Mark B. Gold
United States Army Medical Research Institute of Chemical Defense
Human decontaminationSurgeryPathologyChemistryMethemoglobinCalcium hypochloriteSodium hypochloriteHypochloriteInhalationDermisMethemoglobinemiaTopical anestheticCetacaineGuinea pigMacaqueLocal anestheticHairlessLidocaineBenzocaineSulfur mustardEpidermisHypochlorous acidFilter paperEpidermal necrosisToxicityFirst world warTime to peakBiochemical mechanismAnesthesiaMedicinePharmacology
5Publications
4H-index
66Citations
Publications 4
Newest
#1Dana R. Anderson (United States Army Medical Research Institute of Chemical Defense)H-Index: 25
#2Larry W. Mitcheltree (United States Army Medical Research Institute of Chemical Defense)H-Index: 4
Last. Mark B. Gold (United States Army Medical Research Institute of Chemical Defense)H-Index: 4
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Sulfur mustard (HD) is a vesicant compound that was first used as a chemical warfare agent in World War I. (Papirmeister et al. 1991). Numerous animal models have been used to study HD-induced vesication. In this article, we describe modifications of the vapor cup model of Mershon and colleagues (1990) to establish a new vapor cup model for use in neonatal mice. The need to develop this model resulted from the development of gene-targeted knockout mice that can be used to evaluate the function o...
4 CitationsSource
#1Dale G. Martin (United States Army Medical Research Institute of Chemical Defense)H-Index: 1
#2Charles E. WatsonH-Index: 2
Last. Steven I. Baskin (United States Army Medical Research Institute of Chemical Defense)H-Index: 17
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Benzocaine (BNZ) and lidocaine (LC) are commonly used topical (spray) anesthetics approved for use in humans. Benzocaine has structural similarities to methemoglobin (MHb)-forming drugs that are current candidates for cyanide prophylaxis, while LC has been reported to increase MHb in man. In this study, we compared MHb and sulfhemoglobin (SHb) production in three groups of Macaques (Chinese rhesus and Indian rhesus (Macaca mulatta) and pig-tailed macaques (Macaca nemestrina)) after exposure to B...
19 CitationsSource
#1Mark B. Gold (United States Army Medical Research Institute of Chemical Defense)H-Index: 4
#2Rodolfo Bongiovanni (United States Army Medical Research Institute of Chemical Defense)H-Index: 2
Last. Claude L. Woodward (United States Army Medical Research Institute of Chemical Defense)H-Index: 1
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ABSTRACTHypochlorite solutions are thought to be efficacious when used to topically decontaminate intact skin. However, few studies have examined the efficacy of decontamination of chemically contaminated wounds. Therefore, we compared the decontamination efficacy of sodium hypochlorite (0.5% and 2.5% solutions), calcium hypochlorite (0.5% and 2.5% solutions) and sterile water to untreated controls in wounds exposed to sulfur mustard (HD). Anesthetized euthymic hairless guinea pigs (EHGP) (n=6) ...
26 CitationsSource
#1Dale G. MartinH-Index: 4
#2Claude L. WoodardH-Index: 3
Last. Steven I. BaskinH-Index: 17
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Benzocaine (BNZ) and lidocaine (LC) are commonly used topical (spray) anesthetics approved for use in humans. BNZ has structural similarities to methemoglobin (MHb) forming drugs that are current candidates for cyanide prophylaxis, while LC has been reported to increase MHb in man. We therefore, compared MHb and sulfhemoglobin (SHb) production in three groups of Macaques (Macaca mulata, Chinese rhesus and Indian rhesus, and Macaca nemistrina, Pig-tailed Macaques) after exposure to BNZ and LC. Fo...
2 Citations