José T. Egaña
Pontifical Catholic University of Chile
Regenerative medicineBiomedical engineeringSurgeryPathologyRegeneration (biology)ChemistryMesenchymal stem cellIn vivoEx vivoOxidative stressChlamydomonas reinhardtiiWound healingAngiogenesisStem cellTissue engineeringMedicineBiologyScaffoldCell biologyPharmacology
61Publications
19H-index
1,263Citations
Publications 43
Newest
#1Myra N. Chávez (LMU: Ludwig Maximilian University of Munich)H-Index: 9
#2Benedikt Fuchs (LMU: Ludwig Maximilian University of Munich)
Last. Thilo L. Schenck (LMU: Ludwig Maximilian University of Munich)H-Index: 19
view all 10 authors...
Abstract Impaired wound healing represents an unsolved medical need with a high impact on patients´ quality of life and global health care. Even though its causes are diverse, ischemic-hypoxic conditions and exacerbated inflammation are shared pathological features responsible for obstructing tissue restoration. In line with this, it has been suggested that promoting a normoxic pro-regenerative environment and accelerating inflammation resolution, by reinstating the lymphatic fluid transport, co...
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#1Myra N. Chávez (LMU: Ludwig Maximilian University of Munich)H-Index: 9
#2Nicholas Moellhoff (LMU: Ludwig Maximilian University of Munich)H-Index: 5
Last. Jörg Nickelsen (LMU: Ludwig Maximilian University of Munich)H-Index: 34
view all 5 authors...
Without the sustained provision of adequate levels of oxygen by the cardiovascular system, the tissues of higher animals are incapable of maintaining normal metabolic activity, and hence cannot survive. The consequence of this evolutionarily suboptimal design is that humans are dependent on cardiovascular perfusion, and therefore highly susceptible to alterations in its normal function. However, hope may be at hand. "Photosynthetic strategies," based on the recognition that photosynthesis is the...
2 CitationsSource
#1Christ Devia (University of Chile)H-Index: 5
#2José T. Egaña (University of Chile)H-Index: 19
Last. Pedro Maldonado (University of Chile)H-Index: 22
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#1Michelle McLuckie (UZH: University of Zurich)H-Index: 2
#2Francesco Robotti (ETH Zurich)H-Index: 8
Last. Nicole Lindenblatt (UZH: University of Zurich)H-Index: 18
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Abstract After skin tissue injury or pathological removal, vascularization timing is paramount in graft survival. As full thickness skin grafts often fail to become perfused over larger surfaces, split-thickness grafts are preferred and can be used together with biomaterials, which themselves are non-angiogenic. One way of promoting vascular ingrowth is to “pre-vascularize” an engineered substitute by introducing endothelial cells (ECs). Since it has been previously demonstrated that surface str...
1 CitationsSource
#1Montserrat Jarquín-Cordero (LMU: Ludwig Maximilian University of Munich)H-Index: 2
#2Myra N. Chávez (LMU: Ludwig Maximilian University of Munich)H-Index: 9
Last. Jörg Nickelsen (LMU: Ludwig Maximilian University of Munich)H-Index: 34
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The recent use of photosynthetic organisms such as Chlamydomonas reinhardtii in biomedical applications has demonstrated their potential for the treatment of acute and chronic tissue hypoxia. Moreover, transgenic microalgae have been suggested as an alternative in situ drug delivery system. In this study, we set out to identify the best available combination of strains and expression vectors to establish a robust platform for the expression of human pro-angiogenic growth factors, i.e., hVEGF-165...
4 CitationsSource
#1Miguel Miranda (UDLAP: Universidad de las Américas Puebla)H-Index: 2
#2José T. Egaña (UC: Pontifical Catholic University of Chile)H-Index: 19
Last. Antonio Eblen-Zajjur (UC: Pontifical Catholic University of Chile)H-Index: 2
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Abstract The study of myocardial transmembrane ion currents is fundamental to understand frequent pathologies such as arrhythmias and ischemia. Conventional electrocardiography (ECG) is not able to...
2 CitationsSource
#1Geraldine Aedo (University of Chile)H-Index: 3
#2Miguel Miranda (UDLAP: Universidad de las Américas Puebla)H-Index: 2
Last. José T. Egaña (UC: Pontifical Catholic University of Chile)H-Index: 19
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: The World Health Organization has estimated that, worldwide, cigarette smoking has caused more than 100 million deaths in the last century, a number that is expected to increase in the future. Understanding cigarette smoke toxicity is key for research and development of proper public health policies. The current challenge is to establish a reliable preclinical model to evaluate the effects of cigarette smoke. In this work, we describe a simple method that allows for quantifying the toxic effec...
2 CitationsSource
#1Daniel Schmauss (TUM: Technische Universität München)H-Index: 11
#2Andrea Weinzierl (TUM: Technische Universität München)H-Index: 3
Last. Yves Harder (TUM: Technische Universität München)H-Index: 8
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Summary It has been shown that pre- and postconditioning of ischemically challenged tissue with erythropoietin (EPO) is able to reduce necrosis in a dose-dependent manner. The aim of this study was to determine the tissue-protective effects of different EPO dosages and administration regimes. Three groups of six C57Bl/6-mice each were analyzed: (1) pre- and postconditioning with initial high doses of EPO (starting at 2500 I.U./kg bw i.p.) followed by low doses of EPO (125 I.U./kg bw i.p.) (EPO-h...
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#1Marjorie Alvarez (University of Chile)H-Index: 3
#2Myra N. Chávez (University of Chile)H-Index: 9
Last. José T. Egaña (UC: Pontifical Catholic University of Chile)H-Index: 19
view all 6 authors...
Cigarette smoke is associated with several pathologies including chronic respiratory diseases and cancer. In addition, exposure to cigarette smoke is correlated with impaired wound healing, where a significant decrease in the regenerative capacity of smokers is well documented and broadly considered a negative risk factor after trauma or surgery. So far, some in vitro and in vivo models have been described to study how exposure to cigarette smoke diminishes the regenerative potential in differen...
1 CitationsSource
#1Carolina Centeno-Cerdas (TUM: Technische Universität München)H-Index: 3
#2Montserrat Jarquín-Cordero (LMU: Ludwig Maximilian University of Munich)H-Index: 2
Last. José T. Egaña (UC: Pontifical Catholic University of Chile)H-Index: 19
view all 9 authors...
Surgical sutures represent the gold standard for wound closure, however, their main purpose is still limited to a mechanical function rather than playing a bioactive role. Since oxygen and pro-regenerative growth factors have been broadly described as key players for the healing process, in this study we evaluated the feasibility of generating photosynthetic sutures that, in addition to mechanical fixation, could locally and stably release oxygen and recombinant human growth factors (VEGF, PDGF-...
16 CitationsSource