Tsutomu Kobayashi
Harbin Medical University
AirwayInternal medicineBreathingEndocrinologyWorld Wide WebFunction (biology)PathologyAntigenMolecular biologyLibrary scienceProteasesChemistryImmunologyIncubationLung volumesRespiratory diseasePhospholipase A2ProteasePentobarbitalRespiratory failureTidal volumeLungTerminal (electronics)Bronchoalveolar lavageCytokineGuinea pigPresumptionMeconium aspiration syndromeMeconiumSurfactant replacementImmature lungsLung injuryHigh resolutionEarly analysisComputer scienceAnesthesiaBiochemistryPulmonary surfactantMedicineInterleukin
Publications 7
#1Katsumi TashiroH-Index: 8
#2Yongmei XuH-Index: 2
Last. Chiharu KabataH-Index: 3
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#1Yasuhiro SuzukiH-Index: 2
#2Tsutomu KobayashiH-Index: 2
Last. Shigeo OhmuraH-Index: 10
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You might find this additional info useful...This article cites€30 articles, 13 of which you can access for free at: http://jap.physiology.org/content/83/6/1849.full#ref-list-1This article has been cited by€4 other HighWire-hosted articles: http://jap.physiology.org/content/83/6/1849#cited-by Updated information and services including high resolution figures, can be found at: http://jap.physiology.org/content/83/6/1849.fullAdditional material and information about Journal of Applied Physiology c...
#1Tsutomu KobayashiH-Index: 2
#2Hailing WuH-Index: 1
Last. Wen-Zhi LiH-Index: 2
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#1H. Wu (HMU: Harbin Medical University)H-Index: 1
#2Tsutomu Kobayashi (HMU: Harbin Medical University)H-Index: 2
Last. Wenzhi Li (HMU: Harbin Medical University)H-Index: 6
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Background: Overdistension of the lung causes ventilator-induced lung injury (VILI) accompanied by surfactant abnormalities and inflammatory changes. We investigated the effects of surfactant replacement on overdistension of the terminal airspaces and plasma cytokine levels in VILI. Methods: VILI was induced by high-pressure ventilation (HPV) in rats anesthetized with pentobarbital, followed by ventilation for 2 h in the maintenance mode (tidal volume=10 ml/kg, positive end-expiratory pressure=7...
4 CitationsSource
#1Tsutomu Kobayashi (HMU: Harbin Medical University)H-Index: 2
#2Hailing Wu (HMU: Harbin Medical University)H-Index: 1
Last. Katsumi TashiroH-Index: 8
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Background: Overdistension of the lungs is a cause of ventilator-induced lung injury. In meconium aspiration syndrome, irregular overdistension of the lungs often occurs. Objectives: We investigated whether surfactant replacement could restore the terminal airspaces in the lungs that had been distended after meconium aspiration. Methods: Meconium aspiration was induced by injecting meconium (50 mg·kg–1) into the airways of adult rats anesthetized with pentobarbital and ventilated with pressure-p...
2 CitationsSource
#1Miki AboH-Index: 14
#2Kazuyoshi KurashimaH-Index: 21
Last. Tsutomu Kobayashi (Kanazawa University)H-Index: 2
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Background and objective: Surfactant dysfunction is a characteristic of bronchial asthma, but mechanisms of dysfunction following antigen exposure are not understood. The aim of this study was to examine whether bronchoalveolar lavage fluid (BALF) has surfactant degradation activity after antigen challenge, using an animal model of asthma. Methods: BALF was collected 24 h after a challenge with aerosolized antigen solution in actively sensitized guinea pigs and from non-sensitized control guinea...
#1Katsumi TashiroH-Index: 8
#2Wen-Zhi LiH-Index: 2
Last. Tsutomu KobayashiH-Index: 2
view all 6 authors...
1 CitationsSource