Sae-Gwang Park
Inje University
Internal medicineImmunoglobulin EMolecular biologyVirologyAntibodyKinaseChemistryImmunologyT cellWestern blotOvalbuminCaffeic acid phenethyl esterCytokineLipopolysaccharideCancer researchBiochemistryMAPK/ERK pathwaySignal transductionMedicineProtein kinase BBiologyImmune systemCell biologyPharmacology
Publications 64
#1Jin-Hee Park (Inje University)H-Index: 4
#2Hee Yeon Kim (Inje University)H-Index: 1
Last. Sae-Gwang Park (Inje University)H-Index: 23
view all 9 authors...
Abstract Purpose The establishment of a preclinical model of the abscopal effect on HCC and evaluation on whether the hypofractionated RT multi-tumor Hepa1-6 mouse HCC model could be used to suppress non-radiated tumor mass would be implemented in this study. Methods and Materials Hepa1-6 mouse liver cancer cell lines were used to form tumors and immunogenicity was analyzed using ELISpot and immune cell labeled antibody. Interferonβ (IFNβ) expression was confirmed through PCR. Results After inve...
#1Xingguo Quan (Inje University)H-Index: 1
#2Beom Seok Kwak (Dongguk University)H-Index: 5
Last. Sae-Gwang Park (Inje University)H-Index: 23
view all 7 authors...
Cordyceps militaris has been widely used as a traditional medicine in East Asia. Its effects against breast cancer have been reported previously. However, whether C. militaris-induced breast cancer cell death is immunogenic remains unelucidated. This study aimed to determine whether ethanolic extracts of C. militaris (CM-EE) could induce immunogenic cell death (ICD) in breast cancer immunotherapy to improve the efficacy of immune checkpoint inhibitors. Human and mouse breast cancer cells were tr...
#1Tae Oh Kim (Inje University)H-Index: 21
#2Dong Il Park (SKKU: Sungkyunkwan University)H-Index: 51
Last. Joo Mi Yi (Inje University)H-Index: 21
view all 7 authors...
Inflammatory bowel disease is known to be associated with a genetic predisposition involving multiple genes; however, there is growing evidence that abnormal interactions with environmental factors, particularly epigenetic factors, can also significantly contribute to the development of inflammatory bowel disease (IBD). Although many genome-wide association studies have been performed to identify the genetic changes underlying the pathogenesis of Crohn’s disease, the role of epigenetic alteratio...
3 CitationsSource
#1Hyun Woong Kim (Inje University)H-Index: 14
#2Kug-Hwan Roh (Inje University)H-Index: 3
Last. Sae-Gwang Park (Inje University)H-Index: 23
view all 8 authors...
Background Pigment epithelium-derived factor (PEDF)–derived 34-mer peptide (PEDF34, Asp44-Asn77) has anti-angiogenic activity but has limitations in clinical application because of an inverted bell–shaped dose-effect relationship and a short half-life. In this study, we attempted to mitigate these problems by mixing PEDF34 with type I collagen.
2 CitationsSource
#1Jungik Park (Dong-eui University)H-Index: 1
#2Grace ChoiH-Index: 5
Last. Il-Whan Choi (Inje University)H-Index: 38
view all 12 authors...
: Phlorotannins (PTNs), a group of phenolic compounds from seaweeds, have diverse bioactivities. However, there has been no report on their antifibrotic effects during nasal polyp (NP) formation. In the present study, the effect of PTNs on transforming growth factor (TGF)‑β1‑induced profibrotic responses in nasal polyp‑derived fibroblasts (NPDFs) were determined and the relevant signaling pathways were investigated. The expression levels of collagen type‑1 (Col‑1) and fibronectin in NP tissues w...
1 CitationsSource
#1Mi-Jin YimH-Index: 9
#2Jeong Min LeeH-Index: 8
Last. Sun Young Ma (Kosin University)H-Index: 4
view all 11 authors...
Marine algae have valuable health and dietary benefits. The present study aimed to investigate whether an ethanol extract of Carpomitra costata (CCE) could inhibit the inflammatory response to LPS. CCE attenuated the production of proinflammatory mediators, such as prostaglandin E2 (PGE2) and nitric oxide (NO), by inhibiting inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression in LPS-induced RAW264.7 macrophages. CCE also inhibited the expression of proinflammatory cyto...
6 CitationsSource
#1Dae Sung LeeH-Index: 63
#2Chang-Min LeeH-Index: 35
Last. Il-Whan Choi (Inje University)H-Index: 38
view all 12 authors...
: Marine algae are rich sources of biologically active compounds that may present useful leads in the development of pharmaceuticals, nutraceuticals, and functional foods. The main aim of this study was to identify the possible anti-inflammatory effects of Distromium decumbens in nasal polyp-derived fibroblasts (NPDFs) and its associated mechanism of action. NPDFs were stimulated by Pseudomonas aeruginosa lipopolysaccharide (PA-LPS) and treated with an ethanolic extract of Distromium decumbens (...
#1Sun Young Ma (Kosin University)H-Index: 4
#2Jin-Hee Park (Inje University)H-Index: 4
Last. Sae-Gwang Park (Inje University)H-Index: 23
view all 14 authors...
Abstract Snail, a zinc-finger transcriptional repressor of E-cadherin expression, is one of the key inducers of epithelial-mesenchymal transition (EMT) in epithelial cancer. In breast cancer, EMT has been associated with malignancies, including metastasis, cancer stem-like properties, and resistance to chemotherapy and radiotherapy. In this study, we analysed the role of Snail in the highly metastatic mesenchymal TUBO‑P2J mouse breast cancer cells, by loss of function using short hairpin RNA. Th...
7 CitationsSource
#1Soung-Min Lee (Inje University)H-Index: 5
#2Ha Young Park (Inje University)H-Index: 1
Last. Su-Kil Seo (Inje University)H-Index: 19
view all 15 authors...
Abstract The lung is a prototypic organ that was evolved to reduce immunopathology during the immune response to potentially hazardous endogenous and exogenous antigens. In this study, we show that donor CD4+ T cells transiently induced expression of indoleamine 2,3-dioxygenase (IDO) in lung parenchyma in an IFN-γ–dependent manner early after allogeneic hematopoietic stem cell transplantation (HSCT). Abrogation of host IDO expression by deletion of the IDO gene or the IFN-γ gene in donor T cells...
25 CitationsSource
#1Chang-Min LeeH-Index: 35
#2Dae Sung LeeH-Index: 63
Last. Il-Whan Choi (Inje University)H-Index: 38
view all 12 authors...
Abstract Inflammasomes are multi-protein complexes that play a crucial role in innate immune responses. Benzyl isothiocyanate (BITC) is a naturally occurring compound found in cruciferous vegetables, and BITC exhibits potential as a chemopreventive agent. However, whether BITC exerts inflammasome-mediated regulatory effects on neuroinflammation is unknown. In this study, we examined the effects of BITC on inflammasome-mediated interleukin-1β (IL-1β) production in E. coli lipopolysaccharide (LPS)...
8 CitationsSource