Claudia Brizuela
University of Los Andes
Regenerative medicineCell therapyMorphology (linguistics)AdipogenesisH&E stainInternal medicineBiocompatible materialSurgeryCellular differentiationLogistic regressionMolecular biologyOdds ratioPulp cappingRandomized controlled trialRegeneration (biology)Pulp (tooth)Exact testMaterials scienceMesenchymal stem cellDentistryMolarIn vitroIn vivoForensic dentistryPermanent teethEndodontic therapyMineral trioxide aggregateDental pulp stem cellsPlatelet-rich fibrinAsymptomaticPost-mortem intervalMandibular second premolarOral and maxillofacial surgeryRegenerative endodonticsPulp necrosisCalcium hydroxidePulpitisDens invaginatusRoot canalCone beam computed tomographyEndodonticsMandibular first premolarPeriodontitisAngiogenesisPremolarElectric pulp testLesionStem cellMandibular molarPopulationDentinal FluidDirect pulp capping (procedure)Tissue scaffoldsDental Pulp CavityOrthodonticsMaterials testingRna degradationProliferation rateTooth pulp stimulationMean agePhase i iiChondrogenesisRigor mortisCancer researchClinical trialFibrinComputed tomographyFlow cytometryReceiver operating characteristicTrichromeMandibular first molarMedicineBiomarker (medicine)Area under the curveBiologyGastroenterologyLivor mortis
Publications 12
#1Carolina Inostroza (University of Los Andes)H-Index: 6
#2Ana María Vega-Letter (Universidad del Desarrollo)H-Index: 7
Last. Flavio Carrión (Universidad del Desarrollo)H-Index: 20
view all 7 authors...
INTRODUCTION Dental pulp stem cells (DPSC) are very attractive in regenerative medicine. In this study, we focused on the characterization of the functional properties of mesenchymal stem cells derived from DPSCs. Currently, it is unknown whether inflammatory conditions present in an inflamed dental pulp tissue could alter the immunomodulatory properties of DPSCs. This study aimed to evaluate the immunomodulatory capacity in vitro of DPSCs derived from healthy and inflamed dental pulp. METHODS D...
#1Claudia Brizuela (University of Los Andes)H-Index: 7
#2G. Meza (University of Los Andes)H-Index: 2
Last. Valeria Ramírez (University of Los Andes)H-Index: 8
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AIM To explore a set of inflammatory biomarkers obtained from dentinal fluid (DF) from patients with symptomatic irreversible pulpitis (IP), reversible pulpitis (RP) and normal pulp (NP). METHODOLOGY A cross-sectional exploratory study was performed, recruiting 64 patients on the basis of their respective pulp condition. DF samples were obtained from all patients (23, from IP patients; 20, from RP patients; and 21, from NP patients). Quantification of biomarkers was performed using a Luminex® MA...
5 CitationsSource
#1Claudia Brizuela (University of Los Andes)H-Index: 7
#2G. Meza (University of Los Andes)H-Index: 2
Last. Maroun Khoury (University of Los Andes)H-Index: 29
view all 10 authors...
A randomized controlled phase I/II clinical trial was designed to evaluate the safety and efficacy of encapsulated human umbilical cord mesenchymal stem cells in a plasma-derived biomaterial for regenerative endodontic procedures (REPs) in mature permanent teeth with apical lesions. The trial included 36 patients with mature incisors, canines, or mandibular premolars showing pulp necrosis and apical periodontitis. Patients were randomly and equally allocated between experimental (REP) or convent...
10 CitationsSource
#1Gastón Meza (University of Los Andes)H-Index: 1
#2Denisse Urrejola (University of Los Andes)H-Index: 1
Last. Claudia Brizuela (University of Los Andes)H-Index: 7
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Abstract Introduction Regenerative endodontic procedures have emerged as a new treatment. The aim of this case report was to describe a regenerative autologous cellular therapy using mesenchymal stem cells from inflamed dental pulp and leukocyte platelet-rich fibrin (L-PRF) in a mature tooth. Methods A healthy 50-year-old man consulting for spontaneous dental pain was referred for endodontic treatment in tooth #28, which was diagnosed with symptomatic irreversible pulpitis. Inflamed dental pulp ...
15 CitationsSource
#1Ioannis Angelopoulos (University of Los Andes)H-Index: 5
#2Claudia Brizuela (University of the Andes, Chile)H-Index: 7
Last. Maroun Khoury (University of Los Andes)H-Index: 29
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High donor variation makes comparison studies between different dental sources dubious. Dental tissues offer a rare opportunity for comparing the biological characteristics of haploidentical mesenchymal stem cells (MSCs) isolated from the same donor. The objective was to identify the optimal dental source of MSCs through a biological and functional comparison of haploidentical MSCs from gingival (GMSCs) and dental pulp stem cells (DPSCs) focusing mainly on their angiogenic potential. The compari...
14 CitationsSource
#1Eugenia Pedemonte (University of Los Andes)H-Index: 1
#2Carolina Cabrera (University of Los Andes)H-Index: 4
Last. Claudia Brizuela (University of Los Andes)H-Index: 7
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Objective To describe mandibular premolar root and canal morphology and its variability in Chilean and Belgian samples using cone-beam computed tomography.
11 CitationsSource
#1Claudia BrizuelaH-Index: 7
#2D. UrrejolaH-Index: 1
Last. Maroun KhouryH-Index: 29
view all 5 authors...
#1Claudia Brizuela (University of Los Andes)H-Index: 7
#2Andrea Ormeño (University of Los Andes)H-Index: 1
Last. Montse Mercadé (University of Barcelona)H-Index: 5
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Abstract Introduction Direct pulp capping treatment is intended to preserve pulp vitality, to avoid or retard root canal treatment, and, in cases with an open apex, to allow continued root development. Historically, calcium hydroxide (CH) was the gold standard material, but nowadays calcium silicate materials (CSMs) are displacing CH because of their high bioactivity, biocompatibility, sealing ability, and mechanical properties. However, more randomized clinical trials are needed to confirm the ...
55 CitationsSource
#1Nelson Pinto (Katholieke Universiteit Leuven)H-Index: 13
#2Alexandra Harnish (University of Los Andes)H-Index: 1
Last. Claudia Brizuela (University of Los Andes)H-Index: 7
view all 6 authors...
Abstract Regenerative endodontic procedures (REPs) associated with apical surgery could represent an alternative treatment strategy for patients whose teeth present incomplete root formation and extensive apical lesions. Leukocyte platelet-rich fibrin (L-PRF) has potential benefits in REPs; it could promote apical root formation and optimal bone healing. The aim of this case report was to describe innovative regenerative endodontic therapy using L-PRF in the root canal and an extensive apical le...
13 CitationsSource
#1Patricio Carrasco (University of Los Andes)H-Index: 2
#2Claudia Brizuela (University of Los Andes)H-Index: 7
Last. Carolina Inostroza (University of Los Andes)H-Index: 6
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Abstract Background The correct estimation of the post mortem interval (PMI) can be crucial on the success of a forensic investigation. Diverse methods have been used to estimate PMI, considering physical changes that occur after death, such as mortis algor, livor mortis, among others. Degradation after death of dental pulp is a complex process that has not yet been studied thoroughly. It has been described that pulp RNA degradation could be an indicator of PMI, however this study is limited to ...
6 CitationsSource