Xuan Zhou
George Washington University
Regenerative medicineBiomedical engineeringNeural stem cellCellRegeneration (biology)NanotechnologyChemistryMaterials scienceMesenchymal stem cellIn vitroIn vivoLow-intensity pulsed ultrasoundStereolithography3D bioprintingChitosanStem cell3d printedChondrogenesisTissue engineeringMedicineScaffold
47Publications
22H-index
1,744Citations
Publications 46
Newest
#1Sung Yun Hann (GW: George Washington University)H-Index: 7
#2Haitao Cui (GW: George Washington University)H-Index: 27
Last. Lijie Grace ZhangH-Index: 42
view all 7 authors...
Abstract The development of sufficient vascular networks is crucial for the successful fabrication of tissue constructs for regenerative medicine, as vascularization is essential to perform the metabolic functions of tissues, such as nutrient transportation and waste removal. In recent years, efforts to 3D print vascularized bone have gained substantial attention, as bone disorders and defects have a marked impact on the older generations of society. However, conventional and previous 3D printed...
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#2Xuan Zhou (GW: George Washington University)H-Index: 22
Last. Lijie Grace ZhangH-Index: 42
view all 10 authors...
Abstract Two-dimensional (2D) in vitro cell cultures and laboratory animals have been used traditionally as the gold-standard preclinical cancer model systems. However, for cancer stem cell (CSC) studies, they exhibit notable limitations on simulating native environment, which depreciate their translatability for clinical development purposes. In this study, different three-dimensional (3D) printing platforms were used to establish novel 3D cell cultures enriched in CSCs from non-small cell lung...
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#1Xuan Zhou (GW: George Washington University)H-Index: 22
#2Margaret Nowicki (USMA: United States Military Academy)H-Index: 14
Last. Lijie Grace ZhangH-Index: 42
view all 9 authors...
Blood vessel damage resulting from trauma or diseases presents a serious risk of morbidity and mortality. Although synthetic vascular grafts have been successfully commercialized for clinical use, they are currently only readily available for large-diameter vessels (>6 mm). Small-diameter vessel (<6 mm) replacements, however, still present significant clinical challenges worldwide. The primary objective of this study is to create novel, tunable, small-diameter blood vessels with biomimetic two d...
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#1Haitao Cui (GW: George Washington University)H-Index: 27
#2Timothy Esworthy (GW: George Washington University)H-Index: 10
Last. Lijie Grace ZhangH-Index: 42
view all 7 authors...
Cancer metastases are a challenge for cancer treatment due to their organ specificity and pathophysiological complexity. Engineering 3D in vitro models capable of replicating native cancer dissemination can significantly improve the understanding of cancer biology and can help to guide the development of more effective treatments. In order to better mimic the behavior of native cancer, a triculture metastatic model is created using a stereolithography printing technique with optimized inks for i...
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#1Haitao CuiH-Index: 27
#2Timothy EsworthyH-Index: 10
Last. Lijie Grace ZhangH-Index: 42
view all 7 authors...
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#1Xuan ZhouH-Index: 22
#2Sara TenaglioH-Index: 1
Last. Lijie Grace ZhangH-Index: 42
view all 8 authors...
Cartilage damage caused by ageing, repeated overloading, trauma, and diseases can result in chronic pain, inflammation, stiffness, and even disability. Unlike other types of tissues (bone, skin, mu...
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#1Haitao Cui (GW: George Washington University)H-Index: 27
#2Chengyu Liu (NIH: National Institutes of Health)H-Index: 32
Last. Lijie Grace ZhangH-Index: 42
view all 13 authors...
There has been considerable progress in engineering cardiac scaffolds for the treatment of myocardial infarction (MI). However, it is still challenging to replicate the structural specificity and variability of cardiac tissues using traditional bioengineering approaches. In this study, a four-dimensional (4D) cardiac patch with physiological adaptability has been printed by beam-scanning stereolithography. By combining a unique 4D self-morphing capacity with expandable microstructure, the specif...
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#1Se-Jun Lee (GW: George Washington University)H-Index: 18
#2Dayun Yan (GW: George Washington University)H-Index: 17
Last. Lijie Grace ZhangH-Index: 42
view all 8 authors...
Abstract The progressive degeneration of articular cartilage or osteoarthritis of the knee is a serious clinical problem affecting patient quality of life. In recent years, artificially engineered cartilage scaffolds have been widely studied as a promising method to stimulate cartilage regeneration. In this study, a novel biomimetic cartilage scaffold was developed by integrating a cold atmospheric plasma (CAP) treatment with prolonged release of bioactive factors. Specifically, a surface of 3D ...
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#1Shida Miao (GW: George Washington University)H-Index: 23
#2Haitao Cui (GW: George Washington University)H-Index: 27
Last. Lijie Grace Zhang (GW: George Washington University)H-Index: 42
view all 9 authors...
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#1Shida Miao (GW: George Washington University)H-Index: 23
#2Haitao Cui (GW: George Washington University)H-Index: 27
Last. Lijie Grace Zhang (GW: George Washington University)H-Index: 42
view all 9 authors...
As the most versatile and promising cell source, stem cells have been studied in regenerative medicine for two decades. Currently available culturing techniques utilize a 2D or 3D microenvironment for supporting the growth and proliferation of stem cells. However, these culture systems fail to fully reflect the supportive biological environment in which stem cells reside in vivo, which contain dynamic biophysical growth cues. Herein, a 4D programmable culture substrate with a self-morphing capab...
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