Reham S. Ibrahim
Alexandria University
Virtual screeningHigh performance thin layer chromatographyCancerDocking (molecular)Internal medicineChemometricsPattern recognition (psychology)Artificial intelligenceRandomized controlled trialPattern recognitionChemistryPhytochemicalFingerprintIn vitroPartial least squares regressionPrincipal component analysisIn silicoLuteolinAromataseDerivatizationMetaboliteAntioxidantMucositisMedicinal plantsPropolisIsolation (health care)Factor Xa InhibitorSpectral dataRelationship analysisChemotherapy inducedQuality assessmentFood scienceChromatographyBiochemistryPharmacophoreADMELinear discriminant analysisMedicineBiologyHierarchical clusteringPharmacology
25Publications
5H-index
62Citations
Publications 21
Newest
#1Hend M. Dawood (Alexandria University)H-Index: 1
#2Eman Shawky (Alexandria University)H-Index: 11
Last. Reham S. Ibrahim (Alexandria University)H-Index: 5
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Introduction null Aromatase is a CYP450 enzyme that catalyses the conversion of androgens into oestrogens, where the decrease in the production of oestrogens aided by aromatase inhibitors is considered a target in post-menopausal breast cancer therapy. TLC-bioautography is a technique employed for combining chromatographic separations on TLC plates with bioassays. This is the first report to evaluate aromatase inhibitory activity using this technique. null Objectives null The aim of this study i...
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#1Reham S. IbrahimH-Index: 5
Last. Alaa A. El-Banna (Alexandria University)H-Index: 1
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Cancer is one of the predominant causes of death worldwide. The new trend nowadays is to exploit natural products with the hope of developing new anticancer agents with fewer side effects. Propolis is one of these natural products which showed effectiveness in cancer treatment. The aim of this study is to understand the multi-level mechanism of action of propolis constituents in cancer treatment using an integrated approach of network pharmacology-based analysis, molecular docking and in vitro c...
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#1Dina S. Ghallab (Alexandria University)H-Index: 1
#2Mohamed M. Mohyeldin (Alexandria University)H-Index: 12
Last. Reham S. Ibrahim (Alexandria University)H-Index: 5
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Abstract In the current study, propolis samples from various geographical localities in Egypt were investigated by chemical profiling and xanthine oxidase (XO) inhibitory and radical scavenging activity testing. Metabolic fingerprints were attained using ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS), UHPLC-MS analysis in an untargeted holistic perspective followed by the subsequent annotation of 65 compounds in total. Variation in chemical profiles...
1 CitationsSource
#1Reham S. IbrahimH-Index: 5
#2Rahma Sr. MahrousH-Index: 2
Last. Hoda M. FathyH-Index: 4
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Selective factor Xa inhibitors effectively block coagulation cascade with a broader therapeutic window than multitargeted anticoagulants They have evolved as a crucial part of prevention and treatment of thromboembolic diseases and in therapeutic protocols involved in many clinical trials in coronavirus disease 2019 (COVID-19) patients Biologically-guided isolation of specific FXa inhibitors from licorice (Glycyrrhiza glabra) root extract furnished ten flavonoids By detailed analysis of their ¹H...
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#1Mahmoud Ahmed Elhadad (Alexandria University)
#2Ehsan El‐Negoumy (Alexandria University)
Last. Rasha O. Elsaka (Alexandria University)H-Index: 2
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Objective To clinically assess the effectiveness of topical chamomile oral gel in the prevention of chemotherapy-induced oral mucositis. Material and methods A parallel single-blind randomized clinical trial conducted on 45 patients who were undergoing chemotherapy. Patients were assigned to three equal groups. Group I received conventional symptomatic treatment that included antifungal agents (Miconaz oral gel, Medical Union Pharmaceuticals), topical anesthetics, and anti-inflammatory agent (BB...
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Abstract. Aromatase inhibitors are important in certain cancers such as breast cancer in postmenopausal women. In this study, eight constituents from Artemisia annua L. and Vitex agnus-castus L. were isolated and evaluated for their aromatase inhibitory activity using in-vitro fluorimetric assay. All tested compounds possessed moderate to strong inhibitory activity with β-sitosterol and myricetin-3,7,4'-trimethyl ether being the most active with IC50 values of 0.13 and 0.25 μM, respectively. Com...
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Last. Rasha O. ElsakaH-Index: 2
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1 CitationsSource
#1Eman Shawky (Alexandria University)H-Index: 11
#2Ahmed A. Nada (Alexandria University)H-Index: 1
Last. Reham S. Ibrahim (Alexandria University)H-Index: 5
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Since the outbreak of Coronavirus disease (COVID-19) caused by SARS-CoV-2 in December 2019, there has been no vaccine or specific antiviral medication for treatment of the infection where supportive care and prevention of complications is the current management strategy. In this work, the potential use of medicinal plants and more than 16 500 of their constituents was investigated within two suggested therapeutic strategies in the fight against SARS-CoV-2 including prevention of SARS-CoV-2 RNA s...
10 CitationsSource