Bryan Williams
National Institute for Health Research
Internal medicineEndocrinologySurgeryCardiologyIntensive care medicineDiabetes mellitusMedicineBlood pressureBiology
Publications 534
#1Monique E. A. M. van Kleef (UU: Utrecht University)H-Index: 3
#2Karsten Heusser (DLR: German Aerospace Center)H-Index: 26
Last. Wilko Spiering (UU: Utrecht University)H-Index: 32
view all 9 authors...
Background null First in human studies suggest that endovascular baroreflex amplification (EVBA) lowers blood pressure (BP). To explore potential mechanisms for BP reduction, this study examines the effects of EVBA on muscle sympathetic nerve activity (MSNA) and baroreceptor sensitivity (BRS). null Methods null In a single-center sub-study of the CALM-DIEM study (Controlling And Lowering blood pressure with the MobiusHD-Defining Efficacy Markers), 14 patients with resistant hypertension were tre...
#1Paweł KrzemieńH-Index: 1
#2Sławomir Kasperczyk (Medical University of Silesia)H-Index: 24
Last. Lipidogram InvestigatorsH-Index: 2
view all 22 authors...
The detection of antinuclear autoantibody (ANA) is dependent on many factors and varies between the populations. The aim of the study was first to assess the prevalence of ANA in the Polish adult population depending on age, sex and the cutoff threshold used for the results obtained. Second, we estimated the occurrence of individual types of ANA-staining patterns. We tested 1731 patient samples using commercially available IIFA using two cutoff thresholds of 1:100 and 1:160. We found ANA in 260 ...
#1D Lane (Leicester Royal Infirmary)H-Index: 3
Last. Indranil Dasgupta (Warw.: University of Warwick)H-Index: 30
view all 17 authors...
Nonadherence to antihypertensive medication is common, especially in those with apparent treatment-resistant hypertension (true treatment-resistant hypertension requires exclusion of nonadherence), and its routine detection is supported by clinical guidelines. Chemical adherence testing is a reliable and valid method to detect adherence, yet methods are unstandardized and are not ubiquitous. This article describes the principles of chemical adherence testing for hypertensive patients and provide...
#1Göran Tornling (KI: Karolinska Institutet)H-Index: 23
#2Rohit BattaH-Index: 1
Last. Kate WestergaardH-Index: 1
view all 12 authors...
Background null COVID-19 morbidity and mortality remains high and the need for safe and effective drugs continues despite vaccines. null Methods null Double-blind, placebo-controlled, multi-centre, randomised, parallel group phase 2 trial to evaluate safety and efficacy of oral angiotensin II type 2 receptor agonist C21 in hospitalized patients with COVID-19 and CRP ≥ 50-150 mg/L conducted at eight sites in India (NCT04452435). Patients were randomly assigned 100 mg C21 bid or placebo for 7 days...
The aim of this study was to assess the blood pressure (BP) measurement accuracy of the Kinetik Blood Pressure Monitor-Series 1 (BPM-1) for use in home or clinical settings according to the 2002 European Society of Hypertension International Protocol (ESH-IP). Forty-two participants were recruited to fulfil the required number of systolic and diastolic BP measurements according to the ESH-IP. Nine sequential same-arm BP readings were measured and analysed for each participant using the test devi...
#1Kazuomi Kario (Jichi Medical University)H-Index: 2
#2Naoko Tomitani (Jichi Medical University)H-Index: 15
Last. Bryan Williams (UCL: University College London)H-Index: 90
view all 6 authors...
This study sought to evaluate the relationship between blood pressure (BP) taken by a new wrist-cuff oscillometric wearable BP monitoring device and left ventricular mass index measured by cardiac magnetic resonance imaging (cMRI-LVMI) in 50 hypertensive patients (mean age 60.5 ± 8.9 years, 92.0% men, 96% treated for hypertension) with regular employment. Participants were asked to self-measure their wearable BPs twice in the morning and evening under a guideline-recommended standardized home BP...
#1Amy NelsonH-Index: 1
#2Robert GrayH-Index: 1
Last. Parashkev NachevH-Index: 29
view all 13 authors...
The value of biomedical research--a $1.7 trillion annual investment--is ultimately determined by its downstream, real-world impact. Current objective predictors of impact rest on proxy, reductive metrics of dissemination, such as paper citation rates, whose relation to real-world translation remains unquantified. Here we sought to determine the comparative predictability of future real-world translation--as indexed by inclusion in patents, guidelines or policy documents--from complex models of t...
#1Alvina G. Lai (UCL: University College London)H-Index: 17
#2Wai Hoong Chang (UCL: University College London)H-Index: 4
Last. Tom R. Gaunt (UoB: University of Bristol)H-Index: 70
view all 29 authors...
BACKGROUND An Informatics Consult has been proposed in which clinicians request novel evidence from large scale health data resources, tailored to the treatment of a specific patient. However, the availability of such consultations is lacking. We seek to provide an Informatics Consult for a situation where a treatment indication and contraindication coexist in the same patient, i.e., anti-coagulation use for stroke prevention in a patient with both atrial fibrillation (AF) and liver cirrhosis. M...
#1Rachael A. Evans (University of Leicester)H-Index: 15
#2Hamish Mcauley (University of Leicester)H-Index: 3
Last. Olivia C. Leavy (University of Leicester)H-Index: 5
view all 53 authors...
Summary null null Background null The impact of COVID-19 on physical and mental health and employment after hospitalisation with acute disease is not well understood. The aim of this study was to determine the effects of COVID-19-related hospitalisation on health and employment, to identify factors associated with recovery, and to describe recovery phenotypes. null null null Methods null The Post-hospitalisation COVID-19 study (PHOSP-COVID) is a multicentre, long-term follow-up study of adults (...
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