Tom R. Kurzawinski
University College London
Internal medicineRadiologyEndocrinologySurgeryPathologyRetrospective cohort studyPediatricsPositron emission tomographyHyperparathyroidismThyroidectomyParathyroidectomyPrimary hyperparathyroidismMalignancyAdrenalectomyMultiple endocrine neoplasiaPapillary thyroid cancerNuclear medicineThyroid carcinomaProphylactic thyroidectomyThyroidMedicineGastroenterology
49Publications
10H-index
426Citations
Publications 49
Newest
#2Hassan NounouH-Index: 1
Last. Tom R. KurzawinskiH-Index: 10
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#1Kerstin Sander (UCL: University College London)H-Index: 9
#2Thibault Gendron (UCL: University College London)H-Index: 7
Last. Bryan Williams (UCL: University College London)H-Index: 149
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The purpose of this study was to synthesize a fluorine-18 labeled, highly selective aldosterone synthase (hCYP11B2) inhibitor, [18F]AldoView, and to assess its potential for the detection of aldosterone-producing adenomas (APAs) with positron emission tomography in patients with primary hyperaldosteronism (PHA). Using dibenzothiophene sulfonium salt chemistry, [18F]AldoView was obtained in high radiochemical yield in one step from [18F]fluoride. In mice, the tracer showed a favorable pharmacokin...
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#1Vinaya Srirangam Nadhamuni (QMUL: Queen Mary University of London)H-Index: 2
#2Donato Iacovazzo (QMUL: Queen Mary University of London)H-Index: 13
Last. Satya Bhattacharya (St Bartholomew's Hospital)
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Summary A male patient with a germline mutation in MEN1 presented at the age of 18 with classical features of gigantism. Previously, he had undergone resection of an insulin-secreting pancreatic neuroendocrine tumour (pNET) at the age of 10 years and had subtotal parathyroidectomy due to primary hyperparathyroidism at the age of 15 years. He was found to have significantly elevated serum IGF-1, GH, GHRH and calcitonin levels. Pituitary MRI showed an overall bulky gland with a 3 mm hypoechoic are...
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#1Daniel Moffat (QMUL: Queen Mary University of London)
#2Polly Richards (QMUL: Queen Mary University of London)H-Index: 3
Last. Ashley Grossman (Green Templeton College)H-Index: 10
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Scanning for somatostatin receptors using 68 Ga-dotatate positron emission tomography with co-registration with computed tomography or magnetic resonance imaging is now in widespread use for the identification of neuroendocrine tumours, phaeochromocytomas, and paragangliomas and their metastases. We present a case where a patient with a phaeochromocytoma showed uptake in her neck considered diagnostic of a head-and-neck paraganglioma, which was subsequently confirmed to be a metastatic papillary...
1 CitationsSource
#1Mechteld C. de Jong (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 1
#2Mark N. Gaze (GOSH: Great Ormond Street Hospital)H-Index: 28
Last. Tom R. Kurzawinski (UCLH: University College London Hospitals NHS Foundation Trust)H-Index: 10
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AIM Differentiated thyroid cancer (DTC) in children and adolescents is rare and data about its presentation and management are not well known. The aim of this study was to provide evidence of the current practice in the United Kingdom before the launch of the Rare National Paediatric Endocrine Tumours Guidelines (to be published in 2020). METHODS Seventy-two children and adolescents with DTC (<18 years) who were treated at our institution between 2003 and 2018 were identified and their presentat...
4 CitationsSource
#2Polly RichardsH-Index: 3
Last. Ashley GrossmanH-Index: 3
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#1Mechteld C de Jong (UCLH: University College Hospital)H-Index: 1
#2Hassan Nounou (UCLH: University College Hospital)H-Index: 1
Last. Tom R. Kurzawinski (UCLH: University College Hospital)H-Index: 10
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Abstract Purpose Disruption of calcium homeostasis is the most common complication after total thyroidectomy in adults. We explored the incidence and risk factors of hypocalcaemia and hypoparathyroidism after total thyroidectomy in children(≤ 18 years of age). Methods One-hundred-and-six children underwent a total thyroidectomy. Patient, operative and outcome data were collected and analyzed. Results The indication for surgery was Graves' disease in 52 children(49.1%), Multiple Endocrine Neoplas...
12 CitationsSource
#1Mechteld C de Jong (UCLH: University College Hospital)H-Index: 1
#2Karim Jamal (UCLH: University College Hospital)
Last. Tom R. Kurzawinski (UCLH: University College Hospital)H-Index: 10
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BACKGROUND: The success of minimally invasive parathyroidectomy (MIP) relies on accurate localization of the abnormal parathyroid glands. Concordant findings on ultrasound (US) and 99mTc-scintigraphy (sestamibi) are currently considered the 'gold standard'. Computed tomography (CT) has also recently been used in preoperative planning. We sought to assess the accuracy of CT for localization of abnormal parathyroid glands in such patients. METHODS: An audit of 75 patients with primary hyperparathy...
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#1Michael S. Shawky (Alexandria University)H-Index: 7
#2Ian Proctor (UCLH: University College Hospital)H-Index: 10
Last. Tarek Ezzat Abdel-Aziz (Alexandria University)H-Index: 3
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The brain is a particularly rare site of metastasis from papillary microcarcinoma, with only few cases described in the literature. We present a case of 59-year-old man who presented with seizures ...
1 CitationsSource
#1Michael S. Shawky (Alexandria University)H-Index: 7
#2Mahmoud Sakr (Alexandria University)H-Index: 12
Last. Tom R. Kurzawinski (UCLH: University College Hospital)H-Index: 10
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Intraoperative monitoring of parathyroid hormone (IOPTH) is a reliable method of predicting the cure of primary hyperparathyroidism (PHPT). The aim of this study is to assess whether common clinical variables (CCV) frequently encountered in patients with PHPT may affect the magnitude of PTH drop or the likelihood of patients meeting the intraoperative cure criterion. Patients who were surgically cured from PHPT caused by single gland disease (SGD) and had full IOPTH protocol (4 measurements) wer...
1 CitationsSource