X. Wang
Shanghai Jiao Tong University
PiezoelectricityCasimir effectQuantum dotFinite element methodComposite materialMitochondrial fissionChemistryMaterials scienceModulusThermalUmbilical veinNeovascularizationSonodynamic therapyPyrrolePyridineAngiogenesisAngiotensin IIGrapheneTube formationCarbon nanotubeDisplacement (vector)MechanicsClassical mechanicsCell biology
18Publications
8H-index
214Citations
Publications 18
Newest
#1Siwei Yang (CAS: Chinese Academy of Sciences)H-Index: 30
#2X. Wang (SJTU: Shanghai Jiao Tong University)H-Index: 8
Last. Guqiao Ding (CAS: Chinese Academy of Sciences)H-Index: 37
view all 8 authors...
Those responsible for the development of sonosensitizers are faced with a dilemma between high sonosensitization efficacy and good biosecurity that limited the development of sonodynamic therapy (SDT). Herein, inspired by the intriguing therapeutic features of SDT and the potential catalytic activity of graphene quantum dots, the potential of N-doped graphene quantum dots (N-GQDs) to act as a sonosensitizer is demonstrated. The superior sonosensitization effect of N-GQDs is believed to be three ...
12 CitationsSource
#1Siwei Yang (CAS: Chinese Academy of Sciences)H-Index: 30
#2X. Wang (SJTU: Shanghai Jiao Tong University)H-Index: 8
Last. Guqiao Ding (CAS: Chinese Academy of Sciences)H-Index: 37
view all 8 authors...
1 CitationsSource
#1Gao-Jian Huang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Han-Ping Yu (CAS: Chinese Academy of Sciences)H-Index: 4
Last. Jun-Li Duan (SJTU: Shanghai Jiao Tong University)H-Index: 9
view all 8 authors...
Hydroxyapatite (HAP) is promising for the clinical treatment of bone defects because of its excellent biocompatibility and osteo-conductivity. However, highly porous HAP scaffolds usually exhibit high brittleness and poor mechanical properties, thus organic constituents are usually added to form composite materials. In this work, a highly porous and elastic aerogel made from ultralong HAP nanowires with ultrahigh porosity (∼98.5%), excellent elasticity and suitable porous structure is prepared a...
Source
#1X. Wang (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Gao-Jian Huang (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Zhen Li (SJTU: Shanghai Jiao Tong University)H-Index: 12
view all 8 authors...
Background and aim: Modulating biological functions of endothelial progenitor cells (EPCs) is essential for therapeutic angiogenesis in ischemic vascular diseases. This study aimed to explore the role and molecular mechanisms of β-arrestin 2 (Arrb2) in EPCs biology and angiogenic therapy. Methods: The influence of Arrb2 on postischemic neovascularization was evaluated in Arrb2-deficient mice. The proliferation, apoptosis, and various functions of EPCs were analyzed in vitro by manipulating the e...
1 CitationsSource
#1Gao-Jian Huang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Zhilei Cong (Fudan University)H-Index: 1
Last. Jia Qi (SJTU: Shanghai Jiao Tong University)H-Index: 17
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AIMS: Adventitial remodeling presenting with the phenotypic switch of adventitial fibroblasts (AFs) to myofibroblasts (MFs) is reportedly involved in the evolution of several vascular diseases, including hypertension. In our previous study, we reported that heat shock protein 90 (HSP90) inhibition by 17-dime-thylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) markedly attenuates angiotensin II (AngII)-induced abdominal aortic aneurysm formation by simultaneously inhibiting several key signali...
11 CitationsSource
#1X. Wang (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Jia Qi (SJTU: Shanghai Jiao Tong University)H-Index: 17
Last. Jun-Li Duan (SJTU: Shanghai Jiao Tong University)H-Index: 9
view all 13 authors...
Statins and therapeutic ultrasound (TUS) have been shown to ameliorate angiogenesis on ischemic hindlimb animals and promote human umbilical vein endothelial cells (HUVECs) tube formation and proliferation. Here, we evaluate the therapeutic effect of TUS in combination with atorvastatin (Ator) therapy on angiogenesis in hindlimb ischemia and HUVECs. After subjecting excision of the left femoral artery, all mice were randomly distributed to one of four groups: Control; Ator treated mice (Ator); T...
7 Citations
#1Jia Qi (SJTU: Shanghai Jiao Tong University)H-Index: 17
#2Feng Wang (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Jun-Li Duan (SJTU: Shanghai Jiao Tong University)H-Index: 6
view all 9 authors...
Hypertension-induced cardiac apoptosis is a major contributor to early-stage heart-failure. Our previous studies have found that p53-mediated mitochondrial fission is involved in aldosterone-induced podocyte apoptosis. However, it is not clear that whether p53-induced mitochondrial fission is critical for hypertensive AngiotensinⅡ (AngⅡ)-induced cardiomyocyte apoptosis. In this study, we found that inhibition of the mitochondrial fission protein Drp1 (dynamin-related protein 1) by Mdivi-1 preven...
38 CitationsSource
#1Zhi-Xiao Su (ECUST: East China University of Science and Technology)H-Index: 1
#2Yi-Qin Shi (Fudan University)H-Index: 7
Last. Rui WangH-Index: 30
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Nanostructured calcium phosphate (CaP) and magnesium phosphate (MgP) are promising for the application as the nanocarriers in drug delivery. However, the difference between CaP and MgP nanocarriers in drug delivery is rarely investigated. In this work, we comparatively investigated nanostructured CaP, MgP and calcium magnesium phosphate (CMP) for the delivery of SRT1720, which is a silent information regulator (SIRT1) specific activator with pro-angiogenic and anti-aging properties in response t...
1 Citations
#1W.D. Yang (SJTU: Shanghai Jiao Tong University)H-Index: 9
#2Yipo Li (SJTU: Shanghai Jiao Tong University)H-Index: 7
Last. X. Wang (SJTU: Shanghai Jiao Tong University)H-Index: 8
view all 3 authors...
AbstractThis paper proposes a scale-dependent model to investigate the dynamic-pull-in characteristics of a functionally graded carbon nanotubes (FGCNTs) reinforced nanodevice with a piezoelectric layer. Based on nonlocal beam theory, the nonlinear thermoelectromechanical coupling dynamic governing equation of an electrostatically actuated nanodevice is derived. The material properties of the functionally graded layer depend on temperature environment, thickness, volume ratio, and distribution o...
3 CitationsSource
#1W.D. Yang (SJTU: Shanghai Jiao Tong University)H-Index: 9
#2Chen Fang (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. X. Wang (SJTU: Shanghai Jiao Tong University)H-Index: 8
view all 3 authors...
Abstract A size-dependent model of functionally graded carbon nanotubes (FGCNTs) reinforced microbeam with piezoelectric layer is presented based on unifying nonlocal stress and strain gradient framework. Nonlinear dynamic characteristics of the microbeam arise from electrostatic, piezoelectric actuation and thermal loading, with consideration of quantum and thermal fluctuations induced Casimir force. The nonlinearly dynamic frequency and pull-in instability of FGCNTs reinforced microbeam with d...
18 CitationsSource