Nicholas E Burr
Leeds Teaching Hospitals NHS Trust
EpidemiologyInternal medicineEtiologySurgeryRandomized controlled trialAdverse effectPlaceboAspirinInflammatory bowel diseaseColonoscopyEndoscopyMEDLINEConstipationPopulationOpioid induced constipationIncidence (epidemiology)Colorectal cancerGeneral surgeryMedicineRelative riskGastroenterologyMeta-analysis
61Publications
14H-index
751Citations
Publications 49
Newest
#1Simon M Everett (St James's University Hospital)H-Index: 15
#1Simon EverettH-Index: 8
Last. Nicholas E BurrH-Index: 14
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Colorectal cancer (CRC) is the third most common malignancy in men and women in England and the second most common cause of cancer-related death. The English bowel cancer screening programme (BCSP) was introduced for those aged 60–69 years in 2006, with rollout complete for 74-year-olds in 2014 and a predicted reduction in CRC mortality of 16% based on the first 2 million tests offered.1 The number of BCSP colonoscopies has increased by nearly a third from 2017 to 2019, and this trend is set to ...
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#1Nicholas E Burr (Leeds Teaching Hospitals NHS Trust)H-Index: 14
#2Andrew Plumb (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 2
Last. Damian Tolan (Leeds Teaching Hospitals NHS Trust)H-Index: 18
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We read with interest the recent article by Cash et al comparing colon capsule (CCE) and CT colonography (CTC) with optical colonoscopy (OC) for detecting colonic polyps and colorectal cancer (CRC) in a screening population.1 The study reports low CTC detection rates for ≥6 mm and ≥10 mm polyps of only 8.6% and 6.3%, respectively. These were much lower than the detection rates seen for CCE and OC. These results contradict larger trials, where the performance of CTC and OC tests are similar. The ...
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#1Ryckie G. Wade (University of Leeds)H-Index: 12
#2Timothy T. Griffiths (University of Leeds)H-Index: 1
Last. Grainne Bourke (University of Leeds)H-Index: 5
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Importance Cubital tunnel syndrome is the second most common compressive neuropathy, affecting 6% of the population. Numerous different operations are performed globally to treat it; however, prior conventional (pairwise) meta-analyses have been unable to determine which procedure is associated with the best outcomes and fewest complications. Objective To evaluate which operation for cubital tunnel syndrome is associated with the greatest likelihood of symptomatic cure. Data Sources PubMed, EMBA...
1 CitationsSource
#1Ryckie G. WadeH-Index: 12
#2Nicholas E Burr (University of Leeds)H-Index: 14
Last. Orestis Efthimiou (University of Bern)H-Index: 19
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Objective: There is uncertainty around preoperative skin antisepsis in clean surgery. Network meta-analysis provides more precise estimates than standard pairwise meta-analysis and can rank interventions by efficacy, to better inform clinical decisions. Background: Infection is the most common and costly complication of surgery. The relative efficacy of CHG and PVI based skin antiseptics in clean surgery remains unclear. Methods: We searched for randomized or nonrandomized studies comparing the ...
3 CitationsSource
#1Nicholas E Burr (University of Hull)H-Index: 14
#2Christopher J Black (St James's University Hospital)H-Index: 13
The world is suffering from a pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 or COVID-19), with a mortality rate of up to 4%.1 COVID-19 infection is seen at disproportionately high levels among healthcare workers. Current UK guidance regarding the use of personal protective equipment (PPE) for COVID-19 was updated in April 2020.2 For close contact (<2 metres), the recommended respiratory protection remains a fluid-resistant surgical face mask. However, for areas at highe...
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#1Christopher J Black (University of Leeds)H-Index: 13
#2Nicholas E Burr (University of Leeds)H-Index: 14
Last. Alexander C. Ford (University of Leeds)H-Index: 86
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: Irritable bowel syndrome (IBS) is a chronic functional bowel disorder affecting 1 in 10 people and associated with poor psychological health, reduced quality of life, and increased health care expenditure.1 The etiology is complex and incompletely understood.2 Approximately one-third of patients have IBS with constipation (IBS-C),1 for which there are licensed therapies available in the United States. We summarized comparative efficacy of these in a recent network meta-analysis of randomized c...
18 CitationsSource
#1Rebecca Anderson (Gloucestershire Hospitals NHS Foundation Trust)H-Index: 2
#2Nicholas E Burr (University of Leeds)H-Index: 14
Last. Roland Valori (Gloucestershire Hospitals NHS Foundation Trust)H-Index: 32
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Abstract Background & Aims Post-colonoscopy colorectal cancer (PCCRC) is CRC diagnosed after a colonoscopy in which no cancer was found. A consensus article from the World Endoscopy Organization (WEO) proposed an approach for investigating and categorizing PCCRCs detected within 4 years of a colonoscopy. We aimed to identify cases of PCCRC and the factors that cause them, test the WEO system of categorization, quantify the proportion of avoidable PCCRCs, and propose a target rate for PCCRCs dete...
16 CitationsSource
#1Pavit Luthra (Royal Free Hospital)H-Index: 1
#2Michael Camilleri (Mayo Clinic)H-Index: 146
Last. Alexander C. Ford (St James's University Hospital)H-Index: 86
view all 6 authors...
Source
#1Christopher J Black (University of Leeds)H-Index: 13
#2Nicholas E Burr (University of Leeds)H-Index: 14
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 8 authors...
Objective Over half of patients with IBS have either diarrhoea (IBS-D) or a mixed stool pattern (IBS-M). The relative efficacy of licenced pharmacological therapies is unclear in the absence of head-to-head trials. We conducted a network meta-analysis to resolve this uncertainty. Design We searched MEDLINE, Embase, Embase Classic, the Cochrane central register of controlled trials, and Clinicaltrials.gov through January 2019 to identify randomised controlled trials (RCTs) assessing the efficacy ...
31 CitationsSource
#1Nicholas E Burr (University of Leeds)H-Index: 14
#2Edmund Derbyshire (Royal Liverpool and Broadgreen University Hospital NHS Trust)H-Index: 1
Last. Eva Morris (University of Leeds)H-Index: 29
view all 9 authors...
Abstract Objectives To quantify post-colonoscopy colorectal cancer (PCCRC) rates in England by using recent World Endoscopy Organisation guidelines, compare incidence among colonoscopy providers, and explore associated factors that could benefit from quality improvement initiatives. Design Population based cohort study. Setting National Health Service in England between 2005 and 2013. Population All people undergoing colonoscopy and subsequently diagnosed as having colorectal cancer up to three ...
26 CitationsSource