Elina Arakelova
Armenian National Academy of Sciences
IrradiationComplement systemInternal medicineEndocrinologyAntibodyChemistryImmunologySuperoxide dismutaseOxidative stressSchiff baseBlood plasmaAntioxidantBrain ischemiaCatalaseLipid peroxidationHealthy subjectsIschemic strokeStrokeViability assayBiochemistryDiabetes mellitusMedicineImmune systemPharmacology
13Publications
5H-index
19Citations
Publications 21
Newest
African swine fever virus (ASFV) is the causal agent of a highly fatal disease of domestic swine for which no effective vaccines and antiviral drugs are available. Recently, it has been shown that microtubule-targeting agents hamper the infection cycle of different viruses, raising the idea that microtubules can be potential host targets for antiviral drug development. In this study, we conducted in silico screening against the colchicine binding site (CBS) of tubulin and found three new compoun...
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The development of new laser-driven electron linear accelerators, providing unique ultrashort pulsed electron beams (UPEBs) with low repetition rates, opens new opportunities for radiotherapy and new fronts for radiobiological research in general. Considering the growing interest in the application of UPEBs in radiation biology and medicine, the aim of this study was to reveal the changes in immune system in response to low-energy laser-driven UPEB whole-body irradiation in rodents. Forty male a...
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#1Gohar Tsakanova (Armenian National Academy of Sciences)H-Index: 6
#2Elina Arakelova (Armenian National Academy of Sciences)H-Index: 5
Last. Nelly Babayan (Armenian National Academy of Sciences)H-Index: 6
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Purpose null To describe the contribution of women scientists in the development of biomedical studies conducted on research facilities based on the ultrashort pulsed laser technologies in Armenia. null Conclusion null Given the opportunities provided by the ultrashort pulsed laser driven two-photon microscopy and electron beam linac facilities at CANDLE Synchrotron Research Institute, the Armenian women scientists initiated and conducted interdisciplinary research to understand of the biomedica...
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PURPOSE To describe the contribution of Margarita Malakyan to the development of radiation biology in Armenia and how her multidisciplinary collaboration with chemists, physicists and biologists around the world led to the development of radioprotectors and radiosensitizers of different origins. CONCLUSION Margarita Malakyan was a very active and initiative woman, a radiobiologist, whose hard work and enthusiasm led to the establishment of a very constructive scientific network and to the develo...
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#1Gohar TsakanovaH-Index: 6
#2Elina ArakelovaH-Index: 5
Last. Bagrat GrigoryanH-Index: 7
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Recently, a new technology of low-energy ultrashort-pulsed electron beam (UPEB) accelerators has been developed opening new directions for radiobiology and biomedical research. The purpose of this study was to reveal the lethal dose, LD50 (lethal dose, 50%) delivered by low-energy UPEB whole-body exposure on an organismal level. Wistar rats were exposed to low-energy UPEB whole-body irradiation with different doses and pulse repetition rates to find the LD50 and in silico computer simulations we...
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For the last years, copper complexes have been intensively implicated in biomedical research as components of cancer treatment. Herewith, we provide highlights of the synthesis, physical measurements, structural characterization of the newly developed Cu(II) chelates of Schiff Bases, Cu(Picolinyl-L-Tryptopahanate)2, Cu(Picolinyl-L-Tyrosinate)2, Cu(Isonicotinyl-L-Tyrosinate)2, Cu(Picolinyl-L-Phenylalaninate)2, Cu(Nicotinyl-L-Phenylalaninate)2, Cu(Isonicotinyl-L-Phenylalaninate)2, and their radioe...
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Last. Arsen ArakelyanH-Index: 17
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Red blood cells (RBCs) are unceasingly exposed to exogenous reactive oxygen species (ROS) during their passage through the circulatory system. Nevertheless, RBCs have a large antioxidant system including ascorbate, vitamin E, catalase, superoxide dismutase, ergothioneine, glutathione, glutathione peroxidase and peroxiredoxin, which are assumed to eliminate ROS. The purpose of this study is to design a new effective method for evaluation of oxidative stress in human living RBCs using two-photon m...
#1Gohar TsakanovaH-Index: 6
#2Violetta AyvazyanH-Index: 4
Last. Arsen ArakelyanH-Index: 17
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Abstract Accounting for increasingly developed population aging and dramatic elevation of aging-related severe disorders worldwide, search of the efficient antiaging agents is becoming one of the urgent problems of contemporary biomedical science. The aim of current study was to reveal the potential protective effects of water-soluble proteins extracted from albumen gland of snails against aging processes. We evaluated the antioxidant effect of the extract in 20 older adult rats in vivo and on 6...
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#1Gohar Tsakanova (NAS: National Academy of Sciences)H-Index: 6
#2Elina Arakelova (NAS: National Academy of Sciences)H-Index: 5
Last. Arsen Arakelyan (NAS: National Academy of Sciences)H-Index: 17
view all 8 authors...
According to the “oxidative stress theory” of aging, this process is accompanied by a progressive and irreversible accumulation of oxidative damage caused by reactive oxygen species (ROS). This, in turn, has a deleterious impact on molecular mechanisms in aging thereby altering the physiological function of the organism, increasing the risk of different aging-related diseases, as well as impacting the life span. The aim of the current study was to investigate oxidative stress in living red blood...
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