Christoph Lichy
University of Basel
DissectionInternal medicineGenotypeSurgeryPathologyCase-control studyOdds ratioCardiologyPhysical therapyImmunologyYoung adultVertebral artery dissectionVascular diseasePopulationCervical ArteryRisk factorStrokeIschemiaMedicineGastroenterology
Publications 76
#1Dorothea Pfeiffer (University Hospital Heidelberg)H-Index: 1
#1Dorothea Pfeiffer (University Hospital Heidelberg)H-Index: 17
Last. Arne LindgrenH-Index: 58
view all 45 authors...
Background and Purpose— We sought to explore the effect of genetic imbalance on functional outcome after ischemic stroke (IS). Methods— Copy number variation was identified in high-density single-nucleotide polymorphism microarray data of IS patients from the CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) and SiGN (Stroke Genetics Network)/GISCOME (Genetics of Ischaemic Stroke Functional Outcome) networks. Genetic imbalance, defined as total number of protein-coding genes affec...
8 CitationsSource
#1Annette Compter (NKI-AVL: Netherlands Cancer Institute)H-Index: 6
#2Sabrina SchillingH-Index: 11
Last. Stéphanie DebetteH-Index: 61
view all 33 authors...
Objective To assess putative risk factors and outcome of multiple and early recurrent cervical artery dissection (CeAD). Methods We combined data from 2 multicenter cohorts and compared patients with multiple CeAD at initial diagnosis, early recurrent CeAD within 3 to 6 months, and single nonrecurrent CeAD. Putative risk factors, clinical characteristics, functional outcome, and risk of recurrent ischemic events were assessed. Results Of 1,958 patients with CeAD (mean ± SD age 44.3 ± 10 years, 4...
14 CitationsSource
#1Caspar Grond-Ginsbach (Heidelberg University)H-Index: 33
#2Bowang Chen (SUSTech: South University of Science and Technology of China)H-Index: 3
Last. Stefan T. Engelter (University of Basel)H-Index: 72
view all 31 authors...
Background: Genetic and environmental risk factors are assumed to contribute to the susceptibility to cervical artery dissection (CeAD). To explore the role of genetic imbalance in the etiology of CeAD, copy number variants (CNVs) were identified in high-density microarrays samples from the multicenter CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) study and from control subjects from the CADISP study and the German PopGen biobank. Microarray data from 833 CeAD patients and 204...
17 CitationsSource
#1Christoph LichyH-Index: 31
#2Antti J. Metso (HYKS: Helsinki University Central Hospital)H-Index: 22
Last. Caspar Grond-Ginsbach (Heidelberg University)H-Index: 33
view all 23 authors...
Stroke in patients with acute cervical artery dissection may be anticipated by initial transient ischemic or nonischemic symptoms. Identifying risk factors for delayed stroke upon cervical artery dissection. Cervical artery dissection patients from the multicenter Cervical Artery Dissection and Ischemic Stroke Patients study were classified as patients without stroke (n = 339), with stroke preceded by nonstroke symptoms (delayed stroke, n = 244), and with stroke at onset (n = 382). Demographics,...
23 CitationsSource
#1Stéphanie Debette (University of Bordeaux)H-Index: 61
#2Yoichiro KamataniH-Index: 49
Last. Jean Dallongeville (Lille University of Science and Technology)H-Index: 78
view all 68 authors...
Cervical artery dissection (CeAD), a mural hematoma in a carotid or vertebral artery, is a major cause of ischemic stroke in young adults although relatively uncommon in the general population (incidence of 2.6/100,000 per year). Minor cervical traumas, infection, migraine and hypertension are putative risk factors, and inverse associations with obesity and hypercholesterolemia are described. No confirmed genetic susceptibility factors have been identified using candidate gene approaches. We per...
129 CitationsSource
#1Caspar Grond-Ginsbach (University Hospital Heidelberg)H-Index: 33
#2Christoph LichyH-Index: 31
Last. Stefan T. EngelterH-Index: 72
view all 9 authors...
4 CitationsSource
#1Stéphanie Debette (University of Bordeaux)H-Index: 61
#2Barbara Goeggel Simonetti (University of Bern)H-Index: 13
Last. Marcel ArnoldH-Index: 76
view all 41 authors...
In a large series of patients with cervical artery dissection (CeAD), a major cause of ischemic stroke in young and middle-aged adults, we aimed to examine frequencies and correlates of family history of CeAD and of inherited connective tissue disorders. We combined data from 2 large international multicenter cohorts of consecutive patients with CeAD in 23 neurologic departments participating in the CADISP-plus consortium, following a standardized protocol. Frequency of reported family history o...
45 CitationsSource
#1Kaja Tikk (Heidelberg University)H-Index: 1
#1Kaja Tikk (DKFZ: German Cancer Research Center)H-Index: 11
Last. Rudolf KaaksH-Index: 151
view all 7 authors...
Background and Purpose— Because primary prevention of stroke is a priority, our aim was to assess the primary preventive potential of major lifestyle risk factors for stroke in middle-aged women and men. Methods— Among 23 927 persons, 551 (195 women and 356 men) had a first diagnosis of stroke during an average follow-up of 12.7 years. Using Cox proportional hazards models, we estimated the associations of adiposity, smoking, physical activity, alcohol consumption, and diet with risk of developi...
35 CitationsSource
#1Philippe Lyrer (University of Basel)H-Index: 57
#2Tobias BrandtH-Index: 31
Last. Caspar Grond-Ginsbach (Heidelberg University)H-Index: 33
view all 19 authors...
Objective: To study the prognostic importance of Horner syndrome (HS) in patients with internal carotid artery dissection (ICAD) or vertebral artery dissection (VAD). Methods: In this observational study, characteristics and outcome of patients with ICAD or VAD from the CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) database were analyzed. The presence of HS was systematically assessed using a standardized questionnaire. Patients with HS (HS+) were compared with HS− patients. C...
27 CitationsSource
#1N. Yesilot Barlas (Istanbul University)H-Index: 1
#2Jukka Putaala (HYKS: Helsinki University Central Hospital)H-Index: 39
Last. S. Bahar (Istanbul University)H-Index: 18
view all 42 authors...
BACKGROUND AND PURPOSE: Risk factors for IS in young adults differ between genders and evolve with age, but data on the age- and gender-specific differences by stroke etiology are scare. These features were compared based on individual patient data from 15 European stroke centers. METHODS: Stroke etiology was reported in detail for 3331 patients aged 15-49 years with first-ever IS according to Trial of Org in Acute Stroke Treatment (TOAST) criteria: large-artery atherosclerosis (LAA), cardioembo...
105 CitationsSource