects of topical treatment with doxycycline, an MMP inhibitor, targeted to the various injury stages.Methods: Rabbit eyes were exposed to SM vapor. A clinical follow-up was carried out up to 2 mo...
31 CitationsSource
#1Abraham FisherH-Index: 32
#2Rodrigo Medeiros (UCI: University of California, Irvine)H-Index: 34
Last. Frank M. LaFerla (UCI: University of California, Irvine)H-Index: 108
view all 10 authors...
1 CitationsSource
#1Ariel Gore (Israel Institute for Biological Research)H-Index: 6
#2Eugenia Bloch-Shilderman (Israel Institute for Biological Research)H-Index: 6
Last. Rachel Brandeis (Israel Institute for Biological Research)H-Index: 23
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Background and Purpose Eye exposure to the organophosphorus (OP) irreversible cholinesterase inhibitor sarin results in long-term miosis and impaired visual function. We have previously shown that tropicamide is better at ameliorating this insult than topical atropine or cyclopentolate. However, to minimize side effects associated with repeated tropicamide applications and high treatment doses, we evaluated the effects of oximes (ChE re-activators) alone and combined with tropicamide at ameliora...
6 CitationsSource
#1Vered Horwitz (Israel Institute for Biological Research)H-Index: 10
#2Shlomit Dachir (Israel Institute for Biological Research)H-Index: 19
Last. Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
view all 9 authors...