Masaaki Nakayama
Tohoku University
Internal medicineUrologyEndocrinologySurgeryPathologyRenal functionIntensive care medicineOxidative stressHemodialysisMethylglyoxalKidney diseasePeritoneal dialysisRenal replacement therapyDialysisCreatinineContinuous ambulatory peritoneal dialysisIn patientNephrologyDiabetes mellitusMedicineBlood pressureGastroenterology
261Publications
41H-index
6,764Citations
Publications 264
Newest
#1Hidehisa SattaH-Index: 1
#2Tamio IwamotoH-Index: 13
Last. Masaaki Nakayama (Tohoku University)H-Index: 41
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A novel hemodialysis (HD) system employing electrolyzed water containing molecular hydrogen (E-HD) has been developed to improve the bio-compatibility of HD. This study examined the impact of E-HD on changes in redox state during HD and HD-related fatigue. This single-arm, prospective observational study examined 63 patients on chronic HD (41 males; mean age, 72 ± 9 years; median duration of HD, 7 years). Redox parameters (serum myeloperoxidase [MPO], malondialdehyde-protein adduct [MDA-a], thio...
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#1Kimio WatanabeH-Index: 12
Last. Masaaki NakayamaH-Index: 41
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Renin-angiotensin-aldosterone system (RAAS) is primarily involved with pathological mechanism of developing hypertensive emergencies. However, none of clinical practice guidelines mention RAAS blockers for the treatment of hypertensive emergencies. A 44 year-old woman presented with severe hypertension, brain stem posterior reversible encephalopathy syndrome and severe acute kidney injury (AKI). We started anti-hypertensive therapy with continuous intravenous nitroglycerin and oral calcium chann...
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#1Takuya FujimaruH-Index: 3
#2Takuya Shuo (Hokuriku University)
Last. Yasuhiro Komatsu (Gunma University)H-Index: 13
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Acidemia is one of the risk factors for end-stage kidney disease and increases the mortality rate of patients with chronic kidney disease (CKD). Although urinary ammonium (U-NH4+ ) is the crucial component of renal acid excretion, U-NH4+ concentration is not routinely measured. To estimate U-NH4+ , urine osmolal gap (UOG = urine osmolality - [2(Na+ + K+ ) + urea + glucose]) is calculated and the formula (U-NH4+ = UOG/2) has traditionally been used. However, the usefulness of this formula is cont...
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#1Yasuhiko Ito (Aichi Medical University)H-Index: 28
#2Munekazu RyuzakiH-Index: 15
Last. Noritomo ItamiH-Index: 21
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Approximately 10 years have passed since the Peritoneal Dialysis Guidelines were formulated in 2009. Much evidence has been reported during the succeeding years, which were not taken into consideration in the previous guidelines, e.g., the next peritoneal dialysis PD trial of encapsulating peritoneal sclerosis (EPS) in Japan, the significance of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), the effects of icodextrin solution, new developments in perit...
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#1Yasutoshi Akiyama (Tohoku University)H-Index: 18
#2Koichi Kikuchi (Tohoku University)H-Index: 13
Last. Takaaki Abe (Tohoku University)H-Index: 58
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Uremic toxins are suggested to be involved in the pathophysiology of hemodialysis (HD) patients. However, the profile of uremic solutes in HD patients has not been fully elucidated. In this study using capillary electrophoresis mass spectrometry (CE-MS), we comprehensively quantified the serum concentrations of 122 ionic solutes before and after HD in 11 patients. In addition, we compared the results with those in non-HD patients with chronic kidney disease (CKD) to identify HD patient-specific ...
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#1Philip Kam-Tao Li (CUHK: The Chinese University of Hong Kong)H-Index: 79
#2Agnes Shin-Man Choy (CUHK: The Chinese University of Hong Kong)H-Index: 4
Last. Xueqing Yu (Peking Union Medical College)
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Anemia is an important complication in patients with chronic kidney disease. Peritoneal dialysis (PD) is one of the most common modalities of kidney replacement therapy for patients with end-stage kidney disease. PD is particularly prevalent in the Asian Pacific region. Among the different countries and regions, including mainland China, Hong Kong, Japan, Malaysia, Singapore, South Korea, and Thailand, PD accounts for 2.8% to 74.6% of the dialysis population. In addition, 82% to 96% of the PD po...
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#1Kimio WatanabeH-Index: 12
#2Masaaki Nakayama (Tohoku University)H-Index: 41
Last. Sadayoshi Ito (Tohoku University)H-Index: 90
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BACKGROUND Hyperuricemia is highly prevalent in chronic kidney disease (CKD) patients, but the evidence for a relationship between uric acid (UA) and clinical outcomes in CKD patients is limited and inconsistent. We hypothesized that UA has a different impact on clinical outcomes according to the underlying disease causing CKD. METHODS This study prospectively investigated the associations between UA and renal and non-renal outcomes according to the underlying disease causing CKD in 2,797 Japane...
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#1Kimio WatanabeH-Index: 12
#2Yugo ItoH-Index: 2
Last. Masaaki NakayamaH-Index: 41
view all 6 authors...
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#1Yukio Maruyama (Jikei University School of Medicine)H-Index: 18
#2Masaaki NakayamaH-Index: 41
Last. Takashi Yokoo (Jikei University School of Medicine)H-Index: 28
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Background Fatigue is one of the most frequent complications in dialyzed patients and is associated with poorer patient outcomes. Multiple factors are reported to be associated with fatigue development. Of them, the impacts of dialysis modalities remain unknown. Methods A total of 194 dialysis patients (mean age, 61±11 years; 134 males; modalities included hemodialysis (HD) in 26, online hemodiafiltration (HDF) in 74, peritoneal dialysis (PD) in 68, and combined therapy with PD and HD in 26 case...
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#1Kimio WatanabeH-Index: 12
#2Emiko SatoH-Index: 15
Last. Masaaki Nakayama (Fukushima Medical University)H-Index: 41
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One third of the patients with chronic kidney disease (CKD) develop cognitive impairment, which is also an independent risk factor for mortality. However, the concise mechanism of cerebro-renal interaction has not been clarified. The present study examines the effects of uremic toxins on neuronal cells and analyzes the pathological condition of the brain using mouse hippocampal neuronal HT-22 cells and adenine-induced CKD model rats. Among the uremic toxins analyzed, indoxyl sulfate, indole, 3-i...
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