Xiaobo Wang
Dalian Medical University
BioassayCytotoxicityEnzymeChemistryApoptosisIn vitroIn vivoMetaboliteMelatoninHydroxylationBiotransformationCancer researchBiochemistryCell growthMetabolismSignal transductionStereochemistryMedicineProtein kinase BHuskBiologyPharmacology
14Publications
9H-index
154Citations
Publications 14
Newest
#1G Sun (Dalian Medical University)H-Index: 1
#2Xiaobo Wang (Dalian Medical University)H-Index: 9
Last. J Sun (Dalian Medical University)H-Index: 1
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As a potent neurotoxic agent, acrylamide (ACR) is formed in food processing at higher temperature. Taurine (TAU), a nonessential amino acid, is used to cure neurodegenerative disorders, followed by...
7 CitationsSource
#1Ruiya Zhang (Dalian Medical University)H-Index: 1
#2Yonglei Cui (Dalian Medical University)H-Index: 7
Last. Zhonghui Yu (Dalian Medical University)H-Index: 1
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Background Baicalein is the major bioactive flavonoid in some herb medicines and dietary plants; however, the detailed metabolism pathway of its major metabolite oroxylin A-7-O-β-d-glucuronide in human was not clear. It was important to illustrate the major metabolic enzymes that participate in its elimination for the clinic use of baicalein.
10 CitationsSource
#1Da Wang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Dan Su (SPU: Shenyang Pharmaceutical University)H-Index: 7
Last. Xiaobo WangH-Index: 9
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Abstract The high edible oil content of Xanthoceras sorbifolia Bunge seeds contributes to its economic value. In this study, we analysed the barrigenol-like triterpenoids derived from X. sorbifolia husks. We also identified anti-tumour agents that could enhance the health benefits and medicinal value of X. sorbifolia. We isolated 10 barrigenol triterpenoids, including six new compounds (1–6) and four known compounds (7–10). New compounds 3 and 5 showed significant inhibitory activity against the...
12 CitationsSource
#1Weiru Jiang (Dalian Medical University)H-Index: 2
#2Xiangge Tian (Dalian Medical University)H-Index: 18
Last. Xiaochi Ma (Dalian Medical University)H-Index: 26
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Abstract Melatonin (Mel) as an endogenous hormone, has been widely used in clinic for multiple therapeutic purposes. Further, the natural anthraquinones were widespread in various plants including herbs, foods, and some flavoring agents. The present work aims to evaluate the metabolic disorder of Mel caused by various common herbs and further identify their underlying mechanism. More importantly, the relationships between inhibitory activity and their structures were also investigated. Our resul...
10 CitationsSource
#1Chao Wang (Dalian Medical University)H-Index: 21
#2Xiaokui Huo (Dalian Medical University)H-Index: 22
Last. Xiaochi Ma (Dalian Medical University)H-Index: 26
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Background and Purpose Herbs which are widely used as food and medicine, are involved in many physiopathological processes. Melatonin is a human hormone, synthesized and secreted by the pineal gland, with a range of biological functions. Here, we have evaluated the potential influences of components extracted from common herbs on melatonin metabolism in humans. Experimental Approach An in vivo pharmacokinetic study involving 12 healthy subjects, in vitro incubations with human liver microsomes (...
10 CitationsSource
#1Liyuan Zhang (Dalian Medical University)H-Index: 6
#2Zhenlong Yu (Dalian Medical University)H-Index: 18
Last. Xiaochi MaH-Index: 26
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// Liyuan Zhang 1, * , Zhenlong Yu 1, 2, * , Yan Wang 1, 2 , Xiaobo Wang 2 , Lianru Zhang 3 , Chao Wang 1 , Qingxi Yue 1, 4 , Xun Wang 5 , Sa Deng 1 , Xiaokui Huo 1 , Xiangge Tian 1 , Shanshan Huang 1 , Baojing Zhang 1 , Xiaochi Ma 1 1 Dalian Medical University, Dalian, China 2 Department of Pharmacy and Traditional Chinese Medicine, Chinese People's Liberation Army 210 Hospital, Dalian, China 3 State Key Lab of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China 4...
12 CitationsSource
#1Da Wang (SPU: Shenyang Pharmaceutical University)H-Index: 4
#2Dan Su (SPU: Shenyang Pharmaceutical University)H-Index: 7
Last. Xiaobo WangH-Index: 9
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Barrigenol-like triterpenoids containing angeloyl residues in their structures are unusual natural products. To discover the chemical constituents responsible for the antitumor activity of Xanthoceras sorbifolia Bunge, the present study was carried out using the husk of this crop. Ten angeloyl barrigenol triterpenoids, including seven new (1–7) and three known compounds (8–10), were isolated from the active fraction via the bioassay-guided method. The structures of the compounds were established...
16 CitationsSource
#1Zhenlong YuH-Index: 18
#2Tao Li (ZJNU: Zhejiang Normal University)H-Index: 104
Last. Xiaochi MaH-Index: 26
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// Zhenlong Yu 1, * , Tao Li 2, * , Chao Wang 1 , Sa Deng 1 , Baojing Zhang 1 , Xiaokui Huo 1 , Bo Zhang 3 , Xiaobo Wang 1 , Yuping Zhong 4 , Xiaochi Ma 1 1 College of Pharmacy, Academy of Integrative Medicine, Dalian Medical University, Dalian, China 2 Department of Biology, College of Chemistry and Life Sciences, Zhejiang Normal University, Zhejiang, China 3 Department of Neurosurgery, The Second Affiliated Hospital of Dalian Medical University, Dalian, China 4 Department of Hematology, Beijin...
13 CitationsSource
#1Ning Tang (Dalian Medical University)H-Index: 3
#2Lei Shi (Dalian Medical University)H-Index: 3
Last. Xiaochi MaH-Index: 26
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// Ning Tang 1, * , Lei Shi 2, * , Zhenlong Yu 1, 4, * , Peipei Dong 1 , Chao Wang 1 , Xiaokui Huo 1 , Baojing Zhang 1 , Shanshan Huang 1 , Sa Deng 1 , Kexin Liu 1 , Tonghui Ma 3 , Xiaobo Wang 4 , Lijun Wu 4 , Xiao-Chi Ma 1, 4 1 College of Pharmacy, Academy of Integrative Medicine, Key Laboratory of Pharmacokinetic and Drug Transport of Liaoning, Dalian Medical University, Dalian, China 2 Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China 3 College of Basic Medical Science, ...
25 CitationsSource
#1Xiangge Tian (Dalian Medical University)H-Index: 18
#2Xiaokui Huo (Dalian Medical University)H-Index: 22
Last. Xiaochi Ma (Dalian Medical University)H-Index: 26
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Abstract Exogenous melatonin (Mel) is widely used in clinic for multiple therapeutic purposes. In metabolism pathways of Mel, 6-hydroxymelatonin-sulfate (S-O-Mel) and N-acetylserotonin sulfate (S-NAS) are the most abundant metabolites account for over 90% of total Mel metabolites in humans, indicating that sulfation plays an important role in reflecting the functions and clearance of Mel in vivo. In the present study, we characterized Mel sulfation using various human organ cytosols (liver, lung...
23 CitationsSource